Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice

Majid, Sabhiya; Khanduja, Krishan Lal; Gandhi, Rajinder Kaur; Kapur, Sanjay; Sharma, Rati

doi:10.1016/0006-2952(91)90457-g

Cited by 66 publications

(36 citation statements)

References 26 publications

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“…In the present study, the protective action of EA was not affected by prior administration of indomethacin or L-NAME, excluding the possible involvement of endogenous PGs or NO in the mechanism of the EA action. Recent studies showed that polyphenols including EA have antioxidant and antilipid peroxidation activities [6, 7, 8, 9]. It has been reported that quercetin, the polyphenol of a natural flavonol derivative, has several pharmacological effects including gastric mucosal protection [10].…”

Section: Discussionmentioning

confidence: 99%

“…Since the chemical structure of EA is different from that of polyphenols contained in green tea or wine, it is possible that EA has some unique actions on the gastric mucosa which may explain the lesser damage of whisky. Recent studies showed that polyphenols including EA have antioxidant as well as antilipid peroxidation activities [6, 7, 8, 9]. It has been also reported that quercetin, the polyphenol of a natural flavonol derivative, has several pharmacological effects including gastric mucosal protection.…”

Section: Introductionmentioning

confidence: 99%

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Less Damaging Effect of Whisky in Rat Stomachs in Comparison with Pure Ethanol

et al. 2001

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Background/Aim: Ellagic acid (EA), one of the polyphenols that are abundantly contained in whisky as a nonalcoholic component, has antioxidant and anti-inflammatory activities. In the present study, we compared the action of whisky and pure ethanol on the rat gastric mucosa, and examined the role of EA in the less-damaging effect of whisky in the stomach. Methods: Under urethane anesthesia, a rat stomach was mounted in an ex vivo chamber, perfused with saline, and the transmucosal potential difference (PD) was measured before and after exposure to whisky (Yamazaki, Suntory) and ethanol (43%). In a separate study, the animals were given whisky or ethanol (1 ml, 43%) p.o. under unanesthetized conditions, killed 1 h later, and the gastric mucosa was examined for hemorrhagic lesions. Results: Both whisky and ethanol caused a PD reduction, resulting in damage in the stomach, but these responses were less marked in the case of whisky. Although the reduced PD recovered gradually after removal of ethanol, this process was significantly expedited by co-application of EA (80 µg/ml), the recovery rate being much the same as that observed after exposure to whisky. The less-damaging effect of whisky was confirmed in unanesthetized rats after p.o. administration of these agents. In addition, EA (1–30 mg/kg), administered p.o. together with absolute ethanol (99.9%), reduced the severity of gastric lesions induced by ethanol, in a dose-dependent manner, and the effect at 30 mg/kg was equivalent to that obtained by the whisky component containing several low- and high-molecular-weight polyphenols. EA had a scavenging action against both oxygen and hydroxyl radicals in vitro, the effect being equivalent to that of catechol or α-tocopherol. Conclusion: These results suggest that whisky is less irritating to the gastric mucosa, as compared with pure ethanol, and this property of whisky may be explained by EA, one of polyphenols contained in whisky, and its radical scavenging action.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Less Damaging Effect of Whisky in Rat Stomachs in Comparison with Pure Ethanol

et al. 2001

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“…Among these, ellagic acid, rutin and quercetin were found to be major polyphenolic compounds. The antioxidant and anticancer properties of these compounds have been well established [ 28,29,30,31,32 ]. The high level of protective activities imparted by these compounds serves as an evidence for the importance of AME extract in ameliorating the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

Kumar

Arora

Mahajan

et al. 2018

Braz. arch. biol. technol.

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“…Ellagic acid, a dietary polyphenolic compound present in many fruits and nuts, has been reported to possess free radical scavenging, iron chelating and anti-inflammatory activities (Majid et al 1991;Sellappan et al 2002). In previous studies, its potential in reversing Ab42 amyloidassociated neurotoxicity in a mouse model of Alzheimer's disease has been determined (Hartman et al 2006;Feng et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

Mansouri

Farbood

Naghizadeh

et al. 2016

Pharmaceutical Biology

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(2016) Beneficial effects of ellagic acid against animal models of scopolamine-and diazepam-induced cognitive impairments, Pharmaceutical Biology, 54:10, 1947-1953, DOI: 10.3109/13880209.2015 PHARMACEUTICAL BIOLOGY, 2016 VOL. 54, NO. 10, 1947-1953 http://dx.doi.org/10.3109/13880209.2015 Context In a previous study, it has been shown that ellagic acid (EA), a polyphenolic compound found in pomegranate and different berries, prevents cognitive and hippocampal long-term potentiation (LTP) impairments induced by traumatic brain injury in rats through antioxidant and anti-inflammatory mechanisms.Objective The present study was conducted to assess the potential of EA as a memory enhancer. Materials and methodsThe elevated plus maze (EPM) and passive avoidance (PA) paradigm were used to evaluate learning and memory parameters. Three doses (10, 30 and 100 mg/kg, i.p.) of EA were administered to animals. Memory impairment was induced by scopolamine treatment (0.4 mg/kg, i.p.) and/or diazepam (1 mg/kg, i.p.). Acquisition trials were carried out 30 min after scopolamine treatment and retention trials were performed for 5 min 24 h after the acquisition trials.Results EA at doses 30 and 100 mg/kg significantly reversed the amnesia induced by scopolamine (0.4 mg/kg, i.p.) in the EPM and PA tests in mice. Also, EA at doses 30 and 100 mg/kg significantly antagonized the amnesia induced by diazepam (1 mg/kg, i.p.) in EPM test in rats. Moreover, chronic administration of EA at dose 30 mg/kg ameliorated the memory deficit induced by diazepam (1 mg/ kg, i.p.) in rats. Discussion and conclusion This study demonstrates that ellagic acid is effective in preventing scopolamine-and diazepam-induced cognitive impairments without altering the animals' locomotion. This suggests the potential of EA application as a useful memory restorative agent in the treatment of dementia seen in elderly persons.ARTICLE HISTORY

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Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice

Cited by 66 publications

References 26 publications

Less Damaging Effect of Whisky in Rat Stomachs in Comparison with Pure Ethanol

Less Damaging Effect of Whisky in Rat Stomachs in Comparison with Pure Ethanol

Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

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