Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress

Boeck, Christina; Koenig, Alexandra M.; Schury, Katharina; Geiger, Martha Leonie; Karabatsiakis, Alexander; Wilker, Sarah; Waller, Christiane; Gündel, Harald; Fegert, Jörg M.; Calzia, Enrico; Kolassa, Iris‐Tatjana

doi:10.1016/j.mito.2016.08.006

Cited by 103 publications

(126 citation statements)

References 66 publications

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“…Long-term alterations in the regulation of the HPA axis and its final product, cortisol, are a known consequence of the enormous stress caused by maltreatment during childhood (Carpenter et al, 2007), and are linked to health outcomes such as cancer and cardiovascular and metabolic diseases (Kumari, Shipley, Stafford, & Kivimaki, 2011; Volden & Conzen, 2013). Furthermore, chronic inflammatory processes, encompassing increased levels of pro-inflammatory cytokines and oxidative stress, are a demonstrated long-term consequence of child maltreatment (Boeck et al, 2016) and are known to play a role in the pathomechanisms of cancer (Taniguchi & Karin, 2018), cardiovascular diseases (Harrington, 2017), diabetes and other metabolic diseases (Herder et al, 2016). As well as biological mechanisms, socioeconomic and behavioural aspects are considered to be relevant for the demonstrated link between child maltreatment and health conditions in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Clemens

Huber‐Lang

Plener

et al. 2018

European Journal of Psychotraumatology

100

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Background: Child maltreatment is a major public problem, associated with enormous consequences on the individual and socioeconomic level. Studies show a clear impact of child maltreatment on long-term physical health. However, there is a lack of analyses comprising a wide variety of subtypes of maltreatment and addressing cumulative effects of different maltreatment subtypes experienced during childhood on physical health. Objective: The objective of this analysis was to assess the association of different subtypes and the intensity of child maltreatment with long-term physical health outcomes. Methods: In a cross-sectional observational approach, a representative sample of the German population (N=2510) was assessed regarding socioeconomic information, their current health status, and their experiences of child maltreatment using the Childhood Trauma Questionnaire (CTQ). Chi2-Tests were performed to compare differences of physical health conditions in adulthood in association with child maltreatment and binary regression analyses to assess the relationship of physical health and number of different subtypes of maltreatment experienced during childhood. Results: Odds increased significantly for obesity (1.8), diabetes (1.26), cancer (1.28), hypertension (1.16), chronic obstructive pulmonary disease (1.51), history of myocardial infarction (1.29) and stroke (1.31) with increasingenhancing number of experienced subtypes of child maltreatment. Growing intensity of each subtype of maltreatment was associated with higher rates of all assessed physical health conditions, which could point towards a dose-dependency of the relationship between maltreatment and long-term physical health. Conclusions: Child maltreatment is associated with increased odds for the leading morbidity and mortality causes in Germany. Interventions encompassing secondary and primary preventive strategies are critical to target this major public health problem and its devastating consequences.

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Section: Discussionmentioning

confidence: 99%

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Clemens

Huber‐Lang

Plener

et al. 2018

European Journal of Psychotraumatology

100

View full text Add to dashboard Cite

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“…[17,93] Moreover, sustained GR signaling and chronic HPA-axis activation resulting in hyperglycemia can cause excessive mitochondrial fragmentation. [95] This cascade may be at the root of the ELS effects on the mitochondria. [17] Although excessive glucocorticoid levels can increase oxidative stress implicated in mitochondrial dysfunction, [94] understanding mitochondrial ROS as intracellular signaling molecules rather than deleterious byproducts of cellular respiration can explain how they may increase mitochondrial content as a compensatory response to meet energy demands of the cell following glucocorticoid exposure.…”

Section: How Does Resilience Affect Biologic Findings After Early Lifmentioning

confidence: 99%

“…[88] For example, chronic caregiving stress is correlated with lower mitochondrial respiratory chain capacity but not mtDNAcn. [95] Additionally, preliminary evidence suggests that childhood adversity may affect the mitochondria through epigenetic pathways. [97] Child maltreatment is associated with altered mitochondrial functioning, higher oxidative stress, and a pro-inflammatory phenotype.…”

Section: How Does Resilience Affect Biologic Findings After Early Lifmentioning

confidence: 99%

Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress

2018

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This manuscript reviews recent evidence supporting the utility of telomeres and mitochondrial DNA copy number (mtDNAcn) in detecting the biological impacts of adverse childhood experiences (ACEs) and outlines mechanisms that may mediate the connection between early stress and poor physical and mental health. Critical to interrupting the health sequelae of ACEs such as abuse, neglect, and neighborhood disorder, is the discovery of biomarkers of risk and resilience. The molecular markers of chronic stress exposure, telomere length and mtDNAcn, represent critical biological links between ACEs and poor health outcomes. We examine how telomeres and mtDNAcn may exacerbate health disparities and contribute to the intergenerational transmission of trauma. Finally, we explore how these molecular markers of early stress exposure may help define the role of resilience and develop effective interventions to moderate ACE health risk impact.

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“…Interestingly, as non-steroidal anti-inflammatory treatment is able to prevent delayed effects of maternal separation in rats [48], it is likely that early pharmacological interventions targeting inflammation may be effective in preventing the long-term consequences of early-life adversity in humans. Independent of facing additional social stressors, spontaneous production of proinflammatory cytokines in isolated immune cells was also higher in women with a history of childhood maltreatment [40]. Three other studies further found exaggerated IL-6 responses to ex vivo stimulation of toll-like receptors 3, 4, and 5 in adolescents raised in harsh family environments [281], in adults raised in low socioeconomic status [282] and in adolescent girls with early-life adversity [107, 112].…”

Section: Stress Inflammation and Mental Health: The Cytokine Theorymentioning

confidence: 99%

Old Friends, immunoregulation, and stress resilience

Langgartner

Lowry

Reber³

2018

Pflugers Arch - Eur J Physiol

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There is a considerable body of evidence indicating that chronic adverse experience, especially chronic psychosocial stress/trauma, represents a major risk factor for the development of many somatic and affective disorders, including inflammatory bowel disease (IBD) and posttraumatic stress disorder (PTSD). However, the mechanisms underlying the development of chronic stress-associated disorders are still in large part unknown, and current treatment and prevention strategies lack efficacy and reliability. A greater understanding of mechanisms involved in the development and persistence of chronic stress-induced disorders may lead to novel approaches to prevention and treatment of these disorders. In this review, we provide evidence indicating that increases in immune (re-)activity and inflammation, potentially promoted by a reduced exposure to immunoregulatory microorganisms (“Old Friends”) in today’s modern society, may be causal factors in mediating the vulnerability to development and persistence of stress-related pathologies. Moreover, we discuss strategies to increase immunoregulatory processes and attenuate inflammation, as for instance contact with immunoregulatory Old Friends, which appears to be a promising strategy to promote stress resilience and to prevent/treat chronic stress-related disorders.

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Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress

Cited by 103 publications

References 66 publications

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress

Old Friends, immunoregulation, and stress resilience

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