Induction of p53ras specific cellular immunity in patients with common solid tumors

Gabrilovich, Dmitry I.; Kavanaugh, Denise; Ishida, Tadao; Ovama, Isunehiro; Lee, Choon Jaek; Nadaf, Sorena; Sepetavec, Tanya; Jensen, Roy A.; Gazdar, Adi; Ciernik, I. Frank; Corak, Jadranko; Berzofsky, Jay A.; Carbone, David P.

doi:10.1016/s0169-5002(97)83913-x

Cited by 8 publications

(9 citation statements)

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“…DC infiltrated into tumor tissue showed a reduced expression of co-stimulatory molecules, defective cytokine production, and full allostimulatory activity, implying that tumor-derived factors impede DC maturation. 28,29) These effects appear to be maturation-dependent, acting only on DC precursors and not mature DC. Therefore, it may be better to use mature DC for clinical use.…”

Section: Discussionmentioning

confidence: 99%

Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro

Kim¹,

Ko²,

Lee

et al. 2006

Biological & Pharmaceutical Bulletin

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Water extract (WE) of Cordyceps militaris has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not been known. In this study, we investigated whether water extract of C. militaris induces the phenotypic and functional maturation of dendritic cells (DC). It profoundly increased CD40, CD54, CD80, CD86, and MHC class II expression in murine bone marrow (BM)-derived myeloid DC. Endocytosis was assessed by the uptake of FITC-dextran and FITC-albumin. The ability of unstimulated DC (UT-DC) to uptake dextran and albumin was higher than that of WE-or LPS-stimulated DC (LPS-DC). Also, UT-DC secreted a low concentration of IL-12, while WE-or LPS-DC secreted higher levels of IL-12 than UT-DC. WE not only formed morphologically mature DC and clusters, but also induced predominantly functional maturation. Moreover, WE is shown to promote the cytotoxicity of specific-cytotoxic T lymphocyte (CTL) induced by DC which were pulsed with P815 tumor-lysate during the stage of antigen presentation. These results suggest that DC maturation by WE can play a critical role in the improvement of the immunoregulatory function in patients with impaired host defense.

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Section: Discussionmentioning

confidence: 99%

Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro

Kim¹,

Ko²,

Lee

et al. 2006

Biological & Pharmaceutical Bulletin

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“…[1][2][3][4] DC activate both naive and memory CD4 ϩ and CD8 ϩ T cells [35][36][37] and seem to meet all requirements as a strong immune-activator for anti-tumor immunity or immunity against microbial infection. [38][39][40] Located in most host tissues, DC function as immune sentinels for infectious agents and inflammatory products of bacteria. Immature DC can capture antigens in peripheral tissues and undergo maturation processes to stimulate naive T cells in secondary lymphoid organs.…”

Section: Pl Is Involved With Erk P38 Kinases and Nf-k Kb P65mentioning

confidence: 99%

Proteoglycan Isolated from Phellinus linteus Induces Toll-Like Receptors 2- and 4-Mediated Maturation of Murine Dendritic Cells via Activation of ERK, p38, and NF-.KAPPA.B

Kim

Han

Song

et al. 2004

Biological & Pharmaceutical Bulletin

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“…Tumours have the capacity to limit APC maturation, function and infiltration of the tumour site [27–30]. Thus the molecules that attract host APCs and T‐ cells could serve as potent agents for cancer immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Antitumour activity of cationic‐liposome‐conjugated adenovirus containing the CCL19 [chemokine (C‐C motif) ligand 19] gene

Cao

Deng

Zhao

et al. 2007

Biotech and App Biochem

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CCL19 [chemokine (C-C motif) ligand 19; also known as MIP-3beta (macrophage inflammatory protein-3beta) or ELC (Epstein-Barr-virus-induced molecule 1 ligand chemokine)], one of the immunostimulatory cytokines, chemoattracts both DCs (dendritic cells) and T-lymphocytes. Adenoviral vector is one of the most used gene delivery vectors for cancer therapy because of its high gene-transfection efficiency. However, its wider application is limited, owing to immune responses that reduce transgene expression and decrease the efficacy of repeated administration. We constructed the recombinant replication deficient adenoviral vectors containing the CCL19 gene (Ad-CCL19) and combined them with PEG-PE [poly(ethylene glycol)-phosphatidylethanolamine]-modified cationic liposomes (Ad-CCL19/PEG-PE) for immunotherapy against murine fibrosarcoma. Although there were hardly any therapeutic differences between Ad-CCL19- and Ad-CCL19/PEG-PE-treated mice that were observed at the second administration, the final results demonstrated that Ad-CCL19/PEG-PE-treated mice survived much longer. The antitumour efficacy may be related to the high level of CCL19 after the final administration and lasting expression of IFN-gamma (interferon-gamma) and IL-12 (interleukin-12) in the Ad-CCL19/PEG-PE-treated group, which were measured by reverse-transcription PCR and ELISA. The results demonstrated that PEG-PE-cationic-liposome-conjugated adenovirus could prolong the expression of the therapeutic gene in vivo and may enhance the antitumour efficacy.

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Induction of p53ras specific cellular immunity in patients with common solid tumors

Cited by 8 publications

References 0 publications

Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro

Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro

Proteoglycan Isolated from Phellinus linteus Induces Toll-Like Receptors 2- and 4-Mediated Maturation of Murine Dendritic Cells via Activation of ERK, p38, and NF-.KAPPA.B

Antitumour activity of cationic‐liposome‐conjugated adenovirus containing the CCL19 [chemokine (C‐C motif) ligand 19] gene

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