Influence of a Sub-Therapeutic Level of Virginiamycin in Feed on the Incidence and Persistence of Salmonella typhimurium in Experimentally Infected Swine1

M, Abou-Youssef; DiCuollo, C. John; Miller, Cecil R.; Scott, George C.

doi:10.2527/jas1979.491128x

Cited by 9 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research regarding Salmonella shedding and antimicrobial resistance subsequent to antimicrobial therapy has been conducted in laboratory facilities involving experimental infection with S. enterica. 1,4,9,10,16,18,21,23,26,27,38,53,54 This may not represent the typical subclinical Salmonella infections on swine farms, which often involve multiple serovars and variable time and dose of Salmonella exposure. 20,29 There are limited observational investigations that evaluated the impact of antimicrobial use on the antimicrobial resistance profiles between farms.…”

Section: Subtherapeutic Chlortetracycline and Salmonellamentioning

confidence: 92%

The Effect of Subtherapeutic Chlortetracycline on Antimicrobial Resistance in the Fecal Flora of Swine

Funk

LeJeune

Wittum

et al. 2006

Microbial Drug Resistance

View full text Add to dashboard Cite

The aims of this research were to determine the association between inclusion of subtherapeutic chlortetracycline in the diets of swine and the prevalence and antimicrobial resistance of Salmonella; define the association between inclusion of subtherapeutic chlortetracycline and antimicrobial resistance in the aerobic Gram-negative fecal flora of swine; and estimate the proportion of total model variance attributable to farm, pig, and colony level effects. There was no association between subtherapeutic chlortetracycline exposure and Salmonella prevalence. There were increased odds for an aerobic Gram-negative fecal isolate to be resistant to ampicillin, ceftriaxone, and tetracycline if isolated from a pig that received chlortetracycline. There was a positive association between inclusion of subtherapeutic chlortetracycline in the diet and resistance to multiple antimicrobials. The proportion of total variance associated with farm, pig, and colony varied based on the resistance phenotype. Because farm-level variance contributed a small proportion to total variance in all models, effects of antimicrobial use interventions observed in this study may be predictive of anticipated impact of interventions on most swine farms. Resources for future investigations may be better allocated to sampling more pigs and more bacterial colonies per pig in relationship to the number of farms.

show abstract

Section: Subtherapeutic Chlortetracycline and Salmonellamentioning

confidence: 92%

The Effect of Subtherapeutic Chlortetracycline on Antimicrobial Resistance in the Fecal Flora of Swine

Funk

LeJeune

Wittum

et al. 2006

Microbial Drug Resistance

View full text Add to dashboard Cite

show abstract

“…Few on-farm clinical trials evaluating the effect of subtherapeutic antimicrobials on SE prevalence have been conducted. Previous research regarding SE shedding and antimicrobial resistance subsequent to antimicrobial therapy have been conducted in laboratory facilities involving experimental infection with S. enterica (Abou-Youssef et al, 1979;Baggesen et al, 1999;Dealy and Moeller, 1976;Delsol et al, 2003;Ebner and Mathew, 2000;Evangelisti et al, 1975;Girard et al, 1976;Gutzmann et al, 1976;Jacks et al, 1988;Jones et al, 1983;Mathew et al, 2002;Wilcock and Olander, 1978;Williams et al, 1978). The goal of this study is to determine the effect of stringent cleaning and the use of subtherapeutic CTC on the prevalence of SE in market ready swine.…”

mentioning

confidence: 99%

Effect of cleaning and subtherapeutic chlortetracycline on Salmonella

Mack

Bowman

Funk

2005

International Conference on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork

View full text Add to dashboard Cite

The objective of this study was to evaluate the effect of stringent cleaning and subtherapeutic chlortetracycline (CTC) on Salmonella enterica (SE) prevalence in market age swine. Twenty-four finisher barns from one farm were enrolled in a 2X2 factorial study design. Treatments included 1) assignment to a "stringent" or standard cleaning protocol and 2) inclusion of 50g of CTC/ton of feed or no feed antimicrobials. Barn swab samples were obtained pre-and post-cleaning for SE detection. Post-cleaning aerobic plate counts (APC) were collected. Feces were collected to determine SE prevalence pre-market. The stringent cleaning protocol resulted in decreased mean APC post-cleaning, but there was no difference in isolation of SE from the barn environment between cleaning protocols. Pigs housed in barns that received CTC had decreased odds of being SE positive, but there was no difference in the odds of a pig being SE positive between cleaning protocols.

show abstract

“…In an attempt to control the gut microbiota, antibiotic use has become a routine procedure for treating both humans [4] and livestock [5]. Studies have shown that antibiotic treatment of chickens, cattle and swine reduces Salmonella and E. coli infection [6,7,8,9,10]. However, antibiotics have been shown to increase Proteobacteria, a phylum which contains a large number of pathogenic bacteria [11,12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Prebiotic Properties of Galursan HF 7K on Mouse Gut Microbiota

Engevik

Faletti²,

Paulmichl³

et al. 2013

Cell Physiol Biochem

View full text Add to dashboard Cite

Background: With the rise of antibiotic resistance, new alternatives are being sought to effectively modulate the characteristics of gut microbiota to obtain pathogen resistance without the use of antibiotics. In the past, an oligosaccharide derivative of carrots, galursan HF 7K (GHF7K), has been used clinically in Austria and recently in the fowl-industry to promote health. This study examined the potential role of GHF7K as a prebiotic to alter the gut microbiota in mice. Methods: Mice were fed either a control diet (CT) or a diet containing 2% GHF7K in the water and chow for 2 weeks, and weight, food and water consumption, gut microbiota and ion composition of the intestinal fluid were examined. Results: Dietary supplement of GHF7K did not alter mouse weight or daily food consumption. Additionally, no changes were observed in the total number of luminal or mucosa-associated bacteria populations in GHF7K-fed mice. GHF7K supplementation significantly altered the composition of luminal, and to a less extent, mucosa-associated bacterial populations at the level of the phyla, with region-specific differences. Similar to antibiotic use, Proteobacteria number was increased in the ileum and colon of GHF7K-fed mice, with no changes in the number of beneficial Lactobacillus and Bifidobacterium genera of phylum Firmicutes. Corresponding with the altered gut microbiota, changes in the ion composition of the intestinal fluid were observed. An increased Cl^- concentration was observed in the duodenum and jejunum, while the Na⁺ concentration was increased in the cecum of GHF7K-fed mice. Decreases were observed in the K⁺ concentration in the cecum and distal colon. Conclusions: Dietary supplement of GHF7K is capable of altering the gut microbiota, which correlates to changes in the intestinal environment. These data suggest that GHF7K dietary supplement can purposefully be used to alter the gut microbiota, and thus could potentially represent an alternative approach to prophylactic antibiotic use.

show abstract

Influence of a Sub-Therapeutic Level of Virginiamycin in Feed on the Incidence and Persistence of Salmonella typhimurium in Experimentally Infected Swine1

Cited by 9 publications

References 3 publications

The Effect of Subtherapeutic Chlortetracycline on Antimicrobial Resistance in the Fecal Flora of Swine

The Effect of Subtherapeutic Chlortetracycline on Antimicrobial Resistance in the Fecal Flora of Swine

Effect of cleaning and subtherapeutic chlortetracycline on Salmonella

Prebiotic Properties of Galursan HF 7K on Mouse Gut Microbiota

Contact Info

Product

Resources

About