Infecciones del tracto urinario: sensibilidad antimicrobiana y seguimiento clínico

Collantes, Carmen de Lucas; Alvargonzalez, J. Cela; Chacón, A.M. Angulo; Ascaso, M. García; Pérez, Roi Piñeiro; Ortega, María José Cilleruelo; Romero, Isabel Sánchez

doi:10.1016/j.anpedi.2011.10.002

Cited by 11 publications

(6 citation statements)

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“…E. coli predominated among the isolated agents, accounting for 60% of the positive cultures. This value is lower than that found in a number of international studies and similar to that obtained in Brazilian studies 1 , 5 , 8 , 9 , 11 , which might reveal a local characteristic, reaffirming the need to know the regional profile in order to choose the correct antibiotic and course of empirical treatment.…”

Section: Discussionsupporting

confidence: 67%

Antibiotic Resistance Patterns of Urinary Tract Infections in a Northeastern Brazilian Capital

Cunha

Assunção

Medeiros

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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Urinary tract infection is a common problem worldwide. Its clinical characteristics and susceptibility rates of bacteria are important in determining the treatment of choice and its duration. This study assessed the frequency and susceptibility to antimicrobials of uropathogens isolated from community-acquired urinary tract infections in the city of Natal, Rio Grande do Norte State capital, northeastern Brazil, from 2007 to 2010. A total of 1,082 positive samples were evaluated; E. coli was the most prevalent pathogen (60.4%). With respect to the uropathogens susceptibility rates, the resistance of enterobacteria to ciprofloxacin and sulfamethoxazole-trimethoprim was 24.4% and 50.6%, respectively. Susceptibility was over 90% for nitrofurantoin, aminoglycosides and third-generation cephalosporins. High resistance rates of uropathogens to quinolones and sulfamethoxazole-trimethoprim draws attention to the choice of these drugs on empirical treatments, especially in patients with pyelonephritis. Given the increased resistance of community bacteria to antimicrobials, local knowledge of susceptibility rates of uropathogens is essential for therapeutic decision making regarding patients with urinary tract infections.

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Section: Discussionsupporting

confidence: 67%

Antibiotic Resistance Patterns of Urinary Tract Infections in a Northeastern Brazilian Capital

Cunha

Assunção

Medeiros

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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“…Its resistance to ampicillin is 44.8-54.9%, 5.7-21.7% to amoxicillin-clavulanate, 1.2-4% to cephuroxim, 1-4.7% to nitrofurantoin and 19-31.3% to cotrimoxazole. 8 There is high rates of resistance of this agent to cotrimoxazole, already described in other studies 3,9 probably as consequence of indiscriminate use of this drug in the past. Uropathogens other than Escherichia coli were more prevalent in children and adolescents with uropathy and there were no differences between those under prophylaxis.…”

mentioning

confidence: 81%

“…[2][3][4] Antibiotic resistance and multi-drug resistant infection, driven by antibiotic use, remain a major public health and professional concern.…”

Section: Introductionmentioning

confidence: 99%

“…7 Due to geographic variation of uropathogens, their mechanisms of resistance and recent changes in antimicrobial resistance, it is crucial to know the prevalence of local microbial agents and their antimicrobial susceptibility profile to adjust the initial empirical treatment of UTI. [3][4] During the last decades there is concern in treating acute pyelonephritis (APN) at lowest cost and with maximum effectiveness. The aim Revista Científica da Ordem dos Médicos www.actamedicaportuguesa.com…”

Section: Introductionmentioning

confidence: 99%

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Etiological Agents and Antimicrobial Susceptibility in Hospitalized Children with Acute Pyelonephritis

et al. 2015

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: 1994-1997, G2: 2002; G3: 2007; G4: 2012). Resultados: Avaliámos 581 doentes, 66% do sexo feminino, com idade mediana de 22 meses. A Escherichia coli foi o principal uropatógeno e a sua prevalência manteve-se estável durante os últimos 18 anos. Verificou-se um aumento da sensibilidade à amoxicilina/ácido clavulânico de 71% no G1 para 81,5% no G4 (p = 0,001) e uma diminuição da taxa de resistência de 8,7% no G1 para 2,8% G4 (p = 0,008). A sua sensibilidade às cefalosporinas de segunda e terceira geração e nitrofurantoína foi superior a 90% (p = ns). A taxa de resistência ao cotrimoxazol aumentou de 22 % para 26 % (p = 0,008). Discussão: A Escherichia coli continua a ser o uropatogénio mais frequente responsável por pielonefrite aguda, motivo pelo qual o seu perfil de sensibilidade aos antimicrobianos determina a escolha da antibioticoterapia empírica. Conclusões: A amoxicilina/ácido clavulânico mantém-se como escolha de primeira linha para o tratamento empírico da pielonefrite aguda em regime de internamento. Palavras-Chave: Pielonefrite; Antibacterianos; Crianças; Farmacorresistência Bacteriana. ABSTRACT Introduction:Antibiotic resistance driven by antibiotic use remains a major public health and professional concern. Our aim was to know the local prevalence of uropathogens and their antimicrobial susceptibility profile in acute pyelonephritis. Material and Methods:A prospective study of patients admitted in a level III Pediatric Department ward with acute pyelonephritis from 1994 to 2012 was performed in Northern Portugal. Etiological agents and their antimicrobial sensitivity profile were evaluated in four timed periods (G1: 1994-97; G2: 2002; G3: 2007; G4: 2012). Results:We evaluated 581 patients, 66% female with median age 22 months. Escherichia coli was the leading uropathogen and its prevalence remained stable during the last 18 years. It showed an increased sensitivity to amoxicillin-clavulanate from 71% in G1 to 81.5% in G4 (p = 0.001) and a decreased resistance rate from 8.7% in G1 to 2.8% in G4 (p = 0.008). Its sensitivity to 2nd and 3rd generation cephalosporin was more than 90% (p = ns) and more than 95% to nitrofurantoin (p = ns). Resistance rate of cotrimoxazole increased from 22% to 26% (p = 0.008). Discussion: Escherichia coli remains the main uropathogen responsible for acute pyelonephritis, reason why its antimicrobial sensitivity profile will determine the empirical therapeutic choice. Conclusions: Amoxicillin-clavulanate remains a good first-line choice for empirical treatment of acute pyelonephritis in our inpatient health care.

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“…Para ello, además de determinar la frecuencia de complicaciones, es esencial conocer los microorganismos responsables y su sensibilidad antibiótica. En España son escasos los estudios al respecto en este grupo de edad 12,14 .…”

Section: Introductionunclassified

Etiología y curso clínico de la infección del tracto urinario en los lactantes menores de 3 meses

Hernández-Bou

Maza

Gamarra

et al. 2015

Enfermedades Infecciosas y Microbiología Clínica

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Infecciones del tracto urinario: sensibilidad antimicrobiana y seguimiento clínico

Cited by 11 publications

References 11 publications

Antibiotic Resistance Patterns of Urinary Tract Infections in a Northeastern Brazilian Capital

Antibiotic Resistance Patterns of Urinary Tract Infections in a Northeastern Brazilian Capital

Etiological Agents and Antimicrobial Susceptibility in Hospitalized Children with Acute Pyelonephritis

Etiología y curso clínico de la infección del tracto urinario en los lactantes menores de 3 meses

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