Infecciones respiratorias, síndrome de Down y cardiopatías congénitas: Estudio CIVIC 21

Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus

“…These lower RTIs are most often caused by viral pathogens, such as respiratory syncytial virus (RSV). This can lead to severe RSV bronchiolitis which in its turn is a frequent cause of hospitalization in DS children [7][8][9][10]. Very recently, it was shown that children with DS also have an increased risk of hospitalization, endotracheal intubation, and death due to influenza A virus infection [11].…”

Pandemic (H1N1) 2009 Virus and Down Syndrome Patients

“…In addition, specific alterations in immune response are frequently present, including leukopenia, chemotactic defects ( 6 ), decreased immunoglobulin G 4 levels ( 7 ), and T- and B-cell abnormalities ( 7 , 8 ) with reduced B lymphocytes ( 9 ). Patients with Down syndrome have an increased need for hospitalization because of lower respiratory tract disease caused by respiratory syncytial virus ( 10 ) and other respiratory infections ( 11 ) as well as reduced access to healthcare ( 12 ). An increased proportion of patients with Down syndrome have pneumonia as cause of death ( 13 ).…”

Increased production of interleukin-10 in children with Down syndrome upon ex vivo stimulation with Streptococcus pneumoniae

“…These lower RTIs in DS children are most often caused by viral pathogens, such as respiratory syncytial virus. This can lead to severe respiratory syncytial virus bronchiolitis, a frequent cause of hospitalization in DS children (10,(26)(27)(28). Also, an increased risk of hospitalization, endotracheal intubation, and death due to influenza A virus infection was reported in DS (29).…”