Influence of emulsifiers on the formation and in vitro anticancer activity of epirubicin loaded PLGA nanoparticles

Eşi̇m, Özgür; Bakırhan, Nurgul K.; Sarper, Meral; Savaşer, Ayhan; Özkan, Síbel A.; Özkan, Yalçın

doi:10.1016/j.jddst.2020.102027

Cited by 21 publications

(16 citation statements)

References 15 publications

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“…In addition, due to the mucoadhesive characteristics, CS-based nanoparticles significantly increase the intestinal absorption of encapsulated drugs after oral administration [ 11 ]. Poloxamer-188 (P-188; Figure 1 D) is the most common surfactant used to develop different nanocarriers due to its eco-friendly, non-ionic characteristics, and good hydrophilic–lipophilic balance [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation of Piperine Nanoparticles: In Vitro Breast Cancer Cell Line and In Vivo Evaluation

et al. 2022

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Piperine (PPN), one of the most investigated phytochemicals, is known to have excellent therapeutic efficacy against a variety of ailments including breast cancer. However, its physicochemical properties such as poor aqueous solubility restrict its clinical application. Therefore, the present investigation was designed to develop PPN encapsulated lipid polymer hybrid nanoparticles (PPN-LPHNPs) to overcome the limitation. The developed PPN-LPHNPs were optimized by the three-factor, three-level Box–Behnken design (33-BBD). The optimized PPN-LPHNPs were then evaluated for their drug release profile, cytotoxicity assay against MDA-MB-231 and MCF-7 cells, and gastrointestinal stability as well as colloidal stability. In addition, the optimized PPN-LPHNPs were evaluated for ex vivo intestinal permeation and in vivo pharmacokinetic in albino Wistar rats. As per the results, the optimized PPN-LPHNPs showed a small average particles size of <160 nm with a low (<0.3) polydispersity index, and highly positive surface charge (>+20 mV). PPN-LPHNPs revealed excellent gastrointestinal as well as colloidal stability and sustained release profiles up to 24 h. Furthermore, PPN-LPHNPs revealed excellent cytotoxicity against both MDA-MB-231 and MCF-7 cancer cells compared to the free PPN. Moreover, animal studies revealed that the PPN-LPHNPs exhibited a 6.02- and 4.55-fold higher intestinal permeation and relative oral bioavailability, respectively, in comparison to the conventional PPN suspension. Thus, our developed LPHNPs present a strong potential for improved delivery of PPN.

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Section: Introductionmentioning

confidence: 99%

Formulation of Piperine Nanoparticles: In Vitro Breast Cancer Cell Line and In Vivo Evaluation

et al. 2022

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“…However, the drug encapsulation efficiency is low, and the residual organic solvents is still an urgent problem to be solved [39]. Phase separation technology and nano-precipitation method are also methods to obtain PLGA micro/ nanoparticle with controllable release ability by simple preparation process [40,41]. In addition, the nanoprecipitation method can complete the preparation of particles in one step, and it is simpler and more effective than emulsification method to encapsulate drugs [42].The salting-out method is an improved emulsification technique, which is suitable for high-concentration polymer solutions and is beneficial to the encapsulation of heat-sensitive drugs [43].…”

Section: Preparation Methods Of Plga Micro/nanoparticlementioning

confidence: 99%

PLGA-based drug delivery system for combined therapy of cancer: research progress

et al. 2021

Mater. Res. Express

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In recent years, PLGA micro/nano particle drug delivery systems has been widely used in cancer treatment. According to the unique properties of PLGA, carriers of various structures are designed to keep the function of drugs or bioactive substances, ensure the effective load of molecules and improve the bioavailability of drugs in diseased parts. PLGA is one of the earliest and most commonly used biodegradable materials. It is often used for functional modification with other polymers (such as polyethylene glycol and chitosan) or other molecules (such as aptamers and ligands) to deliver various small molecule drugs (such as DOX and DTX) and bioactive macromolecules (such as proteins and nucleic acids) to improve targeting, controlled release and therapeutic properties. In this paper, the preparation methods, physical and chemical properties and medical applications of PLGA micro/nano particles are discussed. We focused on the recent research progress of the PLGA-based drug carrier system in tumor combination therapy.

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“…The cholic acid-coated nanoparticles had the smallest particle size and thus exhibited the strongest anticancer effect of the encapsulated epirubicin. [ 398 ] Enhancement of anti-cancer activity Folic acid-poloxamer 407 conjugate Vegetable oil 77.18 ± 1.27 nm Hoechst, Dil BJ5ta cells, Hela cells Vegetable oil nanoparticles modified with Folic acid-poloxamer 407 conjugate showed higher uptake into cancer cells and drug release at lysosomes compared to PEGylated albumin-based nanoparticles. [ 399 ] Enhancement of anti-cancer activity Methotrexate-poloxamer 407 conjugate, folic acid-poloxamer 407 conjugate Vegetable oil 91.3 ± 24.4 Methotrexate Caco-2 cells Vegetable oil nanoparticles coated with methotrexate-poloxamer 407 conjugate showed a stronger anticancer effect compared to the group coated with Folic acid-poloxamer 407 conjugate.…”

Section: Application Of Surfactant-coated Nanoparticles In Nanomedicinementioning

confidence: 99%

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Miyazawa¹,

Itaya²,

Burdeos³

et al. 2021

IJN

115

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Surfactants, whose existence has been recognized as early as 2800 BC, have had a long history with the development of human civilization. With the rapid development of nanotechnology in the latter half of the 20th century, breakthroughs in nanomedicine and food nanotechnology using nanoparticles have been remarkable, and new applications have been developed. The technology of surfactant-coated nanoparticles, which provides new functions to nanoparticles for use in the fields of nanomedicine and food nanotechnology, is attracting a lot of attention in the fields of basic research and industry. This review systematically describes these "surfactant-coated nanoparticles" through various sections in order: 1) surfactants, 2) surfactant-coated nanoparticles, application of surfactant-coated nanoparticles to 3) nanomedicine, and 4) food nanotechnology. Furthermore, current progress and problems of the technology using surfactant-coated nanoparticles through recent research reports have been discussed.

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Influence of emulsifiers on the formation and in vitro anticancer activity of epirubicin loaded PLGA nanoparticles

Cited by 21 publications

References 15 publications

Formulation of Piperine Nanoparticles: In Vitro Breast Cancer Cell Line and In Vivo Evaluation

Formulation of Piperine Nanoparticles: In Vitro Breast Cancer Cell Line and In Vivo Evaluation

PLGA-based drug delivery system for combined therapy of cancer: research progress

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

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