Induction of NK1.1+ αβTCR+ T cells by bypassing TCR signals in ZAP-70 deficient mice

Generation of cytokine‐induced killer cells from leukaemic samples with in vitro cytotoxicity against autologous and allogeneic leukaemic blasts

“…Hence, the term NK‐like T cell was recently introduced to describe the CIK cell population (Lefterova et al , 2000; Zoll et al , 2000; Baker et al , 2001). An NK1·1 + CD3 + effector cell population derived from the exposure of T cells to IL‐2 stimulation has also been characterized in mice (Ikarashi et al , 1998; Assarsson et al , 2000; Tones et al , 2000). However, the mechanism of cytotoxicity mediated by this particular cell population, as to whether they follow either the T‐cell or NK‐cell pattern of target recognition, was not elaborated (Ikarashi et al , 1998; Assarsson et al , 2000; Tones et al , 2000).…”

“…An NK1·1 + CD3 + effector cell population derived from the exposure of T cells to IL‐2 stimulation has also been characterized in mice (Ikarashi et al , 1998; Assarsson et al , 2000; Tones et al , 2000). However, the mechanism of cytotoxicity mediated by this particular cell population, as to whether they follow either the T‐cell or NK‐cell pattern of target recognition, was not elaborated (Ikarashi et al , 1998; Assarsson et al , 2000; Tones et al , 2000). In the present study, we observed that the CIK effector cells killed allogeneic leukaemic targets with an efficacy similar to that of autologous targets (Fig 4).…”