Influence of hexadecylphosphocholine (Miltefosine) in phytantriol-based cubosomes: A structural investigation

Malheiros, Barbara; Castro, Raphael Dias de; Lotierzo, Mayra C.G.; Casadei, Bruna Renata; Mariani, Paolo; Barbosa, Leandro R.S.

doi:10.1016/j.colsurfa.2021.127720

Cited by 16 publications

(5 citation statements)

References 52 publications

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“…In order to formulate PHYT cubosomes with antimicrobial features, miltefosine (hexadecylphosphocholine), a broadspectrum antimicrobial drug, was encapsulated (Malheiros et al, 2022). The study showed how the concentration of the drug can induce a phase transition from Pn3m to Im3m; this is a common phenomenon when the drug loading is high or when the drug interferes with the self-assembly properties of the lipid.…”

Section: Lipid Nanoparticles To Tackle Antibiotic Resistancementioning

confidence: 99%

Non-lamellar lipid liquid crystalline nanoparticles: A smart platform for nanomedicine applications

Fornasier

Murgia

2023

Front. Soft. Matter

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The increased interest of the scientific community in lipid nanoparticles has pushed the boundaries of personal medicine and drug delivery. The focus has been set on vesicular nanocarriers, as their structure and functionalities have been well described, but the application of their non-lamellar counterparts, cubosomes and hexosomes, has shown their potency as drug carriers. In addition, the sponge phase dispersion (L3, an intermediate between the lamellar and the bicontinuous cubic) has also been proved effective for the encapsulation of large macromolecules. Their physicochemical characterization has improved in the past decades due to the investigations conducted at high-power synchrotron facilities and the application of surface-sensitive techniques, discovering new connections between physical parameters and biological performance. Several administration routes of cubosomes and hexosomes have been studied, such as intravenous, dermal, transdermal, and oral, to evaluate their cytotoxicity and distribution in biological media. This review aims to summarize the challenges and recent achievements of cubosomes, hexosomes, and sponge nanoparticles as suitable carriers for the administration of bioactives.

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Section: Lipid Nanoparticles To Tackle Antibiotic Resistancementioning

confidence: 99%

Non-lamellar lipid liquid crystalline nanoparticles: A smart platform for nanomedicine applications

Fornasier

Murgia

2023

Front. Soft. Matter

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“…Also, HePC mixed with PHYT induced a higher hydration ability of the polar lipidic surfaces. 71 In a recent study by Meikle et al , functionalized PHYT-based cubosomes composed separately of Ag NPs, copper oxide (Cu 2 O), and magnetite (Fe 3 O 4 ) nanocrystals at 2% w/w were prepared for antibacterial treatment. It was observed that the antimicrobial effectiveness of metal nanocrystals could be preserved in the encapsulated form in both PHYT- and GMO-based cubosomes.…”

Section: Cubosomes – a Potential Vehicle For Drug Deliverymentioning

confidence: 99%

Cubosomes as an emerging platform for drug delivery: a review of the state of the art

et al. 2022

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“…Apart from these two techniques for characterizing cubosomes, three other strategies are critical in cubosomes. They are small-angle X-ray scattering (SAXS), cryo-TEM (cryo TEM), and Energy-dispersive X-ray analysis (EDAX) [ 73 , 74 ]. SAXS is a fairly simple process that is conceptually similar to light scattering.…”

Section: Development Of Cubosomesmentioning

confidence: 99%

Development, Therapeutic Evaluation and Theranostic Applications of Cubosomes on Cancers: An Updated Review

Almoshari

2022

Pharmaceutics

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Cancer is a group of disorders characterized by aberrant gene function and alterations in gene expression patterns. In 2020, it was anticipated that 19 million new cancer cases would be diagnosed globally, with around 10 million cancer deaths. Late diagnosis and interventions are the leading causes of cancer-related mortality. In addition, the absence of comprehensive cancer therapy adds to the burden. Many lyotropic non-lamellar liquid-crystalline-nanoparticle-mediated formulations have been developed in the last few decades, with promising results in drug delivery, therapeutics, and diagnostics. Cubosomes are nano-structured liquid-crystalline particles made of specific amphiphilic lipids in particular proportions. Their ability to encapsulate lipophilic, hydrophilic, and amphiphilic molecules within their structure makes them one of a kind. They are biocompatible, versatile drug carriers that can deliver medications through various routes of administration. Many preclinical studies on the use of cubosomes in cancer treatment and theranostic applications have been conducted. However, before cubosomes may be employed in clinical practice, significant technical advances must be accomplished. This review summarizes the development of cubosomes and their multifunctional role in cancer treatment based on the most recent reports.

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Influence of hexadecylphosphocholine (Miltefosine) in phytantriol-based cubosomes: A structural investigation

Cited by 16 publications

References 52 publications

Non-lamellar lipid liquid crystalline nanoparticles: A smart platform for nanomedicine applications

Non-lamellar lipid liquid crystalline nanoparticles: A smart platform for nanomedicine applications

Cubosomes as an emerging platform for drug delivery: a review of the state of the art

Development, Therapeutic Evaluation and Theranostic Applications of Cubosomes on Cancers: An Updated Review

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