Inferences of glia‐mediated control in Caenorhabditis elegans

Abstract

Patients with major depressive disorder (MDD) have fewer astrocytes in the brain (Rajkowska & Stockmeier, 2013; Sanacora & Banasr, 2013), and astrocytes in MDD patients have an altered morphology that is associated with reduced functional vigor (Wang et al., 2017). Astrocytes maintain homeostasis in the brain and modulate synapse formation by mediating neurotransmitter and gliotransmitter release (Eroglu & Barres, 2010;