1970
DOI: 10.1097/00000658-197010000-00002
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Influence of Hypercalcemia on Gastric Secretion and Serum Gastrin Concentrations in Man

Abstract: Studies of the effect of elevated levels of serum calcium on gastric secretion in dogs 1 7 indicate that there is no significant stimulation of acid secretion and that some degree of inhibition may occur.' In order to investigate the possible role of the gastrin mechanism in the stimulation of gastric secretion by infusion of calcium, we have studied the effects of the intravenous administration of calcium on gastric acid secretion and on the serum concentration of gastrin in duodenal ulcer patients and in nor… Show more

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Cited by 151 publications
(52 citation statements)
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“…Although studies reporting the effect of calcium on the increase in gastric acidity are intense (2)(3)(4)7,8), other literature reports focus on either increased pepsinogen (3,7) or increased gastrin levels (2,9,10 (12). In contrast, we had no mortalities.…”
Section: Discussionmentioning
confidence: 53%
“…Although studies reporting the effect of calcium on the increase in gastric acidity are intense (2)(3)(4)7,8), other literature reports focus on either increased pepsinogen (3,7) or increased gastrin levels (2,9,10 (12). In contrast, we had no mortalities.…”
Section: Discussionmentioning
confidence: 53%
“…If glucagon inhibits gastrin synthesis, the antral gastrin concentration will not increase so markedly as we observed in this study. The mechanism involved is, at least in part, the decrease of plasma calcium concentration by glucagon, as calcium has been demonstrated by in vivo (Reeder et al 1970;Passaro et al 1972) and in vitro (Harty et al 1981) experiments to be an important factor in the regulation of gastrin release.…”
Section: Discussionmentioning
confidence: 99%
“…In the dog, however, the serum gastrin concentration did ' not change during infusion of calcium (Reeder et al, 1970). On the contrary, some inhibition of gastric acid secretion may occur (Allen & Elliott, 1971).…”
Section: Introductionmentioning
confidence: 99%