Gravity waves (GWs) exist in atmospheres of all planets with convectively stable stratification. They transport energy and momentum from denser tropospheres to thinner upper levels (Yiğit & Medvedev, 2019). Effects produced by GWs are particularly strong in the middle and upper atmospheres of Earth and Mars (see recent reviews of Medvedev & Yiğit, 2019; Yiğit & Medvedev, 2015, correspondingly), thus making them a major dynamical mechanism that couples the lower and upper atmospheres on both planets. Being relatively small in size (from tens to hundreds of kilometers in horizontal wavelength) and short-lived (periods from a few minutes to several hours), GWs are thought to strongly affect the Martian global circulation. They close and even reverse zonal jets in the middle atmosphere (Barnes, 1990; Gilli et al., 2020; Medvedev et al., 2011a) and enhance the meridional circulation, which has implications for the meridional transport of tracers and important dynamical effects. The upwelling part of the meridional cell amplifies the transport of water into the thermosphere (Shaposhnikov et al., 2019), and the descending branch leads to thermospheric polar warmings (Bougher et al., 2006; Medvedev et al., 2011b). GW-induced downward transport Abstract Gravity wave (GW) activity in the lower and middle atmosphere of Mars during the global dust storm of 2018 has been studied for the first time using a high-resolution (GW-resolving) general circulation model. Dust storm simulations were compared with those utilizing the climatological distribution of dust in the absence of storms. Both scenarios are based on observations of the dust optical depth by the Mars Climate Sounder instrument on board the Mars Reconnaissance Orbiter. The modeling reveals a reduction of the wave activity by a factor of 2 or more in the lower atmosphere, which qualitatively agrees with recent observations. It is associated with a decline of GW generation due to baroclinic and convective stabilization of the Martian troposphere induced by the increased amount of airborne aerosols during the storm. Contrary to the decrease of GW activity in the lower atmosphere, wave energy and momentum fluxes in the middle atmosphere increase by approximately the same factor. This enhancement of GW activity is caused by the changes in the large-scale circulation, most importantly in the mean zonal wind, which facilitate vertical wave propagation by allowing for a greater portion of GW harmonics originated in the lower atmosphere to avoid filtering on their way to upper layers. Plain Language Summary Gravity waves (GWs) are oscillations of wind, temperature, pressure, and density that originate in the dense lower atmosphere. They grow in amplitude upon propagation upward and represent a major driving force in the thinner middle and upper atmosphere. GWs are difficult to account for in general circulation models because their scales are smaller than the resolution of the majority of such models. To circumvent this, we employ a high-resolution model that can explicitly ...