Influence of blend ratio and mangosteen extract in chitosan/collagen gels and scaffolds: Rheological and release studies

Milan, Eduardo P.; Martins, Virgínia da Conceição Amaro; Horn, Marilia M.; Plepis, Ana Maria de Guzzi

doi:10.1016/j.carbpol.2022.119647

Cited by 12 publications

(6 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Higuchi equation is possibly the first model that quantifies drug release from thin films. Due to its simplicity [ 14 ], the Higuchi equation is widely used to correlate the kinetic of drugs released from various solid systems [ 8 , 15 , 16 , 17 , 18 , 19 , 20 ]. Th Higuchi equation has the following for:

where n t is the cumulative amount of the drug released at time t , while n max is the maximum amount of drug that can be released at an infinite time.…”

Section: Resultsmentioning

confidence: 99%

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

et al. 2022

View full text Add to dashboard Cite

In this study, CNCs were extracted from durian rind. Modification to CNCs with saponin was conducted at 50 °C for one h. CNCs and CNCs-saponin were employed as dexamethasone carriers. Modification to CNCs using saponin did not change the relative crystallinity of CNCs. CNCs’ molecular structure and surface chemistry did not alter significantly after modification. Both nanoparticles have surface charges independently of pH. Dexamethasone-released kinetics were studied at two different pH (7.4 and 5.8). Higuchi, Ritger–Peppas, first-order kinetic and sigmoidal equations were used to represent the released kinetic data. The sigmoidal equation was found to be superior to other models. The CNCs and CNCs-saponin showed burst release at 30 min. The study indicated that cell viability decreased by 30% after modification with saponin.

show abstract

where n t is the cumulative amount of the drug released at time t , while n max is the maximum amount of drug that can be released at an infinite time.…”

Section: Resultsmentioning

confidence: 99%

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The ability for hydrogels to expand is substantially influenced by the presence of hydrophilic -OH groups, the degree of crosslinking, and crystallinity. [26] After 50 h of incubation, the swelling efficiencies of the GelMA-G and GelMA-Y composite hydrogels were much greater than those of the pure GelMA scaffold (≈218%). The larger pores and numerous phenolic -OH groups of the polyphenolic CQDs in the GelMA-CQD composite hydrogels, which encouraged the formation of hydrogen bonds between the CQDs and GelMA scaffold, were attributed to the GelMA-CQD composite hydrogels' superior swelling potential compared to that of the pure GelMA.…”

Section: Physicochemical Properties Of the Hydrogel Inksmentioning

confidence: 91%

“…It is well-known that a value of n <0.49 indicates the Fickian type diffusion and n > 0.49 correspond to the anomalous or non-Fickian type diffusion. [26,35] Thus, both the samples (pH 6.5 and 7.4) after NIR irradiation exhibited the non-Fickian type diffusion, where the CQDs-embedded GelMA matrix controlled the release of the Dox via phototherapy. The hyperthermia effect induced the GelMA matrix to shrink and release the drug molecule in the PBS buffer.…”

Section: In Vitro Drug Delivery and Nir-triggered Antiosteosarcoma Th...mentioning

confidence: 95%

“…To gain an insight about the diffusion kinetics, various mathematical models have been employed to understand the effect of nanofiller on drug diffusion. [26] In this study, we used Higuchi and Korsmeyer-Peppas model to fit the experimental data. For a certain amount of drug (Q) released in specific time (t), the release kinetics can be explained by following equations:…”

Section: In Vitro Drug Delivery and Nir-triggered Antiosteosarcoma Th...mentioning

confidence: 99%

See 1 more Smart Citation

A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation

Dutta

Ganguly

Hexiu

et al. 2023

Macromolecular Bioscience

View full text Add to dashboard Cite

One of the significant challenges in bone tissue engineering (BTE) is the healing of traumatic tissue defects owing to the recruitment of local infection and delayed angiogenesis. Herein, a 3D printable multi‐functional hydrogel composing polyphenolic carbon quantum dots (CQDs, 100 µg mL−1) and gelatin methacryloyl (GelMA, 12 wt%) is reported for robust angiogenesis, bone regeneration and anti‐tumor therapy. The CQDs are synthesized from a plant‐inspired bioactive molecule, 1, 3, 5‐trihydroxybenzene. The 3D printed GelMA‐CQDs hydrogels display typical shear‐thinning behavior with excellent printability. The fabricated hydrogel displayed M2 polarization of macrophage (Raw 264.7) cells via enhancing anti‐inflammatory genes (e.g., IL‐4 and IL10), and induced angiogenesis and osteogenesis of human bone mesenchymal stem cells (hBMSCs). The bioprinted hBMSCs are able to produce vessel‐like structures after 14 d of incubation. Furthermore, the 3D printed hydrogel scaffolds also show remarkable near infra‐red (NIR) responsive properties under 808 nm NIR light (1.0 W cm−2) irradiation with controlled release of antitumor drugs (≈49%) at pH 6.5, and thereby killing the osteosarcoma cells. Therefore, it is anticipated that the tissue regeneration and healing ability with therapeutic potential of the GelMA‐CQDs scaffolds may provide a promising alternative for traumatic tissue regeneration via augmenting angiogenesis and accelerated immunomodulation.

show abstract

“…The unique viscoelastic properties of collagen facilitate its use in tissue engineering and drug delivery applications, such as injectable biomaterials and wound dressings [43][44][45]. The complex viscosity of the pH-treated collagen solutions decreased with increasing sweep frequency (Figure 8c), suggesting that all pH-treated collagen solutions exhibited non-Newtonian shear thinning behaviour, which is generally suitable for practical applications, such as those requiring syringeability and easy spreadability [46]. With an increase in pH from 2 to 10, the G′ and G″ of the collagen solution at 0.01 Hz increased from 0.0124 and 982 to 0.493 and 1260 Pa at 10 Hz (Figure 8a,b).…”

Section: Rheological Propertiesmentioning

confidence: 99%

Effect of pH on the Structure, Functional Properties and Rheological Properties of Collagen from Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) Skin

Wu,

Li,

Chen

2024

Marine Drugs

View full text Add to dashboard Cite

Collagen is an important biopolymer widely used in food, cosmetics and biomedical applications. Understanding the effect of pH on the structure and properties of collagen is beneficial for its further processing and exploitation. In this study, greenfin horse-faced filefish skin collagen (GHSC) was prepared and identified as a type I collagen. We systematically investigated the effect of pH on the structural, functional and rheological properties of GHSC. Scanning electron microscopy showed that the collagen morphology changed from an ordered stacked sheet structure to a rough silk-like structure as pH increased. Gaussian-fitted Fourier infrared spectroscopy results of the collagen revealed that it unfolded with increasing pH. Moreover, the ordered structure was reduced, and random coils became the dominant conformation. Its β-sheet and random coil contents increased from 18.43 ± 0.08 and 33.62 ± 0.17 to 19.72 ± 0.02 and 39.53 ± 1.03%, respectively, with increasing pH. α-helices and β-turns decreased from 35.00 ± 0.26 and 12.95 ± 0.01 to 29.39 ± 0.92 and 11.36 ± 0.10%, respectively. The increase in β-sheets and random coils allowed the pI-treated collagen to exhibit maximum water contact angle. The emulsification and foaming properties decreased and then increased with increasing pH in a V-shape. The increased net surface charge and β-sheets in collagen benefited its emulsification and foaming properties. The rheological results showed that the protoprotein exhibited shear-thinning properties in all pH ranges. The collagen solutions showed liquid-like behaviour in low-pH (2, 4) solutions and solid-like behaviour in high-pH (6, 7.83 and 10) solutions. Moreover, the frequency-dependent properties of the storage modulus (G′) and loss modulus (G″) of the collagen solutions weakened with increasing pH. Collagen has considerable frequency-dependent properties of G′ and G″ at low pH (2, 4). Thus, the importance of collagen raw material preparation for subsequent processing was emphasised, which may provide new insights into applying collagen-based materials in food, biomaterials and tissue engineering.

show abstract

Influence of blend ratio and mangosteen extract in chitosan/collagen gels and scaffolds: Rheological and release studies

Cited by 12 publications

References 44 publications

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation

Effect of pH on the Structure, Functional Properties and Rheological Properties of Collagen from Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) Skin

Contact Info

Product

Resources

About