Endodontics is a unique branch in dentistry that often deals with endodontic emergencies. In the course of this COVID-19 pandemic, Emergency Root Canal Treatment is often needed to treat symptomatic irreversible pulpitis with or without space infections. Since dental practitioners cannot often maintain a safe interpersonal distance of more than a meter and are exposed to saliva, blood, and other body fluids during surgical operations, they are especially vulnerable to SARS-CoV-2 infection. Furthermore, many dental procedures produce aerosol, increasing the risk of contamination spread through the breath. The aim of this paper is to provide dentists with realistic advice based on recent research that may be helpful in reducing the risk of COVID-19 spreading during clinical practice.