Influence of Latanoprost on Retinal Microcirculation in Glaucoma

Iliadou, M; Anastassiou, Gerasimos; Schallenberg, Maurice; Vilser, Walthard; Steuhl, Klaus‐Peter; Selbach, J. Michael

doi:10.2174/1874364101408010060

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Other investigators have found evidence of arteriolar dilation with beta‐blocker use in persons with POAG and ocular hypertensives . Latanoprost has not been found to effect retinal vessel diameter in normal or glaucomatous eyes, however has been found to induce arteriolar constriction in subjects with type 1 diabetes . Another study by Kóthy et al .…”

Section: Glaucomatous and Non‐glaucomatous Optic Neuropathiesmentioning

confidence: 95%

Review of the association between retinal microvascular characteristics and eye disease

Newman

Andrew

Casson

2017

Clinical Exper Ophthalmology

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Computerized retinal imaging technologies enable the static and dynamic measurement of a range of retinal microvascular parameters. Large population-based studies have reported associations between these microvascular indices and various ophthalmic diseases including diabetes, age-related macular degeneration, retinal artery embolism, retinal vein occlusion, glaucoma and non-glaucomatous optic neuropathies. Increasingly, sophisticated imaging and analysis techniques have the potential to provide relevant clinical information regarding disease risk and progression; however, further studies are required to verify associations and strengthen the predictive power of these techniques. We summarize the current state of knowledge regarding retinal microvascular characteristics and eye disease.

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Section: Glaucomatous and Non‐glaucomatous Optic Neuropathiesmentioning

confidence: 95%

Review of the association between retinal microvascular characteristics and eye disease

Newman

Andrew

Casson

2017

Clinical Exper Ophthalmology

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Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects

Zhou

Sabel²

2023

EPMA Journal

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Purpose Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a major factor. To optimize therapy, an improved understanding of concepts of predictive, preventive, and personalized medicine (3PM) is needed which is based on a more detailed understanding of VD pathology. Specifically, to learn if the root cause of glaucomatous vision loss is of neuronal (degeneration) or vascular origin, we now studied neurovascular coupling (NVC) and vessel morphology and their relationship to vision loss in glaucoma. Methods In patients with primary open angle glaucoma (POAG) (n = 30) and healthy controls (n = 22), NVC was studied using dynamic vessel analyzer to quantify retinal vessel diameter before, during, and after flicker light stimulation to evaluate the dilation response following neuronal activation. Vessel features and dilation were then related to branch level and visual field impairment. Results Retinal arterial and venous vessels had significantly smaller diameters in patients with POAG in comparison to controls. However, both arterial and venous dilation reached normal values during neuronal activation despite their smaller diameters. This was largely independent of visual field depth and varied among patients. Conclusions Because dilation/constriction is normal, VD in POAG can be explained by chronic vasoconstriction which limits energy supply to retinal (and brain) neurons with subsequent hypo-metabolism (“silent” neurons) or neuronal cell death. We propose that the root cause of POAG is primarily of vascular and not neuronal origin. This understanding can help to better personalize POAG therapy of not only targeting eye pressure but also vasoconstriction to prevent low vision, slowing its progression and supporting recovery and restoration. Trial registration ClinicalTrials.gov, # NCT04037384 on July 3, 2019.

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ABCB1 variants confer susceptibility to primary open-angle glaucoma and predict individual differences to latanoprost treatment

Hai

Yang

et al. 2016

Biomedicine & Pharmacotherapy

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Influence of Latanoprost on Retinal Microcirculation in Glaucoma

Cited by 5 publications

References 33 publications

Review of the association between retinal microvascular characteristics and eye disease

Review of the association between retinal microvascular characteristics and eye disease

Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects

ABCB1 variants confer susceptibility to primary open-angle glaucoma and predict individual differences to latanoprost treatment

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