Infective endocarditis of an interventricular patch caused byAcinetobacter haemolyticus

Castellanos, Eduardo; Asensio, Mauricio Telenti; Blanco, Víctor María Fernández; Suárez, Marina; Torrico, A Morena; Llosa, Arturo Cortina

doi:10.1007/bf01781207

Cited by 17 publications

(8 citation statements)

References 12 publications

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“…One strain was A. haemolyticus, isolated from an 86-yearold male patient suffering from recurrent bronchiectasis, the other was A. lwof®i, responsible for septicaemia in a 5-year-old female patient. Both A. haemolyticus and A. lwof®i are known to cause systemic infections [25,26]. Four isolates were closely related to phenotype A. lwof®i and one resembled the typical A. haemolyticus phenotype.…”

Section: Antimicrobial Susceptibility Testingmentioning

confidence: 97%

Simplified phenotypic tests for identification of Acinetobacter spp. and their antimicrobial susceptibility status

Prashanth

Badrinath

2000

Journal of Medical Microbiology

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Acinetobacter spp. have been found to be responsible for an increasing number of nosocomial infections. During a 16-month period, 22 patients hospitalised mainly in the respiratory intensive care unit (RICU), paediatric and other medical wards were investigated either for infection or colonisation by Acinetobacter spp. Of the 45 isolates of Acinetobacter detected among the total of 425 non-fermenters encountered, 24 representative isolates were selected for extended phenotypic identi®cation. Four environmental isolates were also included in the study. These 28 isolates were typed by biotyping and antibiotyping, which helped in delineating the Acinetobacter spp. into 12 phenotypes and two distinct antibiotypes respectively. A sudden increase of cases of acinetobacter infection suggested that three outbreaks during the study period were due to phenotypes 1 and 2 of A. calcoaceticus-A. baumannii complex (Acb). Strains of Acbcomplex showed multiple drug resistance and were sensitive only to netilmicin. A comparatively high proportion of resistance to amikacin (48%) was also detected among these strains by the agar dilution method. The RICU environment was recognised as an important reservoir for the resistant outbreak strain (Acb-1) which was probably leading to persistent colonisation and recurrent infections.

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Section: Antimicrobial Susceptibility Testingmentioning

confidence: 97%

Simplified phenotypic tests for identification of Acinetobacter spp. and their antimicrobial susceptibility status

Prashanth

Badrinath

2000

Journal of Medical Microbiology

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“…They are the second most commonly isolated nonfermenters in human specimens (81), after Pseudomonas aeruginosa and their incidence is on the increase and mortality rates are quite high (56,111,119). A. baumannii was found to be associated with a series of fatal cases of community pneumonia (29) and A. haemolyticus, with endocarditis and verotoxin production, and hence bloody diarrhea (11,17,47). Pathogenic mechanisms.…”

Section: Pathogenesis Virulence Factors and Resistancementioning

confidence: 99%

The Ecology, Biology and Pathogenesis of Acinetobacter spp.: An Overview

et al. 2011

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Acinetobacter are a major concern because of their rapid development of resistance to a wide range of antimicrobials, and rapid profundity in transformation, surviving desiccation and persistinge in the environment for a very long time. The organisms are associated with bacteraemia, pulmonary infections, meningitis, diarrhea and notorious nosocomial infections with mortality rates of 20 to 60%. Transmission is via person-to-person contact, water and food contamination, and contaminated hospital equipment. The increasing virulence and rapid development of multidrug resistance by these organisms highlights the need to search for alternatives for chemotherapy. A poor understanding of the organisms and dearth of information about their occurrence especially in developing countries informed the need for this review paper.

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“…Among these Acinetobacter species, Acinetobacter baumannii is the most clinically important pathogen because it is involved in nosocomial infections and often exhibits multidrug resistance, particularly to carbapenems [ 3 4 5 ]. Non- baumannii Acinetobacter species have been isolated from patients with bacteremia, endocarditis, and meningitis [ 6 7 8 ]. The clinical features and antibiotic susceptibilities of A. baumannii are different from those of non- baumannii Acinetobacter species.…”

Section: Introductionmentioning

confidence: 99%

Identification of Acinetobacter Species Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

et al. 2016

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BackgroundAcinetobacter baumannii has a greater clinical impact and exhibits higher antimicrobial resistance rates than the non-baumannii Acinetobacter species. Therefore, the correct identification of Acinetobacter species is clinically important. Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) has recently become the method of choice for identifying bacterial species. The purpose of this study was to evaluate the ability of MALDI-TOF MS (Bruker Daltonics GmbH, Germany) in combination with an improved database to identify various Acinetobacter species.MethodsA total of 729 Acinetobacter clinical isolates were investigated, including 447 A. baumannii, 146 A. nosocomialis, 78 A. pittii, 18 A. ursingii, 9 A. bereziniae, 9 A. soli, 4 A. johnsonii, 4 A. radioresistens, 3 A. gyllenbergii, 3 A. haemolyticus, 2 A. lwoffii, 2 A. junii, 2 A. venetianus, and 2 A. genomospecies 14TU. After 212 isolates were tested with the default Bruker database, the profiles of 63 additional Acinetobacter strains were added to the default database, and 517 isolates from 32 hospitals were assayed for validation. All strains in this study were confirmed by rpoB sequencing.ResultsThe addition of the 63 Acinetobacter strains' profiles to the default Bruker database increased the overall concordance rate between MALDI-TOF MS and rpoB sequencing from 69.8% (148/212) to 100.0% (517/517). Moreover, after library modification, all previously mismatched 64 Acinetobacter strains were correctly identified.ConclusionsMALDI-TOF MS enables the prompt and accurate identification of clinically significant Acinetobacter species when used with the improved database.

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Infective endocarditis of an interventricular patch caused byAcinetobacter haemolyticus

Cited by 17 publications

References 12 publications

Simplified phenotypic tests for identification of Acinetobacter spp. and their antimicrobial susceptibility status

Simplified phenotypic tests for identification of Acinetobacter spp. and their antimicrobial susceptibility status

The Ecology, Biology and Pathogenesis of Acinetobacter spp.: An Overview

Identification of Acinetobacter Species Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

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