Influence of glyco-oxidation on complexes between fibrin(ogen) and insulin-like growth factor-binding protein-1 in patients with diabetes mellitus type 2

Gligorijević, Nevenka; Penezić, Ana; Nedić, Olgica

doi:10.1080/10715762.2016.1268689

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Additionally, fibrinogen and insulin-like growth factor- (IGF-) binding protein 1 are tightly connected to metabolic changes and vascular complications in patients with diabetes mellitus. The complexes of these two proteins have been shown to undergo glycoxidation, which reduces their stability and is possibly implicated in the hypercoagulation observed in type 2 DM [138].…”

Section: Roles Of Ales and Ages In Age-related Chronic Diseasesmentioning

confidence: 99%

Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases

Moldogazieva

Mokhosoev

Melnikova

et al. 2019

Oxidative Medicine and Cellular Longevity

355

222

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Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living organisms and is denoted as a persistent condition of an imbalance between the generation of reactive oxygen species (ROS) and the ability of the endogenous antioxidant system (AOS) to detoxify them. The oxidative stress theory has been confirmed in many animal studies, which demonstrated that the maintenance of cellular homeostasis and biomolecular stability and integrity is crucial for cellular longevity and successful aging. Mitochondrial dysfunction, impaired protein homeostasis (proteostasis) network, alteration in the activities of transcription factors such as Nrf2 and NF-κB, and disturbances in the protein quality control machinery that includes molecular chaperones, ubiquitin-proteasome system (UPS), and autophagy/lysosome pathway have been observed during aging and age-related chronic diseases. The accumulation of ROS under oxidative stress conditions results in the induction of lipid peroxidation and glycoxidation reactions, which leads to the elevated endogenous production of reactive aldehydes and their derivatives such as glyoxal, methylglyoxal (MG), malonic dialdehyde (MDA), and 4-hydroxy-2-nonenal (HNE) giving rise to advanced lipoxidation and glycation end products (ALEs and AGEs, respectively). Both ALEs and AGEs play key roles in cellular response to oxidative stress stimuli through the regulation of a variety of cell signaling pathways. However, elevated ALE and AGE production leads to protein cross-linking and aggregation resulting in an alteration in cell signaling and functioning which causes cell damage and death. This is implicated in aging and various age-related chronic pathologies such as inflammation, neurodegenerative diseases, atherosclerosis, and vascular complications of diabetes mellitus. In the present review, we discuss experimental data evidencing the impairment in cellular functions caused by AGE/ALE accumulation under oxidative stress conditions. We focused on the implications of ALEs/AGEs in aging and age-related diseases to demonstrate that the identification of cellular dysfunctions involved in disease initiation and progression can serve as a basis for the discovery of relevant therapeutic agents.

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Section: Roles Of Ales and Ages In Age-related Chronic Diseasesmentioning

confidence: 99%

Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases

Moldogazieva

Mokhosoev

Melnikova

et al. 2019

Oxidative Medicine and Cellular Longevity

355

222

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“…The amount of IGFBP-2/α2M complexes is decreased in patients with CRC, although the total concentration of IGFBP-2 is increased [ 86 ]. Oxidative conditions modify the structure of IGFBP-binding partners, influencing the formation of complexes [ 202 ]. The exact role of these complexes is still unknown, but they contribute to the (re)distribution of IGFBPs between several molecular forms.…”

Section: Insulin-like Growth Factors and Colorectal Cancermentioning

confidence: 99%

The Insulin-like Growth Factor System and Colorectal Cancer

Gligorijević

Dobrijević

Šunderić

et al. 2022

Life

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Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine activities. Together with their receptors, binding proteins and associated molecules, they participate in numerous pathophysiological processes, including cancer development. Colorectal cancer (CRC) is a disease with high incidence and mortality rates worldwide, whose etiology usually represents a combination of the environmental and genetic factors. IGFs are most often increased in CRC, enabling excessive autocrine/paracrine stimulation of the cell growth. Overexpression or increased activation/accessibility of IGF receptors is a coinciding step which transmits IGF-related signals. A number of molecules and biochemical mechanisms exert modulatory effects shaping the final outcome of the IGF-stimulated processes, frequently leading to neoplastic transformation in the case of irreparable disbalance. The IGF system and related molecules and pathways which participate in the development of CRC are the focus of this review.

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“…The first one is responsible for the IGF delivery to the site of injury and the second exploits interaction between the RGD domain in IGFBP-1 and α5β1integrin on cell surfaces initiating cell signalling. Fibrinogen was shown to associate with IGFBP-1 in vivo and its glyco-oxidation reduces the amount of complexes [20].…”

Section: A C C E P T E D Mmentioning

confidence: 99%

Structural changes of fibrinogen as a consequence of cirrhosis

Gligorijević

Minić

Križáková

et al. 2018

Thrombosis Research

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Cirrhosis is a disease which may develop as a consequence of various conditions. In advanced liver disease, blood coagulation can be seriously affected. Portal hypertension, vascular abnormalities and/or a dysbalance in coagulation factors may result in bleeding disorders or in the development of thrombosis. Fibrinogen is the main protein involved in clot formation and wound healing. The aim of this work was to analyse the glycosylation pattern of the isolated fibrinogen molecules by lectin-based protein microarray, together with the carbonylation pattern of the individual fibrinogen chains, possible changes in the molecular secondary and tertiary structure and reactivity with the insulin-like growth factor-binding protein 1 (IGFBP-1) in patients with cirrhosis. The results pointed to an increase in several carbohydrate moieties: tri/tetra-antennary structures, Gal β-1,4 GlcNAc, terminal α-2,3 Sia and α-1,3 Man, and a decrease in core α-1,6 Fuc and bi-antennary galactosylated N-glycans with bisecting GlcNAc. Fibrinogen Aα chain was the most susceptible to carbonylation, followed by the Bβ chain. Cirrhosis induced additional protein carbonylation, mostly on the α chain. Spectrofluorimetry and CD spectrometry detected reduction in the α-helix content, protein unfolding and/or appearance of modified amino acid residues in cirrhosis. The amount of complexes which fibrinogen forms with IGFBP-1, another factor involved in wound healing was significantly greater in patients with cirrhosis than in healthy individuals. A more detailed knowledge of individual molecules in coagulation process may contribute to deeper understanding of coagulopathies and the results of this study offer additional information on the possible mechanisms involved in impaired coagulation due to cirrhosis.

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Influence of glyco-oxidation on complexes between fibrin(ogen) and insulin-like growth factor-binding protein-1 in patients with diabetes mellitus type 2

Cited by 3 publications

References 41 publications

Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases

Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases

The Insulin-like Growth Factor System and Colorectal Cancer

Structural changes of fibrinogen as a consequence of cirrhosis

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