Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans

Lee, Kwang-Jae; Vos, Rita De; Janssens, Jozef; Tack, Jan

doi:10.1152/ajpgi.00086.2003

Cited by 122 publications

(116 citation statements)

References 31 publications

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“…Ulcer-and dysmotility-type symptoms are seen in a certain number of patients, and the mechanism of interaction with acid has been studied. As Lee et al reported, increased gastric sensitivity to gastric distension due to duodenal acid exposure might cause the symptoms [19].…”

Section: Discussionmentioning

confidence: 96%

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Adachi

Matsumori

Fujisawa

et al. 2006

J. Clin. Biochem. Nutr.

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Summary Objective: A number of clinical trials have reported that proton-pump inhibitors are efficacious in the treatment of upper abdominal symptoms, but most of these trials have been carried out in Caucasians. This study investigated the type of upper abdominal symptoms reported by Japanese patients with reflux esophagitis and the efficacy of omeprazole for treating their symptoms.Methods: A total of 234 patients aged ≥20 years with grade A to D reflux esophagitis were enrolled in this multicenter, open study. Patients received omeprazole 10 or 20 mg/day for 4 weeks. Symptom and quality of life questionnaires were administered at baseline, week 2 and week 4.Results: Among the 221 evaluable patients, almost 70% reported reflux-type symptoms (e.g. regurgitation and heartburn). Ulcer-and dysmotility-type symptoms (e.g. stomach pain and belching) were also common, occurring in 38-62% of patients. After 4 weeks of omeprazole *To whom correspondence should be addressed. Tel: +81-853-20-2190 Fax: +81-853-20-2187 E-mail: kadachi@med.shimane-u.ac.jp Abbreviations: ARD, acid-related disease; FD, functional dyspepsia; GSRS, Gastrointestinal Symptoms Rating Scale; PPIs, proton pump inhibitors; PU, peptic ulcer; QOL,quality of life; RE, reflux esophagitis; SD, standard deviation. Conclusion: Reflux-type symptoms as well as ulcer-and dysmotility-type symptoms were seen frequently in Japanese patients with reflux esophagitis. However, omeprazole improved all symptom types and quality of life in this patient population.

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Section: Discussionmentioning

confidence: 96%

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Adachi

Matsumori

Fujisawa

et al. 2006

J. Clin. Biochem. Nutr.

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“…4,35,36 In addition, Kusano et al 6 reported that early phase of gastric emptying is also contributed to FD patients as well as delayed gastric emptying. 31 Lee et al 30 reported that gastric flow into the duodenum including gastric acid inhibits gastric accommodation to a meal and contributes to postprandial symptom. Considering these reports, it warrants further exploration to clarify the precise mechanisms underlying impaired gastric emptying in early postprandial phase to truly understand the pathophysiology of FD.…”

Section: Discussionmentioning

confidence: 99%

Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan

Yanagawa

Futagami

Shimpuku

et al. 2015

J Neurogastroenterol Motil

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Background/Aims There are no available data about the relationship between ghrelin gene genotypes and early phase of gastric emptying in functional dyspepsia (FD) as defined by Rome III classification. Methods We enrolled 74 patients presenting with typical symptoms of FD and 64 healthy volunteers. Gastric motility was evaluated using the 13 C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms and self-rating questionnaires for depression (SRQ-D) scores to determine status of depression. The Arg51Gln (346G>A), preproghrelin (3056T>C), Leu72Met (408C>A), Gln90Leu (3412T>A) and G-protein β3 (825C>T) polymorphisms were analyzed in the DNA from blood samples of enrolled subjects. Genotyping was performed by polymerase chain reaction. Results There was a significant relationship between the Gln90Leu3412 genotype and SRQ-D score in FD patients ( P = 0.009). Area under the curve at 15 minutes (AUC 15 ) value was significantly associated with the Leu72Met408 genotype ( P = 0.015) but not with entire gastric emptying. Conclusions The Leu72Met (408C>A) single nucleotide polymorphism was significantly associated with early phase of gastric emptying in FD patients. Further studies will be necessary to clarify the association between ghrelin gene single nucleotide polymorphisms and early phase of gastric emptying in FD patients.

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“…Hence, the use of the barostat is the standard method for the assessment of AR in the proximal stomach and has been used in several studies (4,25,(30)(31)(32)(33). However, this method is invasive and because the presence of food in the stomach would interfere with the expansion of the balloon of the barostat system, the value of the postprandial gastric volume may be less than that recorded before consuming the test meal (34).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Rikkunshito, a Traditional Japanese Medicine (Kampo), in Treating Functional Dyspepsia

et al. 2010

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Background Rikkunshito, a traditional Japanese (Kampo) medicine, is widely prescribed as an oral preparation for the treatment of functional dyspepsia (FD). In our previous study, we reported that extracorporeal ultrasonography (US) is a useful technique for the assessment of the gastric accommodation reflex (AR) and duodenogastric motility. In this study, we examined the effects of Rikkunshito on the gastroduodenal function in patients with FD. Methods Sixteen FD patients (median age, 45 y) underwent US, before and after 14 days of treatment with Rikkunshito (7.5 g b.d.). For assessment of the AR, a cross-sectional area of the proximal stomach was measured after incremental ingestion of a liquid meal up to 400-mL. The expansion rate was used as the parameter to determine the AR. Then, the gastric emptying rate (GER), motility index (MI), and reflux index (RI) were evaluated using previously reported methods. Results Although no significant changes were observed in the total score of the Gastrointestinal Symptom Rating Scale (GSRS), the scores of 3 of the 15 symptoms of GSRS decreased significantly after treatment with Rikkunshito. The expansion rate of the proximal stomach was significantly greater after treatment with Rikkunshito than before the treatment. Although the GER and MI increased significantly, no significant differences in the RI were observed after treatment with Rikkunshito. Conclusion These observations suggested that Rikkunshito may be beneficial for the treatment of FD patients with impaired AR and gastric motility. These results also suggested that Rikkunshito has a therapeutic potential for FD and GERD.

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Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans

Abstract: Lee, Kwang-Jae, Rita Vos, Jozef Janssens, and Jan Tack. Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans.

Cited by 122 publications

References 31 publications

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan

Efficacy of Rikkunshito, a Traditional Japanese Medicine (Kampo), in Treating Functional Dyspepsia

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