Infections fongiques et granulomatose septique chronique

Desjardins, Anne E.; Coignard-Biehler, Hélène; Mahlaoui, Nizar; Frange, Pierre; Bougnoux, Marie‐Elisabeth; Blanche, Stéphane; Fischer, Alain; Blumental, Sophie; Lortholary, Olivier

doi:10.1051/medsci/20122811015

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…In contrast to combined immune deficiencies (CID) or severe combined immune deficiencies (SCID) affecting more or less the entire lymphocyte lineage, subjects with neutrophilic immunodeficiency syndromes (NIDs), such as chronic septic granulomatosis, are not (or only slightly) at risk of developing a PCP [90]. Using an animal model, Swain et al found no increased susceptibility to PCP in the case of quantitative depletion of polymorphonuclear cells (PMN) in the lungs (CXCR2 KO) or qualitative depletion of reactive oxygen production by PMN (GP91phox KO, phox/INOS KO) [91].…”

Section: Other Immune Cell Depletionsmentioning

confidence: 99%

Immune Response in Pneumocystis Infections According to the Host Immune System Status

Charpentier

Ménard

Marques

et al. 2021

JoF

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The host immune response is critical in Pneumocystis pneumonia (PCP). Immunocompetent hosts can eliminate the fungus without symptoms, while immunodeficient hosts develop PCP with an unsuitable excessive inflammatory response leading to lung damage. From studies based on rodent models or clinical studies, this review aimed to better understand the pathophysiology of Pneumocystis infection by analysing the role of immune cells, mostly lymphocytes, according to the immune status of the infected host. Hence, this review first describes the immune physiological response in infected immunocompetent hosts that are able to eliminate the fungus. The objective of the second part is to identify the immune elements required for the control of the fungus, focusing on specific immune deficiencies. Finally, the third part concentrates on the effect of the different immune elements in immunocompromised subjects during PCP, to better understand which cells are detrimental, and which, on the contrary, are beneficial once the disease has started. This work highlights that the immune response associated with a favourable outcome of the infection may differ according to the immune status of the host. In the case of immunocompetency, a close communication between B cells and TCD4 within tertiary lymphocyte structures appears critical to activate M2 macrophages without much inflammation. Conversely, in the case of immunodeficiency, a pro-inflammatory response including Th1 CD4, cytotoxic CD8, NK cells, and IFNγ release seems beneficial for M1 macrophage activation, despite the impact of inflammation on lung tissue.

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Section: Other Immune Cell Depletionsmentioning

confidence: 99%

Immune Response in Pneumocystis Infections According to the Host Immune System Status

Charpentier

Ménard

Marques

et al. 2021

JoF

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Fulminant mulch pneumonitis in a previously healthy child

Mâaloul

Ameur

Chabchoub

et al. 2018

Archives de Pédiatrie

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Identification of a Novel Mutation in the CYBB Gene, p.Asp378Gly, in a Patient With X-linked Chronic Granulomatous Disease

Song

Park

Kim

et al. 2014

Allergy Asthma Immunol Res

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Chronic granulomatous disease (CGD) is a rare immunodeficiency disease, which is characterized by the lack of a functional nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. The disease presents leukocytosis, anemia, hypergammaglobulinemia, and granuloma formation of the skin, lung, or lymph nodes. The mutation of the CYBB gene encoding gp91phox, located on chromosome Xp21.1 is one of the causes of CGD. We report a patient with X-linked CGD who carried a novel mutation, a c.1133A>G (paAsp378Gly) missense mutation, in the CYBB gene.

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Infections fongiques et granulomatose septique chronique

Cited by 3 publications

References 33 publications

Immune Response in Pneumocystis Infections According to the Host Immune System Status

Immune Response in Pneumocystis Infections According to the Host Immune System Status

Fulminant mulch pneumonitis in a previously healthy child

Identification of a Novel Mutation in the CYBB Gene, p.Asp378Gly, in a Patient With X-linked Chronic Granulomatous Disease

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