Infectious Diseases

Reichenbach-Klinke, H.

doi:10.1016/b978-1-4832-3303-1.50015-9

Cited by 2 publications

(1 citation statement)

References 66 publications

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“…Although a range of spontaneous tumors have been described in Xenopus over the years, from hepatomoa, teratoma, renal carcinoma, fibroma, fibrosarcoma, ovarian dysgerminoma, melanophoroma, lymphoma (reviewed in [1, 32]) to pancreatic carcinoma [33], deriving tumor cell lines, crucial for tumor immunity studies, has been met with limited success. A notable exception, however, is isolation and characterization of several transplantable lymphoid tumor lines that were derived from spontaneous thymic tumors [34].…”

Section: Integrating Nonmammalian Models For Studying Defenses Againsmentioning

confidence: 99%

Tumor Immunology Viewed from Alternative Animal Models—the Xenopus Story

Banach

Robert

2017

Curr Pathobiol Rep

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a) Purpose of review Nonmammalian comparative animal models are important not only to gain fundamental evolutionary understanding of the complex interactions of tumors with the immune system, but also to better predict the applicability of novel immunotherapeutic approaches to humans. After reviewing recent advances in developing alternative models, we focus on the amphibian Xenopus laevis and its usefulness in deciphering the perplexing roles of MHC class I-like molecules and innate (i)T cells in tumor immunity. b) Recent findings Experiments using MHC-defined inbred and cloned animals, tumor cell lines, effective reagents, sequenced genomes, and adapted gene editing techniques in Xenopus, have revealed that the critical involvement of class I-like molecules and iT cells in tumor immunity has been conserved during evolution. c) Summary Comparative studies with the X. laevis tumor immunity model can contribute to the development of better and more efficient cancer immunotherapies.

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Section: Integrating Nonmammalian Models For Studying Defenses Againsmentioning

confidence: 99%