Infant Calming Responses during Maternal Carrying in Humans and Mice

Esposito, Gianluca; Yoshida, Shigeo; Ohnishi, Ryuko; Tsuneoka, Yousuke; Rostagno, Maria del Carmen; Yokota, Susumu; Okabe, Shota; Kamiya, Kanichi; Hoshino, Mikio; Shimizu, Masaki; Venuti, Paola; Kikusui, Takefumi; Kato, Takeshi; Kuroda, Kumi O.

doi:10.1016/j.cub.2013.03.041

Cited by 125 publications

(164 citation statements)

References 24 publications

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“…Ultrasonic vocalizations (USVs) produced by mouse pups when they are isolated from their mother have been suggested to be a means by which the pups seek parental care. Notably, this form of communication is disrupted in various mouse models of autism (26)(27)(28). To determine if there is a defect in USV production in AS mice we recorded and quantified USVs emitted by wild-type and AS littermates when isolated from their homecage for 4 min.…”

Section: As Mice Display An Altered Developmental Time Course Of Ultrmentioning

confidence: 99%

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression

Mandel‐Brehm

Salogiannis

Dhamne

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Angelman syndrome (AS) is a neurodevelopmental disorder arising from loss-of-function mutations in the maternally inherited copy of the UBE3A gene, and is characterized by an absence of speech, excessive laughter, cognitive delay, motor deficits, and seizures. Despite the fact that the symptoms of AS occur in early childhood, behavioral characterization of AS mouse models has focused primarily on adult phenotypes. In this report we describe juvenile behaviors in AS mice that are strain-independent and clinically relevant. We find that young AS mice, compared with their wild-type littermates, produce an increased number of ultrasonic vocalizations. In addition, young AS mice have defects in motor coordination, as well as abnormal brain activity that results in an enhanced seizure-like response to an audiogenic challenge. The enhanced seizure-like activity, but not the increased ultrasonic vocalizations or motor deficits, is rescued in juvenile AS mice by genetically reducing the expression level of the activity-regulated cytoskeleton-associated protein, Arc. These findings suggest that therapeutic interventions that reduce the level of Arc expression have the potential to reverse the seizures associated with AS. In addition, the identification of aberrant behaviors in young AS mice may provide clues regarding the neural circuit defects that occur in AS and ultimately allow new approaches for treating this disorder.Angelman syndrome | ARC | EPHEXIN5 | ultrasonic vocalizations | EEG

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Section: As Mice Display An Altered Developmental Time Course Of Ultrmentioning

confidence: 99%

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression

Mandel‐Brehm

Salogiannis

Dhamne

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…Esposito ve ark. (58) tarafınan yapılan çalışmada ise, hareket halindeki annenin bebeğinin daha çabuk sakinleştiği, ağlaması-nın kesildiği ve kalp atımlarının da yavaşladığı saptanmıştır. Ayrıca uyku ve beslenme saatlerinin rutine konması ağlama sürelerinin %42 oranında azalttığı bildirilmektedir (59) .…”

Section: Davranışsal Tedaviunclassified

New looking to the old problem: Infantile Colic

Karabayır¹,

Gökçay²

2017

Cocuk Dergisi

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“…Instead, the mother mouse uses her mouth to grasp a bit of skin at the back of the mouse pup's neck (Figure 2). Researchers were able to recreate this grip by pinching this same spot [3][4][5][6]. This way, the researchers had more control over the experiment.…”

Section: How Does the Tr Work?mentioning

confidence: 99%

“…For example, a child who is developing normally relaxes into his mother's embrace when she carries him. But some parents report feeling "as if (they) were holding a stone or a sack of flour, not a baby, " when their child is crying [5]. These were the parents of children who were not physically adjusted to fit parental carrying.…”

Section: Parasympathetic Nervous System (Pns)mentioning

confidence: 99%

How Can I Make My Younger Sibling Stop Crying?

Truzzi¹,

Esposito²,

Coppola³

2016

Front. Young Minds.

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When a baby will not stop crying, it can be frustrating. One well-known trick parents use is holding the child and walking around for a while. We are just now finding out why this trick works. It has to do with what happens in two different parts of the brain: the parasympathetic nervous system (PNS) and the cerebellum. The PNS is the brain's relaxation command center. When babies are carried, the PNS relaxes their bodies (by dropping the heart rate), which gradually calms them down and stops their crying. Also, carrying triggers the cerebellum, which controls movement and makes the babies physically adjust, for example, by bending their legs to the person carrying them. Understanding how the brain works will teach us how to better soothe babies. In turn, the people taking care of the babies will be more relaxed, which will improve health, happiness, and parent-child relationships.

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Infant Calming Responses during Maternal Carrying in Humans and Mice

Cited by 125 publications

References 24 publications

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression

New looking to the old problem: Infantile Colic

How Can I Make My Younger Sibling Stop Crying?

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