Influence of aging and menopause in determining vertebral and distal forearm bone loss in adult healthy women

Luisetto, Giovanni; Zangari, M.; Tizian, L.; Nardi, Alfredo; Ramazzina, Emilio; Adami, Silvano; Galuppo, Paolo

doi:10.1016/s0169-6009(08)80077-3

Cited by 30 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When ovarian oestrogen production declines during natural menopause, bone mineral density (BMD) decrease accelerates and fracture incidence increases [7]. Reports on the effect of early and surgical menopause on BMD and fracture incidence are inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Bone mineral density and fractures after risk-reducing salpingo-oophorectomy in women at increased risk for breast and ovarian cancer

Fakkert

Abma

Westrik

et al. 2015

European Journal of Cancer

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Bone mineral density and fractures after risk-reducing salpingo-oophorectomy in women at increased risk for breast and ovarian cancer

Fakkert

Abma

Westrik

et al. 2015

European Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Several studies have shown an age-related decrease in BMD in both men and women at different skeletal sites [3][4][5][6][7][8][9][10][11][12][13]; in women the decrease occurs predominantly after the menopause. Most of these studies dealing with the collection of normal values for bone density have only been concerned with either men or women, a specific age group, a specific site for BMD measurement or they have used a cross-sectional design.…”

Section: Introductionmentioning

confidence: 99%

Changes in Bone Mineral Density with Age in Men and Women: A Longitudinal Study

Warming

Hassager

Christiansen

2002

Osteoporosis International

317

180

View full text Add to dashboard Cite

We performed a prospective study to evaluate the normal changes in bone mineral density (BMD) in the forearm, hip, spine and total body, and to study the agreement between changes in BMD estimated from cross-sectional data and the actual longitudinal changes. Six hundred and twenty subjects (398 women, 222 men; age 20-89 years) without diseases or medication known to affect bone metabolism undertook baseline evaluations, and 525 (336 women, 189 men) completed the study. BMD was measured twice 2 years apart by dual-energy X-ray absorptiometry. From cross-sectional evaluations the only premenopausal bone loss (<0.003 g/cm2/year) was found in the hip. In women after menopause and in men an age-related bone loss (0.002-0.006 g/cm2/year) was found at all sites. The data from the longitudinal evaluation showed a small bone loss in women before menopause at the hip and lumbar spine (<0.4%/year (<0.004 g/cm2/year)); this bone loss nearly tripled in the early postmenopausal years (<10 years since menopause), and thereafter decreased to the premenopausal rate for the hip, and to zero for the lumbar spine. The most pronounced bone loss after menopause occurred in the forearm (1.2%/year (0.006 g/ cm2/year)), and it remained constant throughout life. In men there was a small longitudinal bone loss in the hip throughout life, and a small bone loss in the distal forearm after the age of 50 years. In all groups, except for the early postmenopausal women, we found a small increase in total body BMD with age. When comparing the changes in BMD estimated from cross-sectional data with the longitudinal changes, only the hip and forearm generally displayed agreement, whereas the changes in the total body and spine generally were incongruous. In conclusion, the hip and forearm appear to be the sites with the best agreement between the cross-sectional estimated and the longitudinal age-related changes in BMD.

show abstract

“…Quantitative assessment of bone mineral status at the forearm has been used to screen for osteoporosis [2,3], and study age-related changes [4][5][6], the impact of hormone replacement therapy [7,8], rheumatoid arthritis [9,10], renal osteodystrophy [11] and hyperparathyroidism [12,13]. The effects of exercise and different levels of activity have been investigated successfully [14,15].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Bone Mineral Assessment at the Forearm: A Review

Augat

Fuerst

Genant

1998

Osteoporosis International

105

View full text Add to dashboard Cite

Bone mineral density and geometric properties of the human forearm can be measured to determine the amount of bone or bone loss at the scanning site and to predict the risk of forearm fractures. These forearm measurements are also used to estimate bone mass at remote anatomical locations and thereby estimate the risk for spine, hip and other fractures. The peripheral location of the human forearm, with its relatively small amount of surrounding soft tissue, improves the accuracy and the precision of bone mass measurement and has made this site an early choice for the assessment of a subject's bone mineral status. Furthermore, the anatomy of the human radius enables the examination of both cortical and cancellous bone. This review describes the procedures for non-invasive bone assessment at peripheral sites including some of the more recently developed systems dedicated to assessment of the distal radius. The accuracy, precision and normative values they provide are presented. Responses to different forms of therapies as well as the ability to discriminate or predict osteoporotic fractures are also assessed. Low radiation dose, comfortable and fast handling, moderate cost, and a strong association with the risk of non-spine fractures, promote the use of forearm scanning as a widely applied screening procedure for the detection of generalised osteoporotic bone loss. However, a higher accuracy of fracture risk prediction at the spine or at the hip can be achieved by a direct bone density measurement at these sites. The monitoring of treatment at the distal forearm appears to require a longer follow-up time due to its decreased responsiveness compared with such highly trabecular load-bearing sites as the spine and the proximal femur.

show abstract

Influence of aging and menopause in determining vertebral and distal forearm bone loss in adult healthy women

Cited by 30 publications

References 36 publications

Bone mineral density and fractures after risk-reducing salpingo-oophorectomy in women at increased risk for breast and ovarian cancer

Bone mineral density and fractures after risk-reducing salpingo-oophorectomy in women at increased risk for breast and ovarian cancer

Changes in Bone Mineral Density with Age in Men and Women: A Longitudinal Study

Quantitative Bone Mineral Assessment at the Forearm: A Review

Contact Info

Product

Resources

About