Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant

Huang, Yong; Zhang, Xuejiao; Qiao, Hongchao; Min, Hang; Zhang, Honglei; Xu, Zhiwei; Zhang, Xiaoyun; Pang, Xin; Lin, He

doi:10.1016/j.ceramint.2015.09.160

Cited by 67 publications

(24 citation statements)

References 58 publications

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“…Among the anions, F − was co‐substituted with Na + , Sr 2+ and Zn 2+ ions (Table ). Huang et al fabricated Sr/F and Zn/F co‐doped HAp coatings on titanium substrates via electrodeposition technique, with the aim to simultaneously improve its corrosion resistance in SBF and biocompatibility. Zn 2+ /F − co‐doping decreased hydroxyapatite unit cell volume, as well as grain sizes.…”

Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

“…Huang et al fabricated Sr/F and Zn/F co‐doped HAp coatings on titanium substrates via electrodeposition technique, with the aim to simultaneously improve its corrosion resistance in SBF and biocompatibility. Zn 2+ /F − co‐doping decreased hydroxyapatite unit cell volume, as well as grain sizes. The obtained co‐substituted films presented lower dissolution rate and remarkably higher density than undoped HAp one, resulting crack‐free and dense.…”

Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

“…The obtained co‐substituted films presented lower dissolution rate and remarkably higher density than undoped HAp one, resulting crack‐free and dense. In vitro potentiodynamic polarization tests evidenced that the Sr/F and Zn/F co‐dopings within HAp lattice led to the increment of the corrosion resistance, due to their higher density and the reduced residual porosity, resulting the obtained coatings totally crack‐free and dense . For example, ZnFHAp coating presented remarkably lower corrosion rate (0.064 mm/y) with respect to undoped HAp‐coated (0.144 mm/y) and uncoated commercially pure titanium (cp‐Ti) (1.02 mm/y), due to the deposition of fewer cracks, adequate thickness, greater compactness and more uniform coatings on the cp‐Ti surface .…”

Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

“…In vitro potentiodynamic polarization tests evidenced that the Sr/F and Zn/F co‐dopings within HAp lattice led to the increment of the corrosion resistance, due to their higher density and the reduced residual porosity, resulting the obtained coatings totally crack‐free and dense . For example, ZnFHAp coating presented remarkably lower corrosion rate (0.064 mm/y) with respect to undoped HAp‐coated (0.144 mm/y) and uncoated commercially pure titanium (cp‐Ti) (1.02 mm/y), due to the deposition of fewer cracks, adequate thickness, greater compactness and more uniform coatings on the cp‐Ti surface . Moreover, this result can be also ascribed to the formation of a dense and nanostructured apatite layer, able to act as a barrier against the solution penetration and the chloride ion infiltration into the bulk Ti substrate, providing sufficient anticorrosive protection …”

Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

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Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Cacciotti

2019

Int J Applied Ceramic Tech

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The biological apatite, whose the bone and teeth mineral phases are composed, remarkably differs from stoichiometric hydroxyapatite (HAp, Ca10(PO4)6(OH)2, Ca/P = 1.667). Indeed, it consists in carbonated Ca‐deficient (Ca/P < 1.667) apatite, characterised by the presence of several vicarious ions, either incorporated within the apatite lattice or just adsorbed on the crystal surface, including anionic (eg, F−, Cl−, SiO44- and CO3=) and/or cationic substitutions (eg, Na+, Mg2+, K+, Sr2+, Zn2+, Ba2+, Al3+). For this reason, recently, a continuous and rising attention has been devoted to the ionic substitutions within the hydroxyapatite lattice in order to resemble the chemical composition of the bone mineral component and to improve its chemical, physical and mostly biological properties, for applications in biomedical sector, particularly in dentistry, orthopaedics and bone tissue engineering. The present manuscript provides a complete overview about the bi‐substituted hydroxyapatites in form of powders and coatings, in order to evidence the effect of the co‐doping with different vicarious ions within HAp lattice on its physicochemical properties, such as microstructure, morphology, thermal stability, solubility, thermal decomposition, dissolution, grain size, mechanical strength, degradation kinetics, corrosion resistance, and biological responsiveness, in terms of in vitro bioactivity, cytotoxicity and antibacterial action.

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Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

Section: Bi‐substituted Hydroxyapatite Coatingsmentioning

confidence: 99%

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Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Cacciotti

2019

Int J Applied Ceramic Tech

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“…Improving the biological and physicochemical properties of HA can be achieved by doping HA with ions that are usually present in natural apatites of vertebrate skeletal systems 17) . Fluorine exists as a trace element in the mineral phase of bone and teeth.…”

Section: Introductionmentioning

confidence: 99%

Application of fluoridated hydroxyapatite thin film coatings using KrF pulsed laser deposition

et al. 2018

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Fluoridated hydroxyapatite (FHA) was investigated for application as an implant coating for titanium bone substitute materials in dental implants. A KrF pulsed excimer deposition technique was used for film preparation on a titanium plate. The compacts were ablated by laser irradiation at an energy density of 1 J/cm 2 on an area 1×1 mm 2 with the substrate at room temparature. Energydispersive spectrometric analysis of the FHA film revealed peaks of fluorine in addition to calcium and phosphorus. X-ray diffraction revealed the presence of crystalline FHA on the FHA film after a 10 h post annealing treatment at 450°C. The FHA film coating exhibited significant dissolution resistance to sodium phosphate buffer for up to 21 days, and favorable cell attachment of human mesenchymal stem cells compared with HA film. The results of this study suggest that FHA coatings are suitable for real-world implantation applications.

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One‐Step Electrodeposition of Multi‐element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants

Jia

Bian

et al. 2023

ChemistrySelect

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The introduction of trace elements into hydroxyapatite (HA) coatings has been widely used for antimicrobial and biocompatible modification of metal implants. In this study, a multifunctional coating of HA co-doped with Cu 2 + , Zn 2 + , Sr 2 + and F À (CuZnSrFHA) was synthesized on titanium substrate by onestep electrodeposition technology. The CuZnSrFHA consisted of nanoscale needle-like crystals with low roughness and poor hydrophilicity. However, it can continuously release Cu 2 + , Zn 2 + and Sr 2 + within 14 days while maintaining good physiological stability. Based on the synergistic effect of Cu and Zn, the CuZnSrFHA coating showed some inhibitory effect on E. coli and S. aureus. Furthermore, the CuZnSrFHA was not significantly cytotoxic and promoted early adhesion and alkaline phosphatase activity of osteoblasts. In conclusion, the multielement co-doped CuZnSrFHA coating was expected to be a novel surface modification material for the prevention of infectious bone defects.

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Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant

Cited by 67 publications

References 58 publications

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Application of fluoridated hydroxyapatite thin film coatings using KrF pulsed laser deposition

One‐Step Electrodeposition of Multi‐element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants

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