Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland ofrdw rats with hereditary dwarfism

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the endocrine organs (pituitary gland, pineal gland, thyroid gland, parathyroid glands, adrenal glands and pancreatic islets) of laboratory rats and mice, with color photomicrographs illustrating examples of the lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for endocrine lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

show abstract

“…( Abe et al 2012 ; Doi et al 2004 ; Kokoshima et al 2014 ; Sakai et al 2000 ; Shimoi et al 2001 ; Takaoka et al 1994 ; Weber et al 2009 )…”

Section: Thyroid Glandunclassified

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Brändli-Baiocco

Balme

Bruder³

et al. 2018

J Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…The vacuolar degeneration in the present case is very similar to the findings in reported rat cases in which the vacuoles reacted negatively to PAS and thyroglobulin 55 , 58 . Dilatation of RER in follicular cells has also been reported in animals with genetic hypothyroidism 56 , 57 , 59 , 60 , 61 , 62 , 63 . Dilatation of the RER might be the process through which thyroid hormone synthesis or secretion was affected.…”

Section: Vacuolar Degeneration Of Thyroid Follicular Cells In a Cynommentioning

confidence: 73%

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium

et al. 2013

View full text Add to dashboard Cite

The first joint Japanese Society of Toxicologic Pathology (JSTP) and National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held on January 29th at Okura Frontier Hotel in Tsukuba, Ibaraki, Japan, in advance of the JSTP’s 29th Annual Meeting. The goal of this Symposium was to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers’ presentations, including diagnostic or nomenclature issues that were presented, select images that were used for audience voting or discussion, and the voting results. Some lesions and topics covered during the symposium include: treatment-related atypical hepatocellular foci of cellular alteration in B6C3F1 mice; purulent ventriculoencephalitis in a young BALB/c mouse; a subcutaneous malignant schwannoma in a RccHan:WIST rat; spontaneous nasal septum hyalinosis/eosinophilic substance in B6C3F1 mice; a rare pancreatic ductal cell adenoma in a young Lewis rat; eosinophilic crystalline pneumonia in a transgenic mouse model; hyaline glomerulopathy in two female ddY mice; treatment-related intrahepatic erythrocytes in B6C3F1 mice; treatment-related subendothelial hepatocytes in B6C3F1 mice; spontaneous thyroid follicular cell vacuolar degeneration in a cynomolgus monkey; congenital hepatic fibrosis in a 1-year-old cat; a spontaneous adenocarcinoma of the middle ear in a young Crl:CD(SD) rat; and finally a series of cases illustrating some differences between cholangiofibrosis and cholangiocarcinoma in Sprague Dawley and F344 rats.

show abstract

“…The materials of intracellular vacuoles react positively for thyroglobulin in the dwarfs of GALAS rats 3,4 . The cause of vacuolation was thought to be a mutation of the thyroglobulin gene resulting in retention of misfolded thyroglobulin in r-ERs similar to the mechanism described for the rdw rat, which developed dwarfism by genetic hypothyroidism, and huge vacuoles in the thyroid gland 11 . In contrast, the vacuoles of GALAS rats showing normal growth with thyroid dysplasia were not stained for thyroglobulin in the present study and other reported works 2,4 .…”

Section: Discussionmentioning

confidence: 94%

Carcinogen-induced Thyroid Proliferative Lesions in Wistar Hannover GALAS Rats with Thyroid Dysplasia

et al. 2012

View full text Add to dashboard Cite

Incidences and morphological features of thyroid proliferative lesions induced by carcinogens in Wistar Hannover GALAS rats (GALAS rats) showing normal growth with or without thyroid dysplasia were examined. All thyroid tissue samples were obtained from our recently conducted study using male GALAS rats treated with 5 carcinogens according to the medium-term multiorgan carcinogenicity bioassay protocol (called DMBDD treatment). In the DMBDD-treated rats, thyroid dysplasia was found in 9 out of 114 rats. Follicular cell adenomas were found in 5 out of 9 rats with thyroid dysplasia and in 7 out of 105 rats without thyroid dysplasia. The incidence of adenoma was significantly increased in rats with thyroid dysplasia (55.6%) compared with that in rats without thyroid dysplasia (6.7%). Adenomas in rats with thyroid dysplasia were observed as single or multiple nodules, well demarcated and composed of variously sized vacuolated cells or unvacuolated cells. These histopathological features and staining profiles of luminal colloid for PAS and thyroglobulin, together with PCNA-positive cells, were fundamentally similar to those of rats without thyroid dysplasia. On the other hand, the luminal colloid in adenomas of rats with thyroid dysplasia had a tendency to be poorly stained for T4 compared with that of rats without thyroid dysplasia. From these findings, it appears that dysplastic thyroids of rats showing normal growth are more sensitive to carcinogens than normal thyroids. In addition, the morphological features of carcinogen-induced thyroid proliferative lesions in GALAS rats with thyroid dysplasia were fundamentally similar to those of rats without thyroid dysplasia, except for the vacuoles and T4 staining profile.

show abstract

Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland ofrdw rats with hereditary dwarfism

Cited by 28 publications

References 23 publications

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium

Carcinogen-induced Thyroid Proliferative Lesions in Wistar Hannover GALAS Rats with Thyroid Dysplasia

Contact Info

Product

Resources

About