Influence of a family history of breast and/or ovarian cancer on breast cancer outcomes

Ay, Cao; He, Ming; Di, Gen-Hong; Wu, Jing; Js, Lu; Gy, Liu; Zz, Shen; Shao, Zhimin

doi:10.3892/etm.2011.275

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…A systematic review 4 published in 1999 summarized evidence on the association between family history of BC and BC prognosis and concluded that conflicting data existed, mostly due to small samples. Since then, studies with larger samples 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 have been conducted; however, these studies had mixed findings, with some reporting worse prognosis among those with a family history of BC, 5 , 6 , 7 some finding no significant difference, 8 , 9 , 10 , 11 , 12 and some reporting that family history had a protective benefit for prognosis. 13 , 14 , 15 Even less is known about whether the association differs across BC subtypes, such as ER-positive and ER-negative BC.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Breast Cancer Family History, Estrogen Receptor Status, and Breast Cancer Outcomes in Sweden

et al. 2023

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ImportanceBreast cancer (BC), the most prevalent cancer among women globally, is a heterogeneous disease, with prognosis differing by estrogen receptor (ER) status. Having a family history of BC increases the risk of BC; however, it is unclear whether family history is associated with the prognosis of overall and ER-specific BC.ObjectiveTo assess whether a family history of BC is associated with the prognosis of overall and ER-specific BC.Design, Setting, and ParticipantsThis cohort study was based on data from several national registers in Sweden. All female residents of Stockholm who were born after 1932; had their first BC diagnosis between January 1, 1991, and December 31, 2019; and had at least 1 identified female first-degree relative (FDR) were included. Women who were diagnosed with other types of cancer before their BC diagnosis, were older than 75 years at diagnosis, or had distant metastasis at diagnosis were excluded. A total of 28 649 women were included. Data were analyzed from January 10, 2022, to December 20, 2022.ExposuresFamily history of BC, defined as 1 or more female FDRs diagnosed with BC.Main Outcomes and MeasuresPatients were followed up until BC-specific death, censoring, or end of follow-up on December 31, 2019. The role of family history in BC-specific mortality was investigated using flexible parametric survival models among the full cohort, ER-positive subgroup, and ER-negative subgroup, adjusting for demographic characteristics, tumor characteristics, and treatments received.ResultsAmong 28 649 patients, the mean (SD) age at BC diagnosis was 55.7 (10.4) years; 19 545 (68.2%) had ER-positive BC, and 4078 (14.2%) had ER-negative BC. Overall, 5081 patients (17.7%) had at least 1 female FDR diagnosed with BC, while 384 (1.3%) had a family history of early-onset BC (FDR diagnosed before age 40 years). During the follow-up period (median [IQR], 8.7 [4.1-15.1] years), 2748 patients (9.6%) died of BC. Multivariable analyses revealed that having a family history of BC was associated with a lower risk of BC-specific death among the full cohort (hazard ratio [HR], 0.78; 95% CI, 0.65-0.95) and the ER-negative subgroup (HR, 0.57; 95% CI, 0.40-0.82) in the first 5 years, after which no association was observed. However, having an early-onset family history was associated with a higher risk of BC-specific death (HR, 1.41; 95% CI, 1.03-2.34).Conclusions and RelevanceIn this study, patients with a family history of BC did not necessarily have a worse prognosis. Those with ER-negative status and a family history of BC had more favorable outcomes in the first 5 years after diagnosis, possibly due to enhanced motivation to receive and adhere to treatment. However, patients with a family history of early-onset BC had worse survival, suggesting that genetic testing of newly diagnosed patients with early-onset family history may provide useful information to aid treatment and future research.

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Section: Introductionmentioning

confidence: 99%

Analysis of Breast Cancer Family History, Estrogen Receptor Status, and Breast Cancer Outcomes in Sweden

et al. 2023

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“…The participants of the current study were healthy people through the family history record of three types of tumor [4]. The current research goal was to identify coping styles that remain detrimental to subjective stress adaptation and to identify more good adaptation styles by exploring the association among cancer family history, coping style, and psychological pain that will offer respected data for psychological health meddling [5].…”

Section: Introductionmentioning

confidence: 99%

The Association among Cancer in Family History and Psychosocial Stress

Waheed¹,

Hussain²,

Khalid

et al. 2022

JPRI

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Aim: The purpose of this study is to look at the link among a family history of cancer, coping style, also emotional suffering. Methods: The self-reporting questionnaire, coping style scale, also effect of occasion scale-revised were also used to assess 85 individuals through the family history of cancer also 74 normal patients. Results: There have been substantial variations in nervousness, despair, cancer-exact distress, and psychological adjustment here between two groups of patients. Psychological discomfort (anxiety, sadness, and cancer-specific distress) was regarded as a negative coping style and the family history of cancer. In the family history and psychological discomfort, an undesirable coping style served as an intermediate. Conclusion: People through the family history of cancer are now extra probable to have a negative coping style, which predisposes them to more severe psychological discomfort.

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The association between prognosis of breast cancer and first-degree family history of breast or ovarian cancer: a systematic review and meta-analysis

2017

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Whether a positive family history of breast cancer or ovarian cancer (FHBOC) would affect the prognosis of breast cancer is still up for debate and further study. This meta-analysis was performed to clarify this issue. We reviewed two databases (PubMed and CNKI) for research articles published at any time from the inception of these databases to April 1, 2016 for articles detecting the impact of FHBOC on the prognosis of breast cancer. A meta-analysis was conducted to generated combined hazard ratios (HR) with 95% confidence intervals (CI) for overall survival (OS) and breast cancer-specific survival (BCSS). Eighteen studies were included in our qualitative analysis, with 15 studies ultimately part of the quantitative analysis. The pooled results demonstrated that a positive FHBOC was associated with better OS (0.89, 95% CI 0.83-0.95) and BCSS (0.90, 95% CI 0.82-0.99). In subgroup analyses, several subgroups (maximally adjusted studies, population based studies, high quality studies, family history of breast cancer, studies from Europe, studies from Asia, 1 affected relative, or tumor size > 2 cm), a positive first-degree FHBOC was associated with better prognosis of breast cancer. Notably, for those patients who underwent breast-conserving surgery, first-degree FHBOC was not a risk factor for OS (HR 1.08, 95% CI 0.53-2.21). Our meta-analysis demonstrated that a first-degree FHBOC was associated with better OS and BCSS in patients with breast cancer. These findings support that clinical management should not differ between women with and without FHBOC.

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Influence of a family history of breast and/or ovarian cancer on breast cancer outcomes

Cited by 7 publications

References 28 publications

Analysis of Breast Cancer Family History, Estrogen Receptor Status, and Breast Cancer Outcomes in Sweden

Analysis of Breast Cancer Family History, Estrogen Receptor Status, and Breast Cancer Outcomes in Sweden

The Association among Cancer in Family History and Psychosocial Stress

The association between prognosis of breast cancer and first-degree family history of breast or ovarian cancer: a systematic review and meta-analysis

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