Influence of Estrogens on Total Serum Copper and Caeruloplasmin.

Russ, Ella M.; Raymunt, Julie

doi:10.3181/00379727-92-22512

Cited by 107 publications

(26 citation statements)

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“…The level of copper in the plasma is sufficient to account for a signal of this size (94.3 Utg/ 100 ml plasma -Hrgovcic et al, 1968) and 96% of this copper is bound to ac2+3-globulin in the form of ceruloplasmin. This copper-containing serum enzyme acts as a ferroxidase and is the molecular link between copper and iron metabolism in the body (Frieden, 1970 (Russ and Raymunt, 1956;Gault, Stein and Aronoff, 1966), and this could probably account for the overall elevation of the signal, if this is indeed due to ceruloplasmin. The reasons for the variations are as yet unknown since the ceruloplasmin level of the blood normally does not show any great variation in a healthy individual.…”

Section: Methodsmentioning

confidence: 99%

A Study of Electron Spin Resonance Spectra of Whole Blood from Normal and Tumour Bearing Patients

Foster¹,

Pocklington²,

Miller³

et al. 1973

Br J Cancer

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Summary.-Electron spin resonance spectra have been obtained from samples of frozen whole blood or separated blood cells and plasma. Blood samples were obtained from human controls having no diagnosed malignancy and from patients with a variety of benign and malignant tumours.The characteristic spectrum from control blood shows two main lines with g values of 4-2 and 2-049. Several smaller lines can also be observed. The line at g = 2-049 may be due to the copper protein ceruloplasmin. Although no qualitative differences could be found between the spectra from controls and cancer patients, samples from patients with certain types of tumour showed a significant increase in size of the g = 2-049 signal above control values. This was most noticeably the case with Hodgkin's disease and to a lesser extent with cancers of the breast. Squamous cell carcinomata, taken as a group, did not show an elevation in average size of the g = 2-049 signal. In this latter group, however, there were some indications that the effects of chemotherapeutic treatment could be followed during the early stages of such treatment. Examples are given in which onset of treatment with various cytotoxic agents was associated with reduction in size of the g = 2-049 signal.

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Section: Methodsmentioning

confidence: 99%

A Study of Electron Spin Resonance Spectra of Whole Blood from Normal and Tumour Bearing Patients

Foster¹,

Pocklington²,

Miller³

et al. 1973

Br J Cancer

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“…Measurement of changes in other circulating transport proteins may also be of value in following the status of pregnancy. It has been shown that plasma cortisol levels, the cortisol-binding protein (transcortin), ceruloplasmin, iron-binding globulin, and haptoglobin are all increased during the administration of large amounts of estrogen or during normal pregnancy (35)(36)(37)(38)(39)(40)(41)(42)(43)(44). It Comparison of the method with assessments of protein-bound iodine, serum chorionic gonadotropin, and vaginal smears indicated its greater precision in predicting the outcome of threatened abortions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Vaginal Smear, Serum Gonadotropin, Protein-Bound Iodine, and Thyroxine-Binding as Measures of Placental Adequacy*

Nicoloff¹,

Nicoloff²,

Dowling³

1962

J. Clin. Invest.

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During pregnancy the characteristic increase in the thyroxine-binding capacity of the circulating globulin, TBG (1-3), is associated with a retarded rate of thyroxine turnover (4) and an increase in the concentration of hormonal iodine (PBI) in the plasma (1-4). These alterations in iodine metabolism have not been found in women with choriocarcinomas who excrete large quantities of chorionic gonadotropin (5), but do occur in nonpregnant individuals given large quantities of estrogens (6-8). It has been concluded, therefore, that during pregnancy these phenomena result from systemic effects of placental estrogens. Moreover, the sera of aborting women often fail to show the characteristic increase in serum PBI (9) and in thyroxine-binding by TBG (2).In the past, attempts have been made to use the concentration of PBI as an indicator of fetal viability (9, 10); however, as appears to be true of studies of urinary or plasma chorionic gonadotropin determinations, pregnandiol and estrogen levels, and vaginal smears (11-15), the PBI has not proved satisfactory for routine use. It appeared possible, however, that assessment of TBG might prove of value as an indicator of placental function. For that reason a technique was developed for rapidly estimating serum thyroxinebinding, and its value in predicting the outcome *

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“…Hypercupremia may be produced in human subjects by estrogen administration (25) and is present in pregnant women (26) in whom there is a high level of circulating estrogens. In subjects with cirrhosis of the liver, there are many manifestations of excessive estrogenic stimulation because of the diminished capacity of the liver to "inactivate" the circulating estrogens (27).…”

Section: Discussionmentioning

confidence: 99%