Influence of ionic substitution in improving the biological property of carbon nanotubes reinforced hydroxyapatite composite coating on titanium for orthopedic applications

Gopi, D.; Shinyjoy, E.; Kavitha, L.

doi:10.1016/j.ceramint.2014.12.114

Cited by 52 publications

(33 citation statements)

References 33 publications

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“…For 7 days of culture, the multiplicity of cells and amount 13 of cells on the nanocomposite sample (Fig. 44 The cellular viability (cell 3.9 Live/dead cell assay 1 Fig. The 14 optical images suggest that the composite material has compatibility with osteoblast cells and 15 improves the cell growth behavior.…”

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Fabrication of divalent ion substituted hydroxyapatite/gelatin nanocomposite coating on electron beam treated titanium: mechanical, anticorrosive, antibacterial and bioactive evaluations

et al. 2015

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16The key property of the fabrication of a biomaterial is to facilitate the replacement and/or 17 regeneration of damaged tissues and organs. To obtain such a biomaterial, we fabricated triple 18 minerals (strontium, magnesium and zinc) substituted hydroxyapatite/gelatin (M-HAP/Gel) 19 nanocomposite coating in electron beam treated titanium (Ti) metal. The influence of gelatin 20 concentrations in M-HAP was studied with its effect on the morphological changes, crystallinity, 21 mechanical and anticorrosion properties. The M-HAP/Gel nanocomposite coating (with 3 wt% 22 gelatin) on treated Ti resulted in better mechanical and anticorrosion properties as a consequence 23 of electron beam treatment of Ti. A reduced amount of bacterial colonies was observed for the 24 M-HAP/Gel composite against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) 25 microbes which evidences the less chance for the implant failure after implantation. Moreover, 26 the cell proliferation assay, live/dead staining of MT3C3-E1 cells and cell viability of fibroblast 27 stem cells on the resultant nanocomposite revealed that the M-HAP/Gel composite will definitely 28 be an effective implant material for better cell growth in the orthopedic applications.4 should mimic the properties of the natural bone. 1 Recently, hydroxyapatite (HAP, 5Ca 10 (PO 4 ) 6 (OH) 2 ) has been broadly used as a biomaterial due to similar characteristics as that of 6 the natural bone. 2 The HAP structure can accommodate a great variety of other substituents. 7Thus it can readily accept the minerals to mimic as bone like material. Among many mineral 8 ions, strontium (Sr) is an important trace element in human body and enhances preosteoblasts 9 proliferation and decreases bone resorption. 3 In addition, Sr-HAP can exhibit better mechanical 10 properties than pure HAP. 4-7 Zinc (Zn) is required for human as an essential element and its 11 requirement is estimated to be 15 mg day -1 . 8 Also, Zn has antibacterial activity, which minimizes 12 the bacterial load on the implant surface after orthopedic implantation and improves the 13 mechanical strength. 9,10 Similarly, magnesium (Mg) directly stimulates the osteoblast 14 proliferation and helps for the mineralization of calcified tissues which indirectly controls the 15 mineral metabolism. 11-13 Previously, Gopi et al., have developed minerals substituted HAP 16 coating over titanium alloy by pulsed electrodeposition method. 14 17In order to fasten/improve the biological interactions with the surrounding tissues, 18 nowadays, biopolymers such as chitosan, gelatin, etc., has been used. In particular, gelatin, a 19 natural polymer, is composed of unique sequence of amino acids such as glycine, proline and 20 hydroxyproline that motivate wound healing and intensify the osteointegration as well as three 21 dimensional tissue regeneration. 15,16 Moreover, gelatin is obtained by a controlled hydrolysis of 22 fibrous insoluble protein, collagen, which is the major cons tituent of skin, bones and tissues. 17 1 good ...

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Fabrication of divalent ion substituted hydroxyapatite/gelatin nanocomposite coating on electron beam treated titanium: mechanical, anticorrosive, antibacterial and bioactive evaluations

et al. 2015

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“…The formation of barrier apatite film restricted the solution penetration into the bulk substrate, which thereby blocks the chloride ion infiltration to the Ti-cp substrate. Earlier corrosion studies on ionic doped HA coatings show similar results[7,42].…”

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“…The curves of the specimens shifted to a nobler E corr and a lower i corr . The corrosion rate of a material is proportional to the i corr at a given potential; thus, the materials with higher value of i corr are more prone to corrosion [7]. Compared with the uncoated specimen, the HA coating enhanced the corrosion potential by 93 mV, and the …”

Section: Corrosion Behaviourmentioning

confidence: 99%

“…Moreover, these implants may not promote osteoconductive and osteoblastic phenomena in the host body. Fortunately, the Ti-cp implant osseointegration can be stimulated by surface treatments, such as sand blasting [4], acid etching [5], plasma electrolytic oxidation [6] and hydroxyapatite [HA, Ca 10 (PO 4 ) 6 (OH) 2 ] coatings [7]. Amongst these treatments, artificial HA coatings are widely employed to promote bone ingrowth because of their osteoconductivity and bioactivity.…”

Section: Introductionmentioning

confidence: 99%

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Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant

Huang

Zhang

Qiao

et al. 2016

Ceramics International

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“…Some works [7,[41][42][43] observed the deposition of different kinds of HA coating (with or without reinforcements) on Ti and Ti based alloys using other methods, such as hydrothermal synthesis, electrodeposition, radio frequency sputtering, and plasma spray. These methods made it possible to obtain rather high quality coatings on Ti and Ti based substrates.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Synthesis of the hydroxyapatite coatings on the Ti substrates by mechanical alloying

Zadorozhnyy

Kaevitser

Kopylov³

et al. 2015

Surface and Coatings Technology

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Influence of ionic substitution in improving the biological property of carbon nanotubes reinforced hydroxyapatite composite coating on titanium for orthopedic applications

Cited by 52 publications

References 33 publications

Fabrication of divalent ion substituted hydroxyapatite/gelatin nanocomposite coating on electron beam treated titanium: mechanical, anticorrosive, antibacterial and bioactive evaluations

Fabrication of divalent ion substituted hydroxyapatite/gelatin nanocomposite coating on electron beam treated titanium: mechanical, anticorrosive, antibacterial and bioactive evaluations

Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant

Synthesis of the hydroxyapatite coatings on the Ti substrates by mechanical alloying

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