Influence of exercise-induced maternal stress on fetal outcome in Wistar rats: Inter-generational effects

Pinto, Martina L.; Ps, Shetty

doi:10.1079/bjn19950070

Cited by 35 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exercise during pregnancy leads to a reduced birth weight in the offspring and a hypotrophic intrauterine development (20). At P7, RUN pups were significantly lighter than CTR ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring

Bick-Sander

Steiner

Wolf

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Voluntary wheel running of mice in pregnancy and lactation led to a twofold increase in hippocampal precursor-cell proliferation and in the number of Prox1-expressing lineage-determined cells at postnatal day 8 (P8). At P36, the number of newly generated granule cells approximately doubled, resulting in a 40% higher total number of granule cells in pups from running dams as compared with controls. Cell proliferation at embryonic day 15 (E15), in contrast, was decreased in the progeny of exercising mice, and the birth weight was reduced. At P49, body weight had normalized, and hippocampal neurogenesis was not different between the two groups. mRNA for FGF2 was expressed at higher levels at E15 and P8 in runner pups, whereas VEGF was increased only at E15. Insulin-like growth factor did not show differences at any time point. At P36, no differences for any of the factors were found. Our data indicate that maternal behavior and physical activity affects infantile growth-factor expression and can transiently stimulate postnatal hippocampal development in the offspring.

show abstract

“…Exercise during pregnancy leads to a reduced birth weight in the offspring and a hypotrophic intrauterine development (20). At P7, RUN pups were significantly lighter than CTR ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring

Bick-Sander

Steiner

Wolf

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…In the malnourished colony, the proportion of "small-forgestational-age" offspring was ten times higher than that for the well-nourished colony [93]. Similarly, Pinto et al recently reported the cumulative effects of exercise stress over successive generations [94].…”

Section: Effects Present In the F1 Persisting To The F2 And Beyondmentioning

confidence: 91%

Sexual dimorphism in environmental epigenetic programming

Gabory

Attig

Junien

2009

Molecular and Cellular Endocrinology

249

196

View full text Add to dashboard Cite

The phenotype of an individual is the result of complex interactions between genotype and current, past and ancestral environment leading to a lifelong remodelling of our epigenomes. The vast majority of common diseases, including atherosclerosis, diabetes, osteoporosis, asthma, neuropsychological and autoimmune diseases, which often take root in early development, display some degree of sex bias, very marked in some cases. This bias could be explained by the role of sex chromosomes, the different regulatory pathways underlying sexual development of most organs and finally, lifelong fluctuating impact of sex hormones. A substantial proportion of dimorphic genes expression might be under the control of sex-specific epigenetic marks. Environmental factors such as social behaviour, nutrition or chemical compounds can influence, in a gender-related manner, these flexible epigenetic marks during particular spatiotemporal windows of life. Thus, finely tuned developmental program aspects, for each sex, may be more sensitive to specific environmental challenges, particularly during developmental programming and gametogenesis, but also throughout the individual's life under the influence of sex steroid hormones and/or sex chromosomes. An unfavourable programming could thus lead to various defects and different susceptibility to diseases between males and females. Recent studies suggest that this epigenetic programming could be sometimes transmitted to subsequent generations in a sex specific manner and lead to transgenerational effects (TGEs).This review summarizes the current understanding in the field of epigenetic programming and highlights the importance of studying both sexes in epidemiological protocols or dietary interventions both in humans and in experimental animal models.

show abstract

“…Although most attention has been given to the 'first generation' of offspring exposed to a manipulation when in utero, there is a substantial body of evidence from animal studies that programmed phenomena can be perpetuated in later generations. Animal models of prenatal programming by nutrition or exercise, and postnatal programming by nutrition or handling have shown effects on birth weight (Stewart et al 1975, Pinto & Shetty 1995, glucose tolerance (Martin et al 2000, Patel et al 2001) and the hypothalamic-pituitary axis (Francis et al 1999) in subsequent generations.…”

Section: Intergenerational Effects In Animal Models Of Programmingmentioning

confidence: 99%

The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk

Drake¹,

Walker²

2004

Journal of Endocrinology

383

276

View full text Add to dashboard Cite

Many epidemiological studies in diverse populations have demonstrated a link between low birth weight and subsequent disease. This evidence has given rise to the fetal origins hypothesis, which suggests that exposure of the fetus to an adverse environment in utero leads to permanent programming of tissue function and a risk of cardiovascular disease. An alternative hypothesis is that low birth weight and adult cardiovascular disease are independent features of a genetic predisposition to cardiovascular disease. This review describes evidence that the programming phenomenon may not be limited to the first generation offspring. Results of human and animal studies identify intergenerational programmed effects on both birth weight and cardiovascular disease. This may represent a mechanism for the non-genetic inheritance of a predisposition to low birth weight and adverse cardiovascular risk across a number of generations.

show abstract

Influence of exercise-induced maternal stress on fetal outcome in Wistar rats: Inter-generational effects

Cited by 35 publications

References 15 publications

Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring

Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring

Sexual dimorphism in environmental epigenetic programming

The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk

Contact Info

Product

Resources

About