Influence of dl-thyroxine and cortisone on femurs of rats with odoratism

Gabay, Sabit; Vivanco, F. Hernandez; Ramos, F.; Diaz, C.Jimenez

doi:10.1016/0003-9861(61)90222-3

Cited by 11 publications

(3 citation statements)

References 13 publications

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“…Neither was there any definite effect of thyroxine on the total hydroxyproline in mouse skin, although the hydroxyproline content was significantly higher in the skin of thyrotrophin-treated dwarf mice than in thyroxine-treated dwarf mice (DYR-BYE et al 1959). Also in the experiments of GABAY et al (1961) thyroxine had no effect on the total hydroxyproline content of bones in normal animals, although thyroxine inhibited the increase in hydroxyproline of bones caused by methylene aminoacetonitrile. O n the other hand, the investigations of MOLTKE (1958) indicate that thyroxine has a definite inhibitory effect on the tensile strength of healing wounds.…”

Section: Discussionmentioning

confidence: 84%

Effect of Thyroxine on the Hydroxyproline in Rat Urine and Skin

Kivirikko

Koivusalo

Laitinen

et al. 1963

Acta Physiologica Scandinavica

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The effect of L‐thyroxine on the metabolism of collagen in rats was studied by analyzing the urine for free and total hydroxyproline. In addition the hydroxyproline of the neutral salt and citrate soluble fractions of the skin was determined. Both free and total hydroxyproline were equally increased in the urine after the administration of L‐thyroxine. The increase was of the same magnitude in two, four and twelve months old rats, although the basal excretion values of hydroxyproline were significantly lower in the older rats. The content of hydroxyproline in both neutral salt and citrate soluble fractions of the skin was slightly decreased after the administration of L‐thyroxine.

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Section: Discussionmentioning

confidence: 84%

Effect of Thyroxine on the Hydroxyproline in Rat Urine and Skin

Kivirikko

Koivusalo

Laitinen

et al. 1963

Acta Physiologica Scandinavica

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“…The toxic effects of the structurally similar 0-aminopropionitrile (BAPN; Schilling and Strong, 1954) and methyleneaminoacetonitrile (MAAN;Gabay et al, 1961) produce gross skeletal deformities with connective tissue abnormalities in experimental animals (osteolathyrism). A closely related synthetic iminonitrile, p,P'-iminodipropionitrile (IDPN), elicits a permanent hyperkinetic syndrome (neurolathryism) in mice (Delay et al, 1952;Thuillier et al, 1953) and in rats (Hartmann and Stich, 1957;Selye, 1957).…”

Section: Introductionmentioning

confidence: 99%

Regional neurochemical studies on the effect of β,β′ ‐iminodipropionitrile (IDPN) in the rat

Langlais

Huang

Gabay

1975

J of Neuroscience Research

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A permanent hyperkinetic syndrome, characterized by excitation, choreiform head and neck movements and circling, which has led to it being called collectively the "ECC-syndrome," is induced in rats by the daily IP administration of beta, beta'-iminodipropionitrile (IDPN), 300 mg/kg, for 7 days. The levels of the biogenic amines, norepinephrine (NE), dopamine (DA), serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), were measured in the striatum, midbrain, medulla, cortex, and cerebellum on the day the syndrome appeared (day 7) and one week later (day 14). The biogenic amine most affected by IDPN administration was 5-HT. On day 7, striatal 5-HT levels increased and 5-HIAA levels decreased while in the medulla and midbrain, 5-HIAA levels increased. On day 14, significant reductions in both 5-HT, in the midbrain, striatum, and cortex, and 5-HIAA, in all regions except the cortex, were observed. NE was markedly increased in the medulla, midbrain, and striatum on day 7, whereas on day 14 it was found to be within the normal range in these same regions. With the exception of a slight, but significant, increase in the cortex on day 7, DA levels in all regions were found to be relatively unaffected by IDPN administration on both day 7 and day 14. In an attempt to detect degenerative changes which might be taking place in the brain and which might provide an explanation for the permanency of the behavioral disturbances, the uptake of [3H]-labeled NE, DA, and 5-HT into synaptosomal-rich preparations of striatum and the uptake of NE and 5-HT into the midbrain area were compared between normal and syndromized rats on both day 7 and day 14. Small changes were observed but they were not statistically significant. The alterations of 5-HT and 5-HIAA levels in several regions of the brain under the conditions examined may indicate that IDPN's neurotoxicity primarily affects 5-HT-containing neurones. The active membrane transporting system of the nerve endings studied, however, remained relatively intact. This latter finding eliminates the possibility that neuronal degeneration in these areas is responsible for the decreased 5-HT and 5-HIAA levels or is the pathology underlying the permanency of the syndrome. These results are evaluated in terms of a possible model for hyperkinetic disorders.

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“…This callus exhibits some of the chemical features of other lathyritic tissue, in that the soluble collagen is increased (8) though total collagen is not, and hexosamine values are depressed as in the epiphysis (65). No reason for the increase in volume of this tissue has been reported; however, Gabay and coworkers (66) and Smith (67) describe an increase in the amount of mucopolysaccharide in the skeleton of lathyritic rats, which may be another manifestation of this same effect.…”

Section: Effects Of Lathyrogenic Agents On the Polysaccharides Of Conmentioning

confidence: 98%

Experimental Lathyrism: Apparent Antithesis of Aging in Connective Tissue

Bickley

1964

J American Geriatrics Society

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Influence of dl-thyroxine and cortisone on femurs of rats with odoratism

Cited by 11 publications

References 13 publications

Effect of Thyroxine on the Hydroxyproline in Rat Urine and Skin

Effect of Thyroxine on the Hydroxyproline in Rat Urine and Skin

Regional neurochemical studies on the effect of β,β′ ‐iminodipropionitrile (IDPN) in the rat

Experimental Lathyrism: Apparent Antithesis of Aging in Connective Tissue

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