Induction of ovulation by endothelin-3 in rats

Furudate, Sen-ichi; Masaki, Yohji; Muto, T

doi:10.1677/joe.0.1410109

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…in rats, whereas in another study, i.v. application of ET-3 in rats induced a more prominent release of LH in comparison to FSH and, moreover, initiated ovulation (Furudate et al, 1994). Furthermore, in the latter study a biphasic PRL response similar to in vitro findings was observed.…”

Section: Experiments In Animalssupporting

confidence: 82%

The role of endothelins in the regulation of pituitary function

Lange¹,

Pagotto²,

Renner³

et al. 2002

Exp Clin Endocrinol Diabetes

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The different members of the endothelin peptide family exhibit potent, long-lasting vasoconstrictive effects and thus play a central role in blood pressure regulation. However, endothelins have also been shown to modulate renal, cardiac and immune functions under physiological and pathophysiological conditions. In addition, endothelins are thought to be involved in the progression of some types of tumours. Soon after their discovery in 1988, it was shown that endothelins affect hormone release in the pituitary. Moreover, the intrapituitary production and expression of both endothelins and endothelin receptors have been described. This review summarises the present day knowledge concerning the expression and regulation of intrapituitary endothelins and their receptors. In addition, the effects of endothelins on hormone production by anterior, intermediate and posterior pituitary cell types are reviewed and their importance for pituitary physiology and pathophysiology is discussed.

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Section: Experiments In Animalssupporting

confidence: 82%

The role of endothelins in the regulation of pituitary function

Lange¹,

Pagotto²,

Renner³

et al. 2002

Exp Clin Endocrinol Diabetes

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“…There are several lines of evidence that point to endothelins participating in the regulation of pituitary hormone secretion (Vierhapper et al ., 1993; Vierhapper, 1996; Kiefer et al ., 2000). Release of LH and FSH is stimulated by ET‐3 (Kanyicska et al ., 1991; Furudate et al ., 1994; Naruse et al ., 1994). It was recently demonstrated that human neurons secreting GnRH produce and respond to ET‐1 and that this peptide positively regulates GnRH secretion (Maggi et al ., 2000).…”

Section: Discussionmentioning

confidence: 99%

Increased plasma endothelin levels in patients with male hypogonadism

et al. 2002

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Endothelin has various paracrine and endocrine effects on the male reproductive system. Testosterone is probably responsible for the higher endothelin levels in males. In addition, there is much ambiguity about the relationship between gonadotrophic hormones and endothelin. In order to study in more detail the relationship of endothelin with the hypothalamo-pituitary-gonadal axis in the male, we investigated 18 male patients with various forms of hypogonadism (seven with hypergonadotrophic hypogonadism and 11 with hypogonadotrophic hypogonadism). Eight age-matched healthy males served as controls. The basal endothelin levels in patients with hypogonadism (0.95 +/- 0.53 fmol ml(-1)) were significantly higher than those of the controls (0.54 +/- 0.06 fmol ml(-1); P < 0.05). Males with hypergonadotrophic hypogonadism had significantly increased endothelin concentrations (1.05 +/- 0.57 fmol ml(-1); P < 0.05), whereas those with hypogonadotrophic hypogonadism (0.89 +/- 0.53 fmol ml(-1)) had nonsignificantly (P > 0.05) elevated levels. No significant correlation was found between plasma endothelin levels and gonadotrophin, prolactin and testosterone concentrations. The results of this study suggest that plasma endothelin levels are increased in males with hypogonadism.

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“…Concentrations of TSH were measured by radioimmunoassay (RIA), previously reported method (Furudate et al, 1994), using reagents provided by the Rat Pituitary Hormone Program, NIDDK, NIH. The second antibody was anti‐rabbit IgG goat serum (donated by Dr. K. Wakabayashi).…”

Section: Methodsmentioning

confidence: 99%

Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland ofrdw rats with hereditary dwarfism

2000

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Previous studies on the rdw rat have suggested that its dwarfism is caused primarily by dysfunction of the thyroid gland. In this study, rat thyroid glands were analyzed endocrinologically and morphologically to clarify the primary cause of dwarfism in the rdw rat. The rdw rat showed lowered thyroid hormone (T4 and T3) levels but elevated TSH in serum. The rdw thyroid gland was almost proportional in size and it was not goiter in gross inspection. Our histological investigation produced three results that may lend important evidence in understanding the problem in the thyroid gland of rdw rats. First of all, secretory granules could not be detected in the follicular epithelial cells of the rdw. Secondly, thyroglobulin was found at very low levels in the follicular lumen by immunohistochemical analysis. In contrast, it could be detected in a substantial quantity inside the dilated rER and in the huge vacuoles that are formed by swelling of the rough endoplasmic reticulum (rER) at the basal side of the follicular epithelial cells. Additionally, the nucleus of the follicular epithelial cells was pressed to the luminal side by the enlarged rER. These morphological changes would indicate that the transport of thyroglobulin is stopped at or before the formation of the secretory granules and thyroglobulin is not secreted into the follicular lumen. The rdw characterization strongly supports that rdw dwarfism is induced by hypothyroidism due to some defect(s) in the thyroid gland.

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Induction of ovulation by endothelin-3 in rats

Cited by 7 publications

References 14 publications

The role of endothelins in the regulation of pituitary function

The role of endothelins in the regulation of pituitary function

Increased plasma endothelin levels in patients with male hypogonadism

Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland ofrdw rats with hereditary dwarfism

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