Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response

Distribution of Group II Phospholipase A2 Protein and mRNA in Rat Tissues

“…In humans, PLA2 has been also found in the Paneth cells of the small intestine and in a wide range of other tissues (Kiyohara et al 1992;Nevalainen and Haapanen 1993;Kallajoki and Nevalainen 1997). PLA2 is an acute-phase protein (Crowl et al 1991). Increased concentrations of PLA2 have been found in serum in various inflammatory diseases, including sepsis, infections, and acute pancreatitis (Nevalainen and Grönroos 1997).…”

Inhibitory Effect of Zingerone on Secretory Group IIA Phospholipase A2

“…sPLA2-IIA appears to play a role in the initiation and propagation of the vascular inflammation observed in sepsis, septic shock, and polytrauma [8-9, 17, 32-35]. In support of this, high levels of this molecule were detected in the sera of patients with inflammatory disorders [8,17,[33][34][35]. However, the possibility that sPLA2-IIA is only an inflammatory marker rather than a contributor to inflammation, has not been ruled out because administration of a selective sPLA2-IIA inhibitor to patients with sepsis or rheumatoid arthritis reversed the abnormal production of sPLA2-IIA but failed to improve the clinical outcome [36][37].…”

Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2

“…The sPLA2-IIA seems to play a role in the initiation and propagation of vascular inflammation such as severe sepsis, septic shock and polytrauma [8][9][22][23][24][25][26]. Supporting this, a high level of this molecule has been found in the sera of patients with inflammatory disorders [8,[23][24][25][26]. However, the possibility that sPLA2-IIA is only an inflammatory marker rather than a contributor to inflammation, has not been ruled out because selective sPLA2-IIA inhibitors were treated to septic patients or rheumatoid arthritis to oppose the abnormal production of sPLA2-IIA but failed to improve the clinical outcome [27][28].…”