Influence of<i>Panax ginseng</i>on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia

Kim, Su Kang; Chung, Joo‐Ho; Lee, Byung-Cheol; Lee, Sang Won; Lee, Kang Hyo; Kim, Young Ock

doi:10.5213/inj.2014.18.4.179

Cited by 19 publications

(18 citation statements)

References 31 publications

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“…P. ginseng was kindly gifted from the Department of Medicinal Crop Research (Eumsung-gun, Chungbuk, Korea) (Kim et al, 2014, Kim et al, 2015a, Kim et al, 2015b).…”

Section: Methodsmentioning

confidence: 99%

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Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia

Kim

GyuKo

Chung

et al. 2018

Saudi Journal of Biological Sciences

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The prostatic hyperplasia in benign prostatic hyperplasia (BPH) leads to obstructive micturition symptoms. Previous studies showed that pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial preopticnucleus (MPA) regions in the brain have been known to regulate the urinary bladder function. The present study shows the influences of on nerve growth factor (NGF) expressions in PMC, vlPAG, and MPA regions in the brain. Wistar rats were used for the present study. The rats split into four groups; 4 groups ( = 6) in control group, BPH-induced group, BPH-induced and treated group, and BPH-induced and finasteride-treated group. BPH in rats was induced by testosterone and the animals were evaluated for NGF expression in PMC, vlPAG, and MPA regions in the brain. The NGF expression was identified using immunohistochemistry (IHC). The NGF expression by IHC showed spots with dark brown color. In our results, NGF expressions in PMC, vlPAG, and MPA regions in the brainstem of the BPH-induced group showed increase than the control animal. These increased NGF expressions in three regions were decreased using treatment with (200 mg/kg). These results suggest that has therapeutic effects on the symptoms of BPH and is associated with the regulation of NGF expression in the brain. In conclusion, the administration of helps nerve growth factor activation.

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“…P. ginseng was kindly gifted from the Department of Medicinal Crop Research (Eumsung-gun, Chungbuk, Korea) (Kim et al, 2014, Kim et al, 2015a, Kim et al, 2015b).…”

Section: Methodsmentioning

confidence: 99%

“…Previous study showed that the Panax ginseng CAMAYER ( P. ginseng ) protected development of prostate in the rats (Kim et al, 2014, Kim et al, 2015a, Kim et al, 2015b, Park et al, 2017a, Park et al, 2017b). However, PMC, vlPAG, and MPA regions in the brain have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia

Kim

GyuKo

Chung

et al. 2018

Saudi Journal of Biological Sciences

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“…The KRG known so far has been reported to be effective as an antioxidant, antibacterial agent, anti-inflammatory action agent, blood circulation enhancer, cancer preventing agent, and infectious defense and immunity enhance [9–13]. KRG is also commonly used for male rejuvenation [14, 15] and, to treat urinary discomfort in the elderly, as it is known in Korea as a herb that improves vigor and stamina [16, 17].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Korea Red Ginseng on Inflammatory Cytokines and Apoptosis in Rat Model with Chronic Nonbacterial Prostatitis

Kang

Park

Seok

et al. 2019

BioMed Research International

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Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. To induce CNP, rats were castrated and beta-estradiol (0.25 mg/kg) was subcutaneously (s.c.) injected daily. 7-week-old male Wistar rats were divided into 5 groups (the normal group, CNP group, positive group, and KRG group (0.25g/kg) and another KRG (0.50g/kg) group. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed. Compared to the positive group, the KRG groups (0.25g/kg and 0.50g/kg) showed similar protective properties on CNP based on the histopathologic morphology of the prostate and the inflammation cytokines in the prostate tissue. Also, results of the immunohistochemistry staining showed that expression levels of vascular endothelial growth factor A (VEGFA), interleukin 6 (IL6), interleukin 1 beta (IL-1ß), tumor necrosis factor (TNF-alpha), and cytochrome c oxidase subunit II (COX2) were also decreased in KRG group (0.25g/kg) and KRG group (0.50g/kg). These results suggested that KRG inhibited the development of CNP and might a useful herbal treatment or functional food for CNP.

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“… 29 In BPH rat prostate weight and volume were increased, resulting in higher α1-adrenoceptor than normal rats. 30 Because administration of finasteride reduced the volume of the prostate, it may decrease α1-adrenoceptors. In this study, we observed increased α1-adrenoceptor expression in the prostate tissue of BPH model rats, while both LDD175 alone (BPH+L group) and in combination (BPH+LTF group) reduced α1-adrenoceptor expression compared to disease control group, with the combination therapy more effective.…”

Section: Discussionmentioning

confidence: 99%

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

Choi¹,

Kim²,

Soni³

et al. 2018

DDDT

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ObjectiveWe investigated the benefits of the BKCa agonist 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid (LDD175) combined with tamsulosin and finasteride, in a benign prostatic hyperplasia (BPH) rat model.Materials and methodsCastration was performed by bilateral orchiectomy under ketamine anesthesia. A rat model of BPH was established by daily intramuscular administration of testosterone propionate plus 17β-estradiol for 8 weeks. Model rats were administered combinations of 20 mg/kg LDD175, 0.01 mg/kg tamsulosin and 1 mg/kg finasteride once daily by oral gavage for 4 weeks from week 6 to 9 post-surgery. Intraurethral pressure induced by electrostimulation of the hypogastric nerve was measured at the end of administration. Body and genitourinary organ weights were recorded, serums were assayed for hormone concentrations, and tissues were subjected to histopathology, and analyses of α1-adrenoceptor mRNA and protein expression levels after treatment.ResultsCombined LDD175, tamsulosin, and finasteride significantly decreased prostatic index, serum hormone levels, epithelial thickness, and prostate expression of α1-adrenoceptors in BPH model rats. The 3-drug combination was more effective than any other combination or LDD175 alone.ConclusionThese results suggest that LDD175 addition to tamsulosin and finasteride may be beneficial for the treatment of BPH patients who do not respond to tamsulosin plus finasteride.

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Influence ofPanax ginsengon Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia

Cited by 19 publications

References 31 publications

Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia

Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia

The Effects of Korea Red Ginseng on Inflammatory Cytokines and Apoptosis in Rat Model with Chronic Nonbacterial Prostatitis

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

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