Influence of genetic polymorphism on pesticide-induced oxidative stress

Costa, Chiara; Miozzi, Edoardo; Teodoro, Michele; Fenga, Concettina

doi:10.1016/j.cotox.2018.12.008

Cited by 13 publications

(15 citation statements)

References 51 publications

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“…Many efforts, focusing on the mechanisms of oxidative stress and the role played by the genetic profile in terms of susceptibility, have been conducted [ 14 , 15 , 16 ]. Recently, different studies have demonstrated that gut microbiota (GM) can be affected and altered by different types of environmental pollutants, including some pesticides [ 17 ], therefore the role of the gut microbiota in pesticide-induced toxicity in non-target organisms is gaining increasing attention [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides’ toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host–microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.

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Section: Introductionmentioning

confidence: 99%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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“…Similar toxic effects were also observed for widely used insecticide, neonicotinoid (dinotefuran, nitenpyram, and acetamiprid) exposure, which resulted in disturbance of amino acid metabolism, accumulation of lipids, and enhance oxidative stress in ICR mice via decreasing glutathione (GSH) level and increasing superoxide dismutase (SOD) level ( Yan et al, 2020 ). Polymorphism in oxidative stress-related genes (catalase, glutathione peroxidase, glutathione- S -transferases, manganese superoxide dismutase, and paraoxonase) may not be directly linked to cancer; instead, they make people more vulnerable to pesticide-induced oxidative stress ( Kaur et al, 2018 ; Moradi et al, 2018 ; Costa et al, 2019 ; Mbah Ntepe et al, 2020 ).…”

Section: Pesticides’ Role In Cancermentioning

confidence: 99%

Current status of pesticide effects on environment, human health and it’s eco-friendly management as bioremediation: A comprehensive review

et al. 2022

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Pesticides are either natural or chemically synthesized compounds that are used to control a variety of pests. These chemical compounds are used in a variety of sectors like food, forestry, agriculture and aquaculture. Pesticides shows their toxicity into the living systems. The World Health Organization (WHO) categorizes them based on their detrimental effects, emphasizing the relevance of public health. The usage can be minimized to a least level by using them sparingly with a complete grasp of their categorization, which is beneficial to both human health and the environment. In this review, we have discussed pesticides with respect to their global scenarios, such as worldwide distribution and environmental impacts. Major literature focused on potential uses of pesticides, classification according to their properties and toxicity and their adverse effect on natural system (soil and aquatic), water, plants (growth, metabolism, genotypic and phenotypic changes and impact on plants defense system), human health (genetic alteration, cancer, allergies, and asthma), and preserve food products. We have also described eco-friendly management strategies for pesticides as a green solution, including bacterial degradation, myco-remediation, phytoremediation, and microalgae-based bioremediation. The microbes, using catabolic enzymes for degradation of pesticides and clean-up from the environment. This review shows the importance of finding potent microbes, novel genes, and biotechnological applications for pesticide waste management to create a sustainable environment.

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“…The main challenge in occupational exposure assessment originates from the variability in individual response and genetic susceptibility, revealing diverse sensitivity to xenobiotics. In fact, certain individuals seem to be at a higher risk of pesticide-induced oxidative stress due to the presence of genetic polymorphisms which influence the metabolism of such xenobiotics (28,29). Some of these genetic polymorphisms have been widely studied.…”

Section: Association Between Oxidative Stress Biomarkers and Pon And Gst Polymorphisms As A Predictormentioning

confidence: 99%

Association between oxidative stress biomarkers and PON and GST polymorphisms as a predictor for susceptibility to the effects of pesticides

et al. 2020

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Low levels of pesticides persist in the environment and can affect the health of exposed subjects. Oxidative stress is considered as one of the mechanisms responsible for the adverse effects on human health and some molecules may represent useful biomarkers for the evaluation of this physiological balance. This study investigated the role of these biomarkers, such as advanced oxidation protein products (AOPP), advanced glycation end-products (AGE) and reactive oxygen metabolites (ROMs) in relation to genetic polymorphisms of paraoxonase (PON)1, PON2, glutathione S-transferase pi 1 (GSTP1), glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase mu 1 (GSTM1). An increase in the levels of these biomarkers is usually inversely associated with the depletion of the biological antioxidant potential (BAP). The results revealed a statistically significant difference in the sex-dependent variation of AGE, BAP, AOPP and ROM protein levels. Furthermore, an association between the PON2 S331c gene polymorphism and the serum levels of AOPP, ROMs and BAP was found. Thus, compared with AGE, the levels of AOPP and ROMs provided a more sensitive biomarker, with an improved association with the PON2 genotype. Such an association strengthen the importance of PON in the occurrence of oxidative stress. According to these results, an individual's genetic background may be taken into account for the health surveillance of individuals occupationally exposed to pesticides, in order to define a cluster of highly susceptible workers so as to guarantee greater protection.

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Influence of genetic polymorphism on pesticide-induced oxidative stress

Cited by 13 publications

References 51 publications

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Current status of pesticide effects on environment, human health and it’s eco-friendly management as bioremediation: A comprehensive review

Association between oxidative stress biomarkers and PON and GST polymorphisms as a predictor for susceptibility to the effects of pesticides

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