Infecção cervical por papilomavírus humano: genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero

Mendonça, Vilma Guimarães de; Guimarães, Maria José Bezerra; Filho, José Luiz de Lima; Mendonça, Carolina Guimarães de; Martins, Danyelly Bruneska Gondim; Crovella, Sérgio; Alencar, Luiz Cláudio Arraes de

doi:10.1590/s0100-72032010001000002

Cited by 20 publications

(21 citation statements)

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“…These findings are consistent with Oliveira-Silva et al (2011), which in a study performed in Rio de Janeiro (with PCR for DNA-HPV detection in 297 HPV positive women), noted a prevalence of 28% for HPV-16, and 14.4% for HPV-18, differing by only a third from the most prevalent genotype, which was reported for HPV-45 (7.6%), and in our study was observed for HPV-33 (9.3%). However, Mendonça et al (2010) carried out a study with 248 women in the city of Recife, and also observed that the HPV-33 genotype was the third most prevalent (13.9%), a similar percentage to the present study. The high prevalence of oncogenic genotypes found in this study indicates the need for frequent monitoring, and suggests nPCR technique for DNA-HPV detection as an alternative to early identification of women at high risk for cervical cancer development.…”

Section: Discussionsupporting

confidence: 89%

High incidence of oncogenic HPV genotypes found in women from Southern Brazil

Entiauspe¹,

Silveira²,

Nunes³

et al. 2014

Braz. J. Microbiol.

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Oncogenic HPV genotypes are strongly associated with premalignant and malignant cervical lesion. The purpose was to determine human papillomavirus (HPV) prevalence and genotypes, and to estimate cervical cancer risk factor associations. Cervical samples were obtained from 251 women seeking gynecological care at the Pelotas School of Medicine Clinic. This is a cross-sectional study. HPV-DNA was amplified by nested-PCR using MY09/11 and GP5/6 primers, and the sequencing was used for genotyping. Sociodemographic and behavioral risk factors were obtained by closed questionnaire, and its relationship to HPV infection prevalence were analyzed. Statistical analyses were performed using SPSS 16.0 software, and differences were considered significant at p < 0.05. As results, the prevalence of HPV infection was 29.9%. The most frequent genotype was HPV-16 (41.3%), followed by HPV-18 (17.3%), and HPV-33 (9.3%). Others nine HPV genotypes were also found. On this population, prevalence of oncogenic HPV genotypes was high, but does not seem to confer relationship with the risk factors investigated. Future investigations in larger populations are necessary, for the proposition of more appropriated monitoring strategies and treatment according to the Brazilian health service reality, as well as patients.

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Section: Discussionsupporting

confidence: 89%

High incidence of oncogenic HPV genotypes found in women from Southern Brazil

Entiauspe¹,

Silveira²,

Nunes³

et al. 2014

Braz. J. Microbiol.

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“…Our results indicate that most of the women came from families with a low monthly income, mostly less than one to three times the minimum wage, which is consistent with studies that suggest that a low family income is an important factor in HPV pathogenesis and infection (10) .…”

Section: Discussionsupporting

confidence: 91%

“…Most of the infected women in this study had a low level of education, and previous studies support this association (8,10) ; however, there are conflicting data on the correlation between higher education levels and the risk of HPV infection.…”

Section: Discussionsupporting

confidence: 69%

EpidEmiological FEaturEs oF papillomatosis causEd by thE human papillomavirus in WomEn attEnding thE basic hEalthcarE clinic in nova iguaçu county, statE oF rio dE JanEiro

Barbosa¹,

Mendes²,

Silva³

et al. 2012

J Bras Doenças Sex Transm

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Introduction: viral diseases have affected humans for thousands of years; however, viruses were only recently determined to be associated with human malignant neoplasias. The discovery of the relationship between cervical cancer and the human papillomavirus (HPV) has significant implications in the health care of women. Objective: the aim of this study was to use an epidemiological survey to investigate the variables that composed the profile of female patients with suspicion of cervical HPV infection who attended Nova Iguaçu General Hospital (Hospital Geral de Nova Iguaçu -HGNI) in the state of Rio de Janeiro. Methods: the patients attended Nova Iguaçu General Hospital from March 2009 to February 2010 and were interviewed using a pre-established questionnaire. Results: in total, 117 patients were interviewed. Based on the data that were supplied by the attending physicians, the average patient age was 34.5 years. The patients resided in different municipalities in the state of Rio de Janeiro, and 53 (44%) of the patients resided in Nova Iguaçu county. Overall, 60 patients (51%) reported four or more sexual partners, and 17 patients (15%) reported only one partner. A total of 105 women (90%) reported that they did not use condoms with their stable partners, and 9 women (10%) reported that they always used condoms with their partners. Conclusion: women with a mean age of 34.5 years who had four or more sexual partners may be at high risk for invasive carcinoma when persistent HPV infection, especially HPV type 16, is detected in them. We conclude that cervical cancer screening is essential in women aged 25 to 59 years. Keywords: epidemiology, diagnosis, HPV, STD RESUMO Introdução: as doenças virais têm afetado o homem há milhares de anos; porém, o conhecimento de vírus que promovem o desenvolvimento de neoplasias malignas humanas é bem recente. Foi de suma importância, para a saúde das mulheres, a descoberta da relação entre o câncer de colo uterino e o papilomavírus humano (HPV). Objetivo: o objetivo deste trabalho foi pesquisar, através de inquérito epidemiológico, as variáveis relacionadas ao perfil das pacientes com suspeitas de HPV de colo de útero atendidas no Hospital Geral de Nova Iguaçu, no estado do Rio de Janeiro. Métodos: as pacientes atendidas no Hospital Geral de Nova Iguaçu (HGNI) no período de março/2009 a fevereiro/2010 foram entrevistadas através de questionário preestabelecido. Resultados: ao todo, 117 pacientes foram entrevistadas. Baseando-se nos dados fornecidos pelo médico responsável, pode-se observar que a média de idade era de 34,5 anos, e que as pacientes eram originárias de diversos municípios do estado do Rio de Janeiro, sendo 53 (44%) do município de Nova Iguaçu. Quanto ao número de parceiros sexuais, 60 mulheres (51%) apresentaram quatro ou mais parceiros e 17 mulheres (15%) relataram relações com apenas um parceiro. 105 mulheres (90%) relataram não usar preservativo com o parceiro permanente e nove mulheres (10%) descreveram o uso contínuo do preservativo com seus respectiv...

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“…The other 20% can progress to lesions that precede cervical cancer (2) . The relationship between HPV and carcinogenesis depends mainly on the type of virus and its persistence and integration with the host cell (3) . Currently, there are more than 200 known types of HPV, of which about 40 infect the genital tract.…”

Section: Introductionmentioning

confidence: 99%

Frequency and genotyping of human papillomavirus in women submitted to citology

Silva¹,

Vietta²,

Golfetto³

et al. 2015

J Bras Doenças Sex Transm

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Introduction: Among the sexually transmitted virus, the human papilloma virus (HPV) is the most prevalent and may be detected a considerable number of sexually active women. He is considered the main agent of cervical cancer. Therefore, the high-risk HPV identification can aid in the prevention of cervical lesions. Objective: To evaluate the occurrence of HPV infections, comparing different methodologies, as well as some risk factors and their potential association in the development of cervical cancer in women submitted to cytopathology treated in ambulatory Unit Family and Community Health (USFC) of the University of Vale do Itajaí (UNIVALI). Methods: 118 samples were evaluated sexually active women who sought care for screening of cervical cancer in USFC and UNIVALI. All samples were subjected to polymerase chain reaction (PCR) and the liquid and conventional cytology. However, only 64 women were subjected to hybrid capture methodology (CH2). Results: The prevalence of HPV was 43.22% by PCR and 25% for CH2; analysis of the results was observed association between HPV and the following variables: ethnicity (p<0.016), scholarity (p<0.012), human immunodeficiency virus (HIV) (p<0.008), preservative (p<0.02), oral contraceptives (p<0.03), younger age at first sexual intercourse (p<0.07), conventional cytology (p<0.002) and liquid cytology (p<0.029). Conclusion: The incidence of HPV infection is high and the high-risk HPV was primarily associated with the younger age at first sexual intercourse. Keywords: papillomaviridae; polymerase chain reaction; sexually transmitted diseases. RESUMOIntrodução: Dentre os vírus de transmissão sexual, o papilomavírus humano (HPV) é o mais prevalente, podendo ser detectado em considerável número de mulheres sexualmente ativas. Ele é considerado o principal agente causador do câncer do colo do útero. Portanto, a identificação do HPV de alto risco pode auxiliar na prevenção de lesões do colo uterino. Objetivo: Avaliar a ocorrência de infecções pelo HPV, comparando diferentes metodologias, assim como alguns fatores de risco e seu potencial de associação no desenvolvimento do câncer do colo uterino em mulheres submetidas à citopatologia atendidas nos ambulatórios da Unidade de Saúde Familiar e Comunitária (USFC) da Universidade do Vale do Itajaí (UNIVALI). Métodos: Foram avaliadas 118 amostras de mulheres sexualmente ativas que buscaram atendimento para rastreio do câncer cervical na USFC e da UNIVALI. Todas as amostras foram submetidas à reação em cadeia da polimerase (PCR) e às citologias líquida e convencional. Entretanto, apenas 64 mulheres foram submetidas à metodologia de captura híbrida (CH2). Resultados: A prevalência do HPV foi de 43,22% pela técnica de PCR e de 25% pela CH2; na análise dos resultados observou-se associação do HPV com as seguintes variáveis: etnia (p<0,016), escolaridade (p<0,012), vírus da imunodeficiência humana (HIV) (p<0,008), preservativo (p<0,02), anticoncepcional (p<0,03), início da atividade sexual (p<0,07), citologia convencional (p<0,002) e...

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Infecção cervical por papilomavírus humano: genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero

Cited by 20 publications

References 0 publications

High incidence of oncogenic HPV genotypes found in women from Southern Brazil

High incidence of oncogenic HPV genotypes found in women from Southern Brazil

EpidEmiological FEaturEs oF papillomatosis causEd by thE human papillomavirus in WomEn attEnding thE basic hEalthcarE clinic in nova iguaçu county, statE oF rio dE JanEiro

Frequency and genotyping of human papillomavirus in women submitted to citology

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