Inflammatory Profile of Older Adults in Response to Physical Activity and Diet Supplementation: A Systematic Review

Hernández-Lepe, Marco Antonio; Ortiz-Ortiz, Melinna; Hernández-Ontiveros, David Alfredo; Mejía-Rangel, Minerva Janini

doi:10.3390/ijerph20054111

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…Longer lifespan has been observed in simple model organisms as well as in mammals after its administration. Dietary supplementation associates with decreased level of inflammatory markers and increased insulin sensitivity [48]. The mechanism involves histone modification, DNA methylation and miRNA expression [49] mainly through modulation of SIRT1 activity [49].…”

Section: Substances Affecting the Epigenomementioning

confidence: 99%

The Nutriepigenome

Mirisola

2023

Genes

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Unlike genetic changes, epigenetics modulates gene expression without stable modification of the genome. Even though all cells, including sperm and egg, have an epigenome pattern, most of these modifications occur during lifetime and interestingly, some of them, are reversible. Lifestyle and especially nutrients as well as diet regimens are presently gaining importance due to their ability to affect the epigenome. On the other hand, since the epigenome profoundly affects gene expression profile it can be speculated that the epigenome could modulate individual response to nutrients. Recent years have thus seen growing interest on nutrients, macronutrients ratio and diet regimens capable to affect the epigenetic pattern. In fact, while genetic alterations are mostly detrimental at the individual level, reshaping the epigenome may be a feasible strategy to positively counteract the detrimental effect of aging. Here, I review nutrient consumption and diet regimens as a possible strategy to counteract aging-driven epigenome derangement.

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Section: Substances Affecting the Epigenomementioning

confidence: 99%

The Nutriepigenome

Mirisola

2023

Genes

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Plasminogen Activator Inhibitor‐1 in the Pathophysiology of Late Life Depression

Métivier,

Vivien,

Goy

et al. 2024

Int J Geriat Psychiatry

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IntroductionLate life depression (LLD) is characterized by specific clinical features including a high frequency of vascular form and frequent antidepressant treatment resistance. The expression and functions of the serine protease inhibitor, Plasminogen Activator Inhibitor‐1 (PAI‐1) is known to be altered by aging, vascular damage, insulin levels associated with a sedentary lifestyle, chronic stress leading to hypercortisolemia, and inflammatory changes linked to stress responses. These phenomena would be implicated in LLD like vascular depression. This article thus aims to review the existing literature regarding the association between LLD and plasmatic levels of PAI‐1, a marker of hypofibrinolysis. We hypothesize that increased age would be associated with changes in PAI‐1 plasma level and function which influence LLD pathogenesis and its treatment.ResultsAlthough a large number of studies on PAI‐1 changes in the elderly exist, studies about its implications in LLD are sparse. Despite heterogeneous findings regarding the direction of variation in plasmatic PAI‐1 levels among elderly participants with LLD, all studies demonstrated an association between PAI‐1 levels and current or remitted depressive symptoms. Moreover, disruptions in the concentrations of other biological markers influencing PAI‐1 expression, such as cytokines or adipokines, were also observed, notably an increase in the levels of interleukins 6 and 8.DiscussionLLD genesis appears to be influenced by PAI‐1 regulatory loops which are implicated in senescence or cell death. The resistance to antidepressant treatment appears to be linked to distinct biological profiles involving inflammatory and fibrinolytic factors. Taken together these data suggest that PAI‐1 pathway may be a promising target of treatment development efforts for LLD, and depression in general.

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The association between low skeletal muscle mass and immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus

Guo,

Pan,

Han

et al. 2024

Preprint

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Purpose To investigate the relationships between low skeletal muscle mass and immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM). Methods From April 2022 to May 2023, 978 middle-aged and elderly T2DM patients diagnosed in the Department of Endocrinology of the First Hospital of Lanzhou University were divided into a low skeletal muscle mass group and a normal group according to the muscle mass index, compared the differences between the groups. The above immunoinflammatory markers were grouped according to the quartile levels, and the prevalences of muscle mass loss were compared among the groups; the relationship between the immunoinflammatory index and low skeletal muscle mass in T2DM patients was analysed. Results Compared with the normal group, the levels of all immunoinflammatory indices of low skeletal muscle mass group were significantly increased ( P < 0.05); the prevalences of skeletal muscle mass loss were progressively raised with increasing quartile levels of each immunoinflammatory marker. The levels of immunoinflammatory markers were independently and positively correlated with the risk of low skeletal muscle mass (NAR: OR = 2.148, 95% CI 1.225–3.766, P = 0.008; NLR: OR = 1.210, 95% CI 1.036–1.411, P = 0.016; MLR: OR = 1.282, 95% CI 1.068–1.540, P = 0.008; SII: OR = 1.001, 95% CI 1.000 -1.002, P = 0.009; SIRI: OR = 1.828, 95% CI 1.271–2.628, P = 0.001; SIRI: OR = 1.003, 95% CI 1.001–1.004, P = 0.010) . Conclusions The occurrence of low skeletal muscle mass may be closely related to immune inflammation in middle-aged and elderly T2DM patients. Monitoring immune inflammation markers is of clinical value for early screening and intervention of muscle mass loss in middle-aged and elderly T2DM patients.

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Inflammatory Profile of Older Adults in Response to Physical Activity and Diet Supplementation: A Systematic Review

Cited by 4 publications

References 54 publications

The Nutriepigenome

The Nutriepigenome

Plasminogen Activator Inhibitor‐1 in the Pathophysiology of Late Life Depression

The association between low skeletal muscle mass and immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus

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