Influence of choroidal thickness on subfoveal choroidal thickness measurement repeatability using enhanced depth imaging optical coherence tomography

Cho, A R; Choi, Yoomi; Kim, Y T

doi:10.1038/eye.2014.197

Cited by 26 publications

(28 citation statements)

References 26 publications

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“…In addition, eyes with subretinal fluid tend to have thicker choroids, though this relationship was not significant in our cohort. Consistent with prior studies, we also found that a thicker choroid reduces measurement repeatability, 14,15,19 so we cannot exclude the possibility that CT may exert a stronger influence on measurement precision, especially since retinal thickness did not appear to have an effect. We also cannot exclude the potential effect of other OCT features such as intraretinal hyperreflective foci or subretinal hyperreflective material which may warrant future research.…”

Section: Discussionsupporting

confidence: 80%

“…The deeper location of the choroid inherently limits its visibility, and a thicker choroid reduces measurement reliability. 14,15 Finally, there is also variability in how the posterior boundary of the choroid is defined, which may include the border of the vessel lumena, the choroid stroma, or the sclera, and particularly when the suprachoroidal layer is visible. Recent studies suggest that the repeatability of CT measurements may be optimized at the stromal border.…”

Section: Introductionmentioning

confidence: 99%

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Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Wong

Vuong

Cunefare

et al. 2017

American Journal of Ophthalmology

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Purpose To determine if different types of retinal fluid in the central macula affect the reproducibility of choroidal thickness (CT) measurements on enhanced depth imaging optical coherence tomography (EDI-OCT) Design retrospective, reliability analysis Methods EDI-OCT images were obtained and the choroidal-scleral junction was analyzed through semi-automated segmentation. CT was measured at the fovea and averaged across the central 3 mm horizontal segment. Demographic data, central macular thickness and type of fluid present were recorded. Intragrader and intergrader repeatability were assessed using the intraclass correlation coefficient (ICC) and coefficient of repeatability (CR). Results Of 124 eyes analyzed, 60 (48.4%) had diabetic macular edema, 32 (25.8%) had neovascular age-related macular degeneration, and 32 (25.8%) had other causes of fluid. Intergrader ICC (CR) were 0.95 (74.1 μm) and 0.96 (63.9 μm) for subfoveal and average CT, respectively. CR were similar across various causes of retinal fluid, but were worst for subretinal fluid compared to intraretinal or sub-retinal pigment epithelial fluid. CR also worsened with increasing choroidal thickness, but was not affected by retinal thickness. Intragrader repeatability was generally greater than intergrader values, and followed the same trend. Conclusions The presence of macular fluid reduces CT measurement reproducibility, particularly in eyes with subretinal fluid and greater choroidal thickness. A difference of 74.1 μm in subfoveal CT or 63.9 μm in average CT may be necessary to detect true clinical change in eyes with macular fluid.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Wong

Vuong

Cunefare

et al. 2017

American Journal of Ophthalmology

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“…Several authors have reported that EDI-OCT images are not as clear in patients with a thickened choroid [12, 21]. Specifically, it is more difficult to discern the distal boundary of the choroid at the choroid-sclera junction when the choroid is thickened [12].…”

Section: Discussionmentioning

confidence: 99%

Elevated Choroidal Thickness and Central Serous Chorioretinopathy in the Fellow Eyes of Patients with Circumscribed Choroidal Hemangioma

et al. 2018

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Objective: To determine whether increased choroidal thickness (CT) is associated with circumscribed choroidal hemangioma (CCH) and whether patients with CCH are predisposed to central serous chorioretinopathy (CSCR). Methods: We performed a retrospective consecutive observational study of 15 fellow eyes of 15 patients who had CCH. A- and B-scan ultrasonography, fluorescein angiography (FA), and optical coherence tomography (OCT) findings were reviewed to confirm the diagnosis of CCH. Fellow eye CT was measured using enhanced depth imaging OCT. FA, indocyanine green angiography, and OCT images of fellow eyes were reviewed for signs of CSCR. Results: Mean subfoveal CT was significantly greater in the fellow eyes of patients with CCH than in age-matched normal eyes (p = 0.004). Three of 15 (20.0%) fellow eyes of CCH patients had retinal pigment epithelium disruptions and/or pigment epithelial detachments indicative of previous asymptomatic CSCR. Conclusion: In this pilot study, elevated CT was associated with a risk of developing CCH as well as CSCR in patients of varying ages. Patients diagnosed with CCH should be screened for CSCR in the fellow eye. Further exploration of this association may reveal useful clues about the biology of abnormally elevated choroidal hyperpermeability and its various clinical manifestations.

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“…7 Two SFCT measurements from a horizontal scan and a vertical scan were averaged, and those averaged values were used for statistical analysis. 8 The 6-mm macular map was used to evaluate the central subfield retinal thickness in 1 mm of macular map.…”

Section: Methodsmentioning

confidence: 99%

Comparison of subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia

Kim

Park

Kim

et al. 2015

Eye

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Purpose Pregnancy is a known predisposing factor for central serous chorioretinopathy (CSC). Choroidal thickness (CT) increases in patients with CSC. This study was designed to evaluate CT in pregnant women. Patients and methods This was a prospective study. Fourteen healthy pregnant women and seven patients with pre-eclampsia were included. Twenty-one normal subjects were also recruited. CT was measured using enhanced-depth imaging optical coherence tomography.Results The mean CT of normal subjects, healthy pregnant women and patients with pre-eclampsia were 264.95 ± 21.03, 274.23 ± 29.30 and 389.79 ± 25.13 μm, respectively (normal subjects vs healthy gravidas: P40.05; normal subjects vs pre-eclampsia: Po0.001; healthy gravidas vs pre-eclampsia: Po0.001). CT decreased from 381.05 ± 22.96 μm to 335.17 ± 9.97 μm 1 week after delivery in patients with pre-eclampsia. Conclusions Pregnancy itself did not increase CT, whereas pre-eclampsia did appear to result in increased CT. This suggests that additional unknown factors induce hyperpermeability in pregnant women.

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Influence of choroidal thickness on subfoveal choroidal thickness measurement repeatability using enhanced depth imaging optical coherence tomography

Cited by 26 publications

References 26 publications

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography

Elevated Choroidal Thickness and Central Serous Chorioretinopathy in the Fellow Eyes of Patients with Circumscribed Choroidal Hemangioma

Comparison of subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia

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