Inflammation-Related Signaling Pathways Implicating TGFβ are Revealed in the Expression Profiling of MCF7 Cell Treated with Fermented Soybean, Chungkookjang

Hwang, Jae Sung; Yoo, Hyung Jae; Song, Hye Jung; Kim, Kyu Kwang; Chun, Young Jin; Matsui, Toshiro; Kim, Han Bok

doi:10.1080/01635581.2011.551987

Cited by 32 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Soybean hydrolysates have yielded several bioactive peptides with anti-inflammatory effects on macrophage cell lines, with preparations from germinated beans eliciting the stronger responses [35]. Chungkookjang, a fermented soybean product from Korea, is rich in bioactive peptides and shows anti-inflammatory effects in breast cancer cells by downregulation of cytokine/chemokines expression and activation of transforming growth factor (TGF)-beta signaling [36]. One of the soybean-derived peptides, lunasin, appears to exert widespread anti-inflammatory effects including suppression of NF- κ B activity, reduced cytokine expression, and reduction in cyclooxygenase-2 (COX-2) levels in addition to its antioxidant and anticarcinogenic properties [37, 38].…”

Section: Bioactive Peptides On Inflammationmentioning

confidence: 99%

Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

Chakrabarti

Jahandideh

2014

BioMed Research International

315

225

View full text Add to dashboard Cite

Chronic diseases such as atherosclerosis and cancer are now the leading causes of morbidity and mortality worldwide. Inflammatory processes and oxidative stress underlie the pathogenesis of these pathological conditions. Bioactive peptides derived from food proteins have been evaluated for various beneficial effects, including anti-inflammatory and antioxidant properties. In this review, we summarize the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

show abstract

Section: Bioactive Peptides On Inflammationmentioning

confidence: 99%

Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

Chakrabarti

Jahandideh

2014

BioMed Research International

315

225

View full text Add to dashboard Cite

show abstract

“…16 Soybeans soaked for 18 h were autoclaved at 120°C for 30 min. Bacillus licheniformis B1 (1% in culture) was added onto 1 kg of autoclaved soybeans.…”

Section: Chu Preparationmentioning

confidence: 99%

Specific Oligopeptides in Fermented Soybean Extract Inhibit NF-κB-Dependent iNOS and Cytokine Induction by Toll-Like Receptor Ligands

Lee

et al. 2014

Journal of Medicinal Food

Self Cite

View full text Add to dashboard Cite

The ethanol extract of fermented soybean from Glycine max (chungkookjang, CHU) has been claimed to have chemopreventive and cytoprotective effects. In the present study, we examined the inhibitory effect of CHU on inducible nitric oxide synthase (iNOS) and cytokine induction by toll-like receptor (TLR) ligands treatment and attempted to identify the responsible active components. Nitric oxide (NO) content and iNOS levels in the media or RAW264.7 cells were measured using the Griess reagent and real-time polymerase chain reaction assays. CHU treatment inhibited NO production and iNOS induction elicited by lipopolysaccharide (LPS, TLR4L) in a concentration-dependent manner. Tumor necrosis factor-α and interleukin-6 productions were also diminished. Peptidoglycans (TLR2/6L) and CpG-oligodeoxynucleotides (TLR9L) from CHU inhibited iNOS induction, but not poly I:C (TLR3L) or loxoribine (TLF7L). The anti-inflammatory effect resulted from the inhibition of nuclear factor-kappa B (NF-κB) through the inhibition of inhibitory-κB degradation. Of the representative components in CHU, specific oligopeptides (AFPG and GVAWWMY) had the ability to inhibit iNOS induction by LPS, whereas others failed to do so. Daidzein, an isoflavone used for comparative purposes, was active at a relatively higher concentration. In an animal model, oral administration of CHU to rats significantly diminished carrageenan-induced paw edema and iNOS induction. Our results demonstrate that CHU has anti-inflammatory effects against TLR ligands by inhibiting NF-κB activation, which may result from specific oligopeptide components in CHU. Since CHU is orally effective, dietary applications of CHU and/or the identified oligopeptides may be of use in the prevention of inflammatory diseases.

show abstract

“…Few studies have been carried out the anti-inflammatory activity of peptides derived from Korean fermented soybean products (Lee et al, 2014). Hwang et al (2011) demonstrated that a bioactive peptide from chungkookjang exhibited anti-inflammatory effects in breast cancer cells by activation of transforming growth factor (TGF)-beta signaling and down-regulation of cytokine/chemokine expression. An inhibitory effect on the NO production in LPS-stimulated cells was observed in fractions of nitrogenous compounds separated by molecular weight level from water extracts of doenjang (WED) (Lee et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells

Lee

Kim

2019

Food Sci. Technol

View full text Add to dashboard Cite

The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E 2 (PGE 2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (OL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG 2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells.

show abstract

Inflammation-Related Signaling Pathways Implicating TGFβ are Revealed in the Expression Profiling of MCF7 Cell Treated with Fermented Soybean, Chungkookjang

Cited by 32 publications

References 41 publications

Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

Specific Oligopeptides in Fermented Soybean Extract Inhibit NF-κB-Dependent iNOS and Cytokine Induction by Toll-Like Receptor Ligands

Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells

Contact Info

Product

Resources

About