Influence of chemical composition of soils on the galanthamine content in<i>Levcojum aestivum</i>

Gorinova, N.; Atanassov, A.; Stojanov, Dijana; Tencheva, Jasmina

doi:10.1080/01904169309364638

Cited by 21 publications

(14 citation statements)

References 2 publications

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“…1). The higher concentration of alkaloids in leaves than in bulbs was in agreement with results observed in other amaryllidaceous plants, like Leucojum aestivum [9] and N. assoanus [7].…”

supporting

confidence: 90%

Galanthamine Pattern inNarcissus confususPlants

López

Viladomat²,

Codina³

2003

Planta med

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Galanthamine is an Amaryllidaceae-type alkaloid with acetylcholinesterase inhibitory activity which is used in the treatment of Alzheimer's disease. The distribution of galanthamine and four other alkaloids in different organs of Narcissus confusus plants, as well as the variations occurring during the ontogenic cycle of this plant species, was studied. The five alkaloids were found to be present in all the organs at every stage, with the exception of haemanthamine in senescent flowers. The highest amount of alkaloids occurred in the bulb at the emerging stage, galanthamine being the most abundant, reaching a concentration of up to 2.5 % referred to dry weight.

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“…1). The higher concentration of alkaloids in leaves than in bulbs was in agreement with results observed in other amaryllidaceous plants, like Leucojum aestivum [9] and N. assoanus [7].…”

supporting

confidence: 90%

Galanthamine Pattern inNarcissus confususPlants

López

Viladomat²,

Codina³

2003

Planta med

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“…Earlier reports showed that the concentration of alkaloids vary in great amount in different Amaryllidaceae plants with the seasonal growth (Katoch et al, 2012;Tram et al, 2002). In addition, it has been documented that a relationship existed between the alkaloid content of an Amaryllidaceous species Leucojum aestivum L. and the chemical composition of the soil (Gorinova et al, 1993). Therefore, the variations of the alkaloid content in G. elwesii specimens may be influenced by several factors including polymorphism, collection site and time.…”

Section: Resultsmentioning

confidence: 99%

Application of HPLC-DAD for the quantification of Lycorine in Galanthus elwesii Hook

Emir

Bozkurt

et al. 2017

Braz. J. Pharm. Sci.

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In the present study, a reversed-phase high-performance liquid chromatographic method has been used for the quantitative determination of lycorine in the aerial parts and bulbs of G. elwesii Hook. A simple method for the extraction of lycorine in low mass plant samples was employed utilizing pre-packed columns with diatomaceous earth (Extrelut®). The chromatographic separation was performed using an isocratic system with a mobile phase of trifluoroacetic acid-water-acetonitrile (0.01:92.5:7.5, v/v/v) applied at a flow rate 1 mL min -1 using diode array detector. The content of lycorine in the bulbs and aerial parts of G. elwesii collected from Demirci (Manisa) was found as 0.130 and 0.162 %, respectively. Additionally, in the bulbs of the specimens collected from Sogucak (Balikesir), lycorine was quantified as 0.055 %, whereas in the aerial parts, it was determined as 0.006 %. The method was validated partially with respect to system specificity, linearity, accuracy, precision, limits of detection (LOD) and quantitation (LOQ). Validation procedures displayed that the method was specific, accurate and precise.Uniterms: Alkaloids. Amaryllidaceae. Plant extracts. High Performance Liquid Chromatography/method validation. High Perfomance Liquid Chromatography/quantitative analysis.

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“…The most widely used method for the investigation of Amaryllidaceae alkaloids in plants and in their in vitro cultures is HPLC. This method is very useful for the routine analysis of one or several alkaloids (Gorinova et al, 1993;Sellés et al, 1997;López et al, 2002); however, the spectrophotometric detectors usually employed, namely UV, photodiode-array etc., provide limited information about the structure of the compounds present. Since MS detectors, which could assist with structural determination, are still rarely used in HPLC analysis, the use of previously isolated standards is often essential.…”

Section: Introductionmentioning

confidence: 99%

CGC-MS of alkaloids inLeucojum aestivum plants and theirin vitro cultures

et al. 2005

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Underivatised alkaloid mixtures extracted from intact plants and in vitro cultures of Leucojum aestivum (Amaryllidaceae) were investigated by capillary GC-MS. Excellent peak resolution for the alkaloids was exhibited and isomers of galanthamine and N-formylnorgalanthamine were well separated. Fourteen alkaloids of galanthamine, lycorine and crinane types were identified, 11 in the intact plants and eight in the in vitro cultures.

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Influence of chemical composition of soils on the galanthamine content inLevcojum aestivum

Cited by 21 publications

References 2 publications

Galanthamine Pattern inNarcissus confususPlants

Galanthamine Pattern inNarcissus confususPlants

Application of HPLC-DAD for the quantification of Lycorine in Galanthus elwesii Hook

CGC-MS of alkaloids inLeucojum aestivum plants and theirin vitro cultures

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