Infant Mortality Statistics from the 1999 Period: Linked Birth/Infant Death Data Set

Matthews, Thomas R.; MacDorman, Marian F.

doi:10.1037/e558952006-001

Cited by 1,276 publications

(1,791 citation statements)

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“…Specifically, rates are highest among African American infants and more than 2 times greater than white infants, thus suggesting a potential role for ethnic-specific genetic predisposition. 6 While the pathophysiological mechanisms underlying most of these tragic deaths remain elusive, heritable cardiac arrhythmia syndromes such as long QT syndrome (LQTS), Brugada syndrome (BrS), and catecholoaminergic polymorphic ventricular tachycardia (CPVT) appear to account for 10-15% of SIDS, with the majority of SIDS related mutations being identified in the SCN5A-encoded cardiac sodium channel alpha subunit (Nav1.5) or its interacting proteins. [7][8][9][10][11][12][13][14][15] In 2002, Splawski and colleagues reported on the common African American-specific polymorphism S1103Y-SCN5A (denoted previously as S1102Y) with a prevalence of 13% among African Americans and associated with an increased risk for arrhythmia susceptibility, particularly in the context of other acquired risk factors such as medications, hypokalemia or structural heart disease.…”

Section: Introductionmentioning

confidence: 99%

Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome

Norstrand¹,

Tester²,

Ackerman³

2008

Heart Rhythm

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Section: Introductionmentioning

confidence: 99%

Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome

Norstrand¹,

Tester²,

Ackerman³

2008

Heart Rhythm

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“…This phenomenon may be explained by a delayed acquirement of proper infant-rearing skills by certain females. The trend of higher infant mortality among first borns has also been observed among humans, although the causal factorsnamely the role of maternal age and socioeconomic status-remain unclear (Mathews and MacDorman 2008).…”

Section: Infant Mortalitymentioning

confidence: 99%

Reproductive parameters of female orangutans (Pongo pygmaeus wurmbii) 1971–2011, a 40-year study at Tanjung Puting National Park, Central Kalimantan, Indonesia

Galdikas

Ashbury

2012

Primates

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This study presents reproductive parameter data gathered by direct observation over a 40-year period (1971-2011) of the provisioned free-ranging population of orangutans at Camp Leakey in Tanjung Puting National Park, Central Kalimantan, Indonesia. Age at first reproduction, interbirth interval (IBI), sex ratio at birth, and infant mortality for 19 female orangutans (11 first-generation wild-born ex-captive mothers and 8 second-generation mothers) are included in this analysis. Age at first reproduction among the first-generation mothers was similar to that among wild orangutans, while second-generation mothers had a significantly earlier age at first reproduction. IBIs were similar among first-and second-generation mothers and were significantly shorter than those recorded in studies of wild orangutan populations. There was an expected male-biased sex ratio at birth and a slightly higher than expected rate of infant mortality when compared to wild populations. Infant mortality was primarily seen among second-generation mothers who gave birth before the age of 12, and among first births of some first-generation mothers. These results lend support to the ecological energetics hypothesis, which predicts that increased diet quality leads to a faster rate of reproduction. Abstract This study presents reproductive parameter data gathered by direct observation over a 40-year period of the provisioned free-ranging population of orangutans at Camp Leakey in Tanjung Puting National Park, Central Kalimantan, Indonesia. Age at first reproduction, interbirth interval (IBI), sex ratio at birth, and infant mortality for 19 female orangutans (11 first-generation wild-born ex-captive mothers and 8 second-generation mothers) are included in this analysis. Age at first reproduction among the first-generation mothers was similar to that among wild orangutans, while second-generation mothers had a significantly earlier age at first reproduction. IBIs were similar among first-and second-generation mothers and were significantly shorter than those recorded in studies of wild orangutan populations. There was an expected male-biased sex ratio at birth and a slightly higher than expected rate of infant mortality when compared to wild populations. Infant mortality was primarily seen among second-generation mothers who gave birth before the age of 12, and among first births of some first-generation mothers. These results lend support to the ecological energetics hypothesis, which predicts that increased diet quality leads to a faster rate of reproduction.

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“…1 A study aimed at quantifying the impact of genetic disease on inpatient pediatrics and the health-care system showed that 71% of the admissions to a children's hospital had an underlying disorder with a significant genetic component. 2 A dysmorphic syndrome is defined as a pattern of congenital anomalies that are observed in combination more frequently than they are statistically likely to have occurred together by chance.…”

Section: Introductionmentioning

confidence: 99%

Dysmorphology at a distance: results of a web-based diagnostic service

et al. 2013

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and the DYSCERNE expert panel 2In 2007, the DYSCERNE pilot project funded by the European Commission Public Health Executive Agency (EU DG Sanco) aimed at setting up a network of expertise for patients with rare dysmorphic disorders. As part of DYSCERNE, a Dysmorphology Diagnostic System (DDS) was set up to enable clinicians throughout the EU to submit cases electronically for diagnosis using a secure, web-based interface, hosted at specified access points (Submitting nodes), in 26 different European countries. We report the outcome of this service for 200 cases submitted consecutively between January 2010 and 2012. Each case was reviewed by an average of five expert reviewers. An average of three possible syndromic diagnoses was suggested per case. In 22.5% of the cases, a consensus clinical diagnosis was reached. Genetic testing was suggested in 70.5% of the cases, whereas other laboratory investigations and diagnostic imaging were recommended in 35.5 and 26% of the cases, respectively. Further specialized opinions were suggested in 23.5% of the cases. Overall, a total of 181 very rare or extremely rare genetic syndromes were considered in the differential diagnosis of the 200 cases. In two cases, the reviewers suggested that the findings represented a new syndrome, and in one of these syndromes the underlying genetic cause was subsequently identified. Other benefits of the submission process included the possibility of directing the case submitters to specific centres for diagnostic testing or participation in research and educational benefit derived for both case submitters and reviewers.

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Infant Mortality Statistics from the 1999 Period: Linked Birth/Infant Death Data Set

Abstract: Objectives-This report presents 1998 period infant mortality statistics from the linked birth/infant death data set (linked file) by a variety of maternal and infant characteristics.Methods-Descriptive tabulations of data are presented.

Cited by 1,276 publications

References 42 publications

Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome

Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome

Reproductive parameters of female orangutans (Pongo pygmaeus wurmbii) 1971–2011, a 40-year study at Tanjung Puting National Park, Central Kalimantan, Indonesia

Dysmorphology at a distance: results of a web-based diagnostic service

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