Influence of increasing body mass index on semen and reproductive hormonal parameters in a multi-institutional cohort of subfertile men

Bieniek, J; Kashanian, James A.; Deibert, Christopher M.; Grober, Ethan; Lo, Kirk; Brannigan, Robert E.; Sandlow, Jay; Jarvi, Keith

doi:10.1016/j.fertnstert.2016.06.041

Cited by 129 publications

(109 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We also found that for couples undergoing oocyte retrieval cycles for TESA‐ICSI, male BMI was negatively associated with serum T levels and positively associated with E2 levels in males, consistent with several prior studies showing that obesity affects hormone levels in men of reproductive age (Jensen et al, ; MacDonald et al, ; Tunc et al, ). Systemic T is generally aromatised to E2 in adipose cells (Bieniek et al, ); therefore, increased E2 levels are observed in some obese men. E2 forms a negative feedback loop with the pituitary gland in the hypothalamic–pituitary–gonadal axis and probably leads to reduced T levels following lower LH secretion (Pavlovich, King, Goldstein, & Schlegel, ).…”

Section: Discussionmentioning

confidence: 99%

Effects of obesity on sperm retrieval, early embryo quality and clinical outcomes in men with nonobstructive azoospermia undergoing testicular sperm aspiration‐intracytoplasmic sperm injection cycles

Yang

Shi

et al. 2019

Andrologia

View full text Add to dashboard Cite

The objective of this study was to assess the effects of body mass index (BMI) on sperm retrieval, early embryo quality and clinical outcomes in patients with nonobstructive azoospermia (NOA) undergoing testicular sperm aspiration‐intracytoplasmic sperm injection (TESA‐ICSI). A total of 3,005 infertile couples were evaluated between January 2010 and June 2017, including 1585 normal‐weight (BMI < 25 kg/m2), 847 overweight (BMI 25–29.99 kg/m2) and 573 obese (BMI ≥ 30 kg/m2) patients. We found no significant relationship between BMI and sperm retrieval rate (22.4%, 24.3% and 25.1%, p = 0.327) or sperm motility. Among the 705 patients with NOA who underwent TESA‐ICSI cycles, obese individuals had lower T levels and higher E2 levels than normal‐weight and overweight individuals. However, there were no significant differences in other male hormones (follicle stimulating hormone [FSH], luteinizing hormone [LH], or prolactin [PRL]) among the groups. We also found that the sperm parameters, embryo quality and clinical outcomes of patients with NOA undergoing TESA‐ICSI were not influenced by high BMI levels. In conclusion, this study demonstrated a lack of obvious effects of obesity on sperm retrieval, early embryo quality and clinical outcomes in infertile men undergoing TESA‐ICSI cycles, although T and E2 levels were affected.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of obesity on sperm retrieval, early embryo quality and clinical outcomes in men with nonobstructive azoospermia undergoing testicular sperm aspiration‐intracytoplasmic sperm injection cycles

Yang

Shi

et al. 2019

Andrologia

View full text Add to dashboard Cite

show abstract

“…Leptin-deficient mice have central hypogonadism and hence show reduced fertility. Low sperm counts and reduced sperm function have been reported in obese men [82]. Adipocytokines and inflammatory cytokines have all been shown to impact reproductive function and directly interact with the male reproductive system [83].…”

Section: Obesity and Pubertal Onset And Progressionmentioning

confidence: 99%

Putative Effects of Obesity on Linear Growth and Puberty

Shalitin

Kieß²

2017

Horm Res Paediatr

View full text Add to dashboard Cite

Childhood obesity is a major public health problem that has grown to epidemic proportions throughout the world. Obesity is influenced by genetic and environmental factors. The nutritional status plays an important role in growth and body weight regulation. Excess adiposity during childhood can affect the process of growth and puberty. Obese children are frequently tall for their age, with accelerated epiphyseal growth plate maturation despite low growth hormone levels. Several regulatory hormones may affect the process of linear growth in the constellation of obesity, as high levels of insulin and leptin are observed in obese children. Leptin can act as a skeletal growth factor, with a direct effect on skeletal growth centers. The finding that overweight children, especially girls, tend to mature earlier than lean children has led to the hypothesis that the degree of body fatness may trigger the neuroendocrine events that lead to the onset of puberty. Leptin receptors have been identified in the hypothalamus, as well as in gonadotrope cells, ovarian follicular cells, and Leydig cells. The increased leptin and androgen levels seen in obese children may be implicated in their earlier onset of puberty and accelerated pubertal growth. This review is focused on the interaction between childhood obesity and growth and pubertal processes.

show abstract

“…Nevertheless, the studies addressing specific relationships between semen parameters and obesity have yielded contradictory results. Although some recent data suggest a correlation between the increase in obesity and a reduction in sperm concentration, motility and/or morphology (Alshahrani, Ahmed, Gabr, Abalhassan, & Ahmad, ; Belloc et al., ; Bieniek et al., ; Dupont et al., ; Eisenberg et al., ; Luque et al., ; MacDonald, Stewart, & Farquhar, ; Taha et al., ; Umul et al., ), other studies did not detect statistically significant adverse effects of obesity on semen quality (Bandel et al., ; Thomsen, Humaidan, Bungum, & Bungum, ). Although three meta‐analyses were published, the contradictions remain.…”

Section: Introductionmentioning

confidence: 98%

Association between body mass index and sperm quality and sperm DNA integrity. A large population study

et al. 2017

View full text Add to dashboard Cite

This study aimed to analyse whether the functional quality of spermatozoa is associated with body mass index (BMI). Semen samples were obtained from 1824 men undergoing fertility evaluation/treatment. Semen analysis was performed using World Health Organization (WHO) criteria, and morphology was evaluated with the motile sperm organelle morphology examination (MSOME). The percentages of sperm DNA fragmentation (using TdT (terminal deoxynucleotidyl transferase)-mediated dUTP nick-end labelling (TUNEL) assays), sperm chromatin packaging/underprotamination (using chromomycin A3/CMA ), mitochondrial damage (using MitoTracker Green) and apoptosis (using annexin V) were also assessed. At least 200 spermatozoa were examined in each evaluation. The following BMI values were used as cut-off points: ≤24.9 kg/m , 25-29.9 kg/m (overweight) and ≥30 kg/m (obese). High BMI negatively affects sperm concentration, vitality, motility and morphology (p < .05). Conversely, high BMI does not seem to be associated with impaired sperm DNA integrity, as assessed by DNA fragmentation, sperm protamination and sperm apoptosis (p > .05). However, increased BMI is associated with increased mitochondrial damage in spermatozoa (p < .05). In conclusion, given the adverse consequences of obesity and the possible effect of male BMI on assisted reproduction technology (ART) outcomes, the benefits of weight reduction should be discussed when counselling couples interested in fertility treatment.

show abstract

Influence of increasing body mass index on semen and reproductive hormonal parameters in a multi-institutional cohort of subfertile men

Abstract: In one of the largest cohorts of male fertility and obesity, serum hormone and semen parameters demonstrated mild but significant relationships with BMI, possibly contributing to subfertility in this population.

Cited by 129 publications

References 38 publications

Effects of obesity on sperm retrieval, early embryo quality and clinical outcomes in men with nonobstructive azoospermia undergoing testicular sperm aspiration‐intracytoplasmic sperm injection cycles

Effects of obesity on sperm retrieval, early embryo quality and clinical outcomes in men with nonobstructive azoospermia undergoing testicular sperm aspiration‐intracytoplasmic sperm injection cycles

Putative Effects of Obesity on Linear Growth and Puberty

Association between body mass index and sperm quality and sperm DNA integrity. A large population study

Contact Info

Product

Resources

About