2000
DOI: 10.4049/jimmunol.164.12.6417
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Infection of B Cell-Deficient Mice with CDC 1551, a Clinical Isolate ofMycobacterium tuberculosis: Delay in Dissemination and Development of Lung Pathology

Abstract: Long-term survival of mice infected with Mycobacterium tuberculosis is dependent upon IFN-γ and T cells, but events in early phases of the immune response are not well understood. In this study, we describe a role for B cells during early immune responses to infection with a clinical isolate of M. tuberculosis (CDC 1551). Following a low-dose infection with M. tuberculosis CDC 1551, similar numbers of bacteria were detected in the lungs of both B cell knockout (IgH 6−, BKO) and C57BL/6J (wild-type) mice. Howev… Show more

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Cited by 139 publications
(107 citation statements)
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“…46 Other studies have demonstrated that B cells can improve protection against mycobacteria, regardless of the antibody production, that is, such cells could be antigen-presenting cells. 47 This protection could be confirmed by the finding that higher levels of antibodies are related to better prognosis 48 ; however, Sant'Anna et al 49 found higher levels of antibodies correlated with higher disease severity in Brazil. Nevertheless, children with TB are likely to present lower titers than adults.…”
Section: Immunology and Pathogenesissupporting
confidence: 52%
“…46 Other studies have demonstrated that B cells can improve protection against mycobacteria, regardless of the antibody production, that is, such cells could be antigen-presenting cells. 47 This protection could be confirmed by the finding that higher levels of antibodies are related to better prognosis 48 ; however, Sant'Anna et al 49 found higher levels of antibodies correlated with higher disease severity in Brazil. Nevertheless, children with TB are likely to present lower titers than adults.…”
Section: Immunology and Pathogenesissupporting
confidence: 52%
“…Despite this controversy, studies by our group and others have found that B cells can influence tuberculosis (TB) 3 susceptibility and pathologic progression in murine models (3)(4)(5). Moreover, the efficacy of specific mAbs (6 -8) and arabinomannan conjugate vaccines (9) against M. tuberculosis infection indicate that B cell biology may be augmented to enhance protection during TB.…”
mentioning
confidence: 99%
“…[21][22][23][24] Several studies have demonstrated that the spectrum of specificities of antimycobacterial antibodies was much narrower in B6 and B10 inbred mice as compared to several other inbred strains. 25,26 These differences were observed after infection with live MTB and BCG as well as after immunization with antigenic preparations of mycobacteria.…”
Section: Resultsmentioning
confidence: 99%
“…B lymphocytes have been recently shown to play a role in resistance to intracellular pathogens that is distinct from their antibody-producing function. 23,27 Previously, the IgH b allotype has been associated with anergy and pulmonary granulomatous inflammation early after systemic injection of M. bovis BCG. 28,29 To start addressing B cell function in our model, we compared B lymphocytes in tuberculosis lung lesions in the parental B6 and C3H.B6-sst1 mice.…”
Section: Resultsmentioning
confidence: 99%