Influence of heat and humidity on the airway obstruction induced by exercise in asthma.

Strauss, Richard; McFadden, E. R.; Ingram, R. H.; Deal, E. C.; Jaeger, J. J.

doi:10.1172/jci108954

Cited by 247 publications

(97 citation statements)

References 17 publications

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“…Eur Respir J., 1996, 9, 716- Isocapnic hyperventilation (ISH) with dry air results in significant water loss from the airways whilst bringing the inspired air to alveolar conditions. The water loss from the airways is the stimulus whereby hyperpnoea provokes airway narrowing [1,2]. Mucociliary clearance (MCC) decreases during and increases after ISH with dry air, compared to ISH with warm humid air and nasal breathing at rest [3].…”

mentioning

confidence: 99%

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Daviskas

Anderson²,

Gonda³

et al. 1996

Eur Respir J

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M Mu uc co oc ci il li ia ar ry y c cl le ea ar ra an nc ce e d du ur ri in ng g a an nd d a af ft te er r i is so oc ca ap pn ni ic c h hy yp pe er rv ve en nt ti il la at ti io on n w wi it th h d dr ry y a ai ir r i in n t th he e p pr re es se en nc ce e o of f f fr ru us se em mi id de e E. Daviskas*, S.D. Anderson*, I. Gonda + , D. Bailey**, G. Bautovich**, J.P. Seale ++ Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide. E. Daviskas, S.D. Anderson, I. Gonda, D. Bailey, G. Bautovich, J.P. Seale. ©ERS Journals Ltd 1996. ABSTRACT: We have previously shown that mucociliary clearance (MCC) decreased during and increased after isocapnic hyperventilation (ISH) with dry air, both in asthmatic and healthy subjects. Inhaled frusemide, an inhibitor of the Na + /K + /2Cl -and NaCl co-transporters on the basolateral membrane of the epithelial cell, prevents the airway narrowing provoked by ISH with dry air. The co-transport system controls epithelial cell volume and chloride secretion and, thus, frusemide has the potential to modify the rate of recovery of periciliary fluid volume during and after ISH with dry air, and hence affect MCC. Frusemide also blocks mediator release from mast cells, which may also modify the increase in MCC after ISH.Eleven asthmatic and 11 healthy subjects inhaled frusemide (35.7±0.44 mg) or its vehicle, from a Fisoneb ™ ultrasonic nebulizer 30 min before ISH with dry air, on two separate occasions. MCC was measured using 99m Tc-sulphur colloid and a gamma camera. Frusemide, compared to its vehicle, did not affect MCC during or 45 min after ISH. However, in the presence of frusemide, the onset of the increase of MCC after ISH was significantly delayed for approximately 10 min in the whole right lung (p<0.002) and central region (p<0.01) in the asthmatic but not in the healthy subjects.These findings could be explained by frusemide delaying the recovery of the periciliary fluid volume after ISH with dry air and/or interfering with the stimulus that causes the increase in MCC in the asthmatic subjects after ISH. Eur Respir J., 1996, 9, 716- Isocapnic hyperventilation (ISH) with dry air results in significant water loss from the airways whilst bringing the inspired air to alveolar conditions. The water loss from the airways is the stimulus whereby hyperpnoea provokes airway narrowing [1,2]. Mucociliary clearance (MCC) decreases during and increases after ISH with dry air, compared to ISH with warm humid air and nasal breathing at rest [3]. The effect of ISH with dry air on MCC is most likely to be due to a reduction of the depth of the periciliary fluid layer, with the subsequent hyperosmolarity leading to release of mediators [4]. Frusemide, a loop diuretic known to inhibit the Na + /K + /2Cl -and NaCl co-transport systems at the basolateral membrane [5], inhibits the airway narrowing induced by exercise [6], ISH [7,8], and hypertonic saline [9]. Inhibition of the co-transport systems affects the regulatory volume increase (RVI) of the ...

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confidence: 99%

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Daviskas

Anderson²,

Gonda³

et al. 1996

Eur Respir J

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“…The mechanism by which exercise causes bronchoconstriction was closely linked to the effect of airway cooling, produced by an increased heat exchange during voluntary hyperventilation with subfreezing air (39,40,(13)(14)(15)(16). Although the final pathways for exercise and CACh are not fully understood, reliable separation of adult patients with asthma from healthy controls was possible by CACh (17).…”

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confidence: 99%

Cold Air Challenge of Airway Hyperreactivity in Children: Practical Application and Theoretical Aspects

et al. 1984

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“…The final model included effects at lags 1 and 2, that is, delayed effects from up to 2 d prior to the day on which the consultation occurred. Sudden changes in temperature have been implicated in the laboratory setting in the onset of asthma symptoms (Ramsey 1977, Strauss et al 1978, O'Byrne et al 1982, Zawadski et al 1988) but no such effect was a significant predictor in our model. Given the anticipated small overall effect size for the daily weather, there was limited power to detect inter-actions.…”

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confidence: 54%

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

Kljakovic¹,

Salmond²

1998

Clim. Res.

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The aim of this study was to build a model showing the relationship between consultations for asthma and the daily weather in a suburban computerised general practice in New Zealand. A retrospective count of the number of asthmatic patients attending the practice on any particular day for a consultation for asthma was compared with the weather variables temperature, rainfall, relative humidity, and wind strength. Quasi-likelihood Poisson regression models were built in steps. There were 3844 consultations for asthma between October 1, 1986 and October 30, 1991. The number varied from 0 to 11 consultations per day (mean 2.1). The annual means were 1.3, 1.9, 2.3, 2.5, and 2.7 consultations per day, respectively. After variables indicating time trends, days of the week, and holiday periods were included in the model, temperature and relative humidity provided the only significant additional explanatory power for variation in consultations.

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Influence of heat and humidity on the airway obstruction induced by exercise in asthma.

Abstract: A B S T R A C T

Cited by 247 publications

References 17 publications

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Mucociliary clearance during and after isocapnic hyperventilation with dry air in the presence of frusemide

Cold Air Challenge of Airway Hyperreactivity in Children: Practical Application and Theoretical Aspects

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

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