Influence of HLA-DR and -DQ phenotypes on tuberculin reactive status in pulmonary tuberculosis patients

Selvaraj, P.; Reetha, A M; Uma, H.; Xavier, T. Francis; Janardhanam, B.; Prabhakar, R; Narayanan, P R

doi:10.1016/s0962-8479(96)90104-5

Cited by 19 publications

(12 citation statements)

References 10 publications

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“…The HLA-DRB1*07 and -DQA1*0101 alleles are associated with greater susceptibility to the development of pulmonary tuberculosis and the HLA-DQA1*0301 and -DQA1*0501 alleles are associated with protection against this infection [15]. Selvaraj et al (1996) suggested that the heterozygote combination of various HLA-DR antigens influences the tuberculin reaction in pulmonary tuberculosis [16]. Other alleles are not associated with the severity of tuberculosis, but they are associated with predisposition to or protection against its occurrence.…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

Alves¹,

Souza²,

Meyer³

et al. 2006

Braz J Infect Dis

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Many studies have tried to identify genetic markers for infectious diseases, some of them have focused on human leukocyte antigens (HLA). The products of HLA genes interact with surfacespecific receptors of T lymphocytes, resulting in activation of the host's immune response. Association of bacterial, viral, parasitic and fungal infections with the host's HLA has been widely investigated. The type and strength of this association differs among distinct populations, as well as among racial and/or ethnic groups. The new molecular methods for the identification of the HLA alleles, and the resulting new nomenclature, have contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted to clinicians, which hampers the understanding of the association between the HLA system and diseases. We revised relevant studies on the association of HLA genes with infectious diseases, demonstrating their importance in the pathogenic mechanisms, through increased susceptibility or protection against infections and their complications.

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Section: Bacterial Infectionsmentioning

confidence: 99%

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

Alves¹,

Souza²,

Meyer³

et al. 2006

Braz J Infect Dis

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“…In some instances, outbreaks have been identified among patients already receiving treatment for tuberculosis [4]. Bacteriologic characteristics [7,8], host factors such as HIV-positivity [5] and human leukoctye antigen type [9,10], NRAMP1 gene polymorphisms [11], and environmental factors (including the infectiousness of the source case, the period of exposure, local ventilation, and the nature of exposure) may play a role.…”

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confidence: 99%

A Comparison of Outbreak‐ and Nonoutbreak‐Related Multidrug‐Resistant Tuberculosis Among Human Immunodeficiency Virus–Infected Patients in a South African Hospital

et al. 1999

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Nosocomial multidrug-resistant tuberculosis (MDR-TB) in human immunodeficiency virus (HIV)-infected people is recognized in Europe and America. We report the first such outbreak in South Africa. Six hospitalized women, identified by DNA fingerprinting, were infected with an outbreak strain of MDR-TB while receiving treatment for drug-susceptible tuberculosis. The putative source case was identified as an HIV-positive woman who underwent prolonged hospitalization for chronic cavitary tuberculosis. Compared with other HIV-positive patients in the hospital, outbreak patients were more immunocompromised, had fewer cavitary lung changes, and were less likely to have been treated before. They had high fevers, infiltrative patterns on chest radiographs, and a mean survival of 43 days. When individual isolation is not possible, separating highly immunocompromised patients with first-time tuberculosis from previously treated patients with cavitary lesions and from those with established drug resistance may reduce nosocomial transmission.

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“…5 Attempts have been made to implicate environmental and hereditary factors. 6,7 While several predisposing conditions such as HIV disease, steroid treatment, and diabetes have been well characterized, many patients with aggressive disease appear to be otherwise immunologically normal.…”

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confidence: 99%

Factors Related to In-hospital Deaths in Patients With Tuberculosis

Sacks¹,

Pendle²

1998

Arch Intern Med

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Influence of HLA-DR and -DQ phenotypes on tuberculin reactive status in pulmonary tuberculosis patients

Cited by 19 publications

References 10 publications

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex

A Comparison of Outbreak‐ and Nonoutbreak‐Related Multidrug‐Resistant Tuberculosis Among Human Immunodeficiency Virus–Infected Patients in a South African Hospital

Factors Related to In-hospital Deaths in Patients With Tuberculosis

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