Inflammatory biomarkers in patients in Simvastatin treatment: No effect of co-enzyme Q10 supplementation

Hansen, Martin; Kuhlman, Anja C.B.; Sahl, Ronni Eg; Kelly, Bo; Morville, Thomas; Dohlmann, Tine Lovsø; Chrøis, Karoline Maise; Larsen, Steen; Helge, Jørn Wulff

doi:10.1016/j.cyto.2018.10.011

Cited by 16 publications

(16 citation statements)

References 42 publications

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“…Admittedly, the sample size for this experiment is very small (N = 7 Simvastatin users with myalgia); therefore, it remains possible that a beneficial effect of UQ on myalgia could be observed in a future study on a larger patient cohort. Nevertheless, other studies generally agree with our findings, indicating limited benefit of UQ towards SAM 38,52 .…”

Section: Discussionsupporting

confidence: 92%

“…In a previous study on the same cohort, we demonstrated a five-fold increase in serum levels of UQ 51 . However, here we report that mitochondrial respiration and the abundance of superoxide in blood cells were similar in Simvastatin users dosed with UQ or placebo for 8 weeks independent of the presence or absence of SAM.…”

Section: Discussionsupporting

confidence: 55%

“…As a caveat to this study, we acknowledge evidence for differential effects of statins on different tissues as has been seen demonstrated by others 47 ; it is therefore possible that statin use improves various functions of mitochondria in blood cells, as reported here, while decreasing these in skeletal muscle. We and others, have reported a decrease of inflammation markers in response to long term statin treatment 38 , 48 . It is therefore possible that the altered mitochondrial characteristica of PBMCs is linked to lower levels of inflammation.…”

Section: Discussionmentioning

confidence: 59%

“…To investigate the effects of UQ on mitochondrial respiration, 13 Simvastatin users were treated with 2 × 200 mg UQ per day for eight weeks, while 9 Simvastatin users were given a placebo 38 . Mitochondrial OCR, basal respiratory rate, ATP turnover, and reserve respiratory capacity were quantified before and after treatment with either UQ or placebo; however, the results revealed no significant differences in these mitochondrial parameters (Figure S3 ).…”

Section: Resultsmentioning

confidence: 99%

“…In the cross-sectional study statin-users with or without myalgia were compared to hypercholesteraemic controls (no therapy). The intervention consisted of eight weeks of UQ-therapy in Simvastatin-users, and controls, as described previously 38 . For practical reasons, the various cellular tests were performed on different population sizes.…”

Section: Methodsmentioning

confidence: 99%

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Simvastatin improves mitochondrial respiration in peripheral blood cells

Durhuus

Hansson

Morville

et al. 2020

Sci Rep

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Statins are prescribed to treat hypercholesterolemia and to reduce the risk of cardiovascular disease. However, statin users frequently report myalgia, which can discourage physical activity or cause patients to discontinue statin use, negating the potential benefit of the treatment. Although a proposed mechanism responsible for Statin-Associated Myopathy (SAM) suggests a correlation with impairment of mitochondrial function, the relationship is still poorly understood. Here, we provide evidence that long-term treatment of hypercholesterolemic patients with Simvastatin at a therapeutic dose significantly display increased mitochondrial respiration in peripheral blood mononuclear cells (PBMCs), and platelets compared to untreated controls. Furthermore, the amount of superoxide is higher in mitochondria in PBMCs, and platelets from Simvastatin-treated patients than in untreated controls, and the abundance of mitochondrial superoxide, but not mitochondrial respiration trends with patient-reported myalgia. Ubiquinone (also known as coenzyme Q10) has been suggested as a potential treatment for SAM; however, an 8-week course of oral ubiquinone had no impact on mitochondrial functions or the abundance of superoxide in mitochondria from PBMCs, and platelets. These results demonstrate that long-term treatment with Simvastatin increases respiration and the production of superoxide in mitochondria of PBMCs and platelets.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Simvastatin improves mitochondrial respiration in peripheral blood cells

Durhuus

Hansson

Morville

et al. 2020

Sci Rep

Self Cite

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Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation‐Related Biomarkers: A GRADE‐Assessed Systematic Review and Updated Meta‐Analysis of Randomized Controlled Trials

Hou

Tian

Zhao

et al. 2023

Molecular Nutrition Food Res

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Scope: Coenzyme Q10 (CoQ10) has become a popular nutritional supplement due to its wide range of beneficial biological effects. Previous meta-analyses show that the attenuation of CoQ10 on inflammatory biomarkers remains controversial. This meta-analysis aims to assess the efficacy and optimal dose of CoQ10 supplementation on inflammatory indicators in the general population. Methods and results: Databases are searched up to December 2022 resulting in 6713 articles, of which 31 are retrieved for full-text assessment and included 1517 subjects. Double-blind randomized controlled trials (RCTs) of CoQ10 supplementation are eligible if they contain C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-𝜶 (TNF-𝜶). CoQ10 supplementation can significantly reduce the levels of circulating CRP (SMD: −0.40, 95% CI: [−0.67 to −0.13], p = 0.003), IL-6 (SMD: −0.67, 95% CI: [−1.01 to −0.33], p < 0.001), and TNF-𝜶 (SMD: −1.06, 95% CI: [−1.59 to −0.52], p < 0.001) and increase the concentration of circulating CoQ10. Conclusion: This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.

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Statin Therapy and Survival among Women with Ovarian Cancer: how much of it Is True?

Mormile

2019

Pathol. Oncol. Res.

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Inflammatory biomarkers in patients in Simvastatin treatment: No effect of co-enzyme Q10 supplementation

Cited by 16 publications

References 42 publications

Simvastatin improves mitochondrial respiration in peripheral blood cells

Simvastatin improves mitochondrial respiration in peripheral blood cells

Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation‐Related Biomarkers: A GRADE‐Assessed Systematic Review and Updated Meta‐Analysis of Randomized Controlled Trials

Statin Therapy and Survival among Women with Ovarian Cancer: how much of it Is True?

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