Infecção do trato urinário em gestantes: avaliação da susceptibilidade dos uropatógenos aos antimicrobianos em uroculturas positivas/Urinary tract infection in pregnant women: assessing uropatogen susceptibility to antimicrobials in positive urocultures

Abstract

Introduction: Urinary tract infection (UTI) is a common condition in women, especially pregnant women due to the anatamo-physiological changes that occur in their body. Uroculture and Antimicrobial Sensitivity Tests (AST) continue to be the most important diagnostic methods for guiding therapeutic management. Objective: To analyze the prevalence of uropathogens responsible for UTI in pregnant women and their susceptibility profile to the main antimicrobials used in the treatment, in the city of Aracaju-SE. Methodology: This is a retrospective epidemiological study with a cross-sectional design, referring to data linked to urine cultures of pregnant women. The current study analyzed 8066 urine cultures from a microbiological laboratory in the city of Aracaju-SE between May/2018 to May/2020, in order to learn about the etiologic agents of UTI in pregnant women and their respective susceptibility profiles to antimicrobials. Results: As for the increase in microorganisms, Escherichia coli prevailed in 87% of positive urine cultures, followed by other Gram-negative and Gram-positive bacteria. As for susceptibility to antimicrobials, drugs suggested by the FEBRASGO protocol were tested, where it was possible to show a better performance of the so-called first choice antimicrobials such as phosphomycin and nitrofurantoin. Conclusion: Escherichia coli was the uropathogen that prevailed in positive urine cultures in pregnant women. The uropathogens aggregate indices of sensitivity to Fosfomycin and Nitrofurantoin, which makes it safe in its use as first line drugs. As for Amoxicillin/Clavulanate and Cefuroxime, the results are not homogeneous for microbial species, suggesting higher failure rates when compared to the first choice.

Fatores Relacionados À Infecção De Trato Urinário Na Gestação

“…Evidenciou-se que os conhecimentos das gestantes sobre o tema e as práticas de cuidado com a saúde precisam ser fortalecidos. (Menezes et al, 2020).…”

Perfil Epidemiológico De Gestantes Atendidas Em Uma Unidade Básica De Saúde De Um Município Da Região Metropolitana De Curitiba-Paraná

“…Embora possa ser frequente no período de gestação, a infecção de trato urinário teve baixo índice entre as gestantes pesquisadas, apenas 4,3% (n=2). Os motivos que contribuem para este tipo de infecção durante a gravidez, podem estar associados as mudanças anatômicas e fisiológicas do trato urinário, além das mudanças hormonais como a progesterona e estrogênio aumentam levando assim a diminuição da capacidade do trato urinário a resistir a invasão de bactéria 22 .…”

Bacteriúria e infecção urinária em gestantes adolescentes: fatores de risco, modelos preditivos, desfechos obstétricos e perfil bacteriano comparativo

“…e Pseudomonas sp.) em uroculturas de gestantes, de [186][187][188][189][190][192][193][194][197][198][199][201][202][203][204][205][206][207][208][209][211][212][213]215,218,220) 7352 288…”

“…2.8 (1.9-3.9) 77% (<0.01) 0.024 Enterobacter sp (28,59,67,73,74,76,79,81,83,(86)(87)(88)(89)(90)(94)(95)(96)(98)(99)(100)(101)(102)105,106,108,110,111,113,(115)(116)(117)122,125,126,145,(147)(148)(149)159,161,166,(186)(187)(188)(189)(190)(191)(192)(193)(194)(197)...…”

“…1.4 (0.5-2.5) 89% (<0.01) 0.015 Streptococcus agalactiae (28,59,67,73,74,76,79,81,83,87,89,90,(94)(95)(96)98,99,101,102,105,106,108,110,111,113,(115)(116)(117)122,125,126,145,(147)(148)(149)159,161,166,(187)(188)(189)(190)(192)(193)(194)(197)(198)(199)(201)(202)(203)…”