Influence of Local Temperature Changes in the Preoptic Area and Rostral Hypothalamus on the Regulation of Food and Water Intake

Andersson, B.; Larsson, B.

doi:10.1111/j.1748-1716.1961.tb02203.x

Cited by 171 publications

(44 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Shivering, long known to be suppressed during localized warming of the pre-optic anterior hypothalamic region (Hemingway et al, 1940;Magoun et al, 1938), has recently been evoked by cooling the same region with little or no fall in skin temperature (Andersson and Larsson, 1961;Chatonnet, 1961;Hammel et al, 1960). This suggests but, in the absence of sufficient microelectrode experimentation, not altogether proves that brain temperature is "sensed" in this discrete prosencephalic region and that shivering can be evoked by its thermal activation without the support of a peripheral input from cudtaneous "cold" fibers.…”

Section: Hypothalamic Activation Of Shiveringmentioning

confidence: 99%

Effects of septal and hypothalamic lesions on shivering☆

Stuart

Kawamura

Hemingway

et al. 1962

Experimental Neurology

View full text Add to dashboard Cite

Section: Hypothalamic Activation Of Shiveringmentioning

confidence: 99%

Effects of septal and hypothalamic lesions on shivering☆

Stuart

Kawamura

Hemingway

et al. 1962

Experimental Neurology

View full text Add to dashboard Cite

“…Peripheral input, (e.g., stomach distension, Kahn, 1951;taste and smell, Teitelbaum, 1955;environmental temperature, Brobeck, 1960) central input, (e.g., level of blood glucose, ~yer, 1953; brain temperature, Andersson & Larsson, 1961; obscure hormonal factors, Davi~ Gallagher & Ladove, 1967) and psychological variables (e.g., previous experience, Baker, 1955) are aIl determinants of food intake. There is, however, little agreement on the relative ~portance of each of these factors (for recent reviews of these questions see Grossman, 1967 andHamilton, 1965).…”

Section: Introductionmentioning

confidence: 99%

Effect of hippocampal stimulation on feeding in the rat

Milgram¹

1969

Physiology & Behavior

View full text Add to dashboard Cite

“…There are, however, suggestions in the literature that hypothermia and drinking are functionally closely related. Local warming of the preoptic area induces drinking in the goat [3]. Injections of hypertonic saline solutions induce drinking as well as hypothermia in the rat [28] while deprivation alone also induces hypothermia [7].…”

Section: Influence Of Intracerebral Implantation Of Atropine Sulphatementioning

confidence: 99%

Intracerebral implantation of carbachol in the rat: Its effect on water intake and body temperature

Hulst

1972

Physiology & Behavior

View full text Add to dashboard Cite

HULST, S. G. Th. lntracerebral implantation of carbachol in the rat: its effect on water intake and body temperature.PHYSIOL. BErL~V. 8 (5) [865][866][867][868][869][870][871][872] 1972.--Intracerebral carbachol produces a fall in body temperature as well as drinking in the rat when implanted in various subcortical structures, related to the emotion-motivation limbic circuit. These effects are due to a central cholinergic stimulation since they can be prevented by the systemic administration of the centrally active anticholinergic substance atropine sulphate and to a lesser degree by methylatropine nitrate. By withholding water during the first hr following carbachol implantation it could be shown that the hypothermic response is independent from water intake. When carbachol as well as atropine sulphate are implanted in two locafisations, which both induce hypothermia as well as drinking following carbachol stimulation, atropine sulphate nearly always blocked drinking, but practically only when atropine sulphate was applied caudally to carbachol did it block hypothermia. The results suggest a drinking and hypothermic circuit within the limbic system, anatomically linked but functionally different and independent. Water intakeBody temperature Carbachol Atropine Intracerebral implantation INTRACEREBRALLY implanted carbachol elicits vigorous drinking in the water satiated rat [16,17]. Grossman [16] and Fisher and Coury [13] found that cholinergic stimulation within perifornical region, as well as the limbic system, the hypothalamus and the midbraln induced drinking. It was postulated that the emotion-motivation limbic circuit, as proposed by Papez [29,30] is intimately involved in the mediation of drinking. Further evidence for such a circuit has been presented [12,26,27,32,33]. In the rat hypothermia has been found following cholinergic stimulation of the anterior hypothalamus, lateral hypothalamus, preoptic region, nucleus lateralis septi and the area between the thalamie nuclei and the nucleus ruber [20,22,23,25]. In a previous study [20] it was suggested that cholinergically evoked drinking and hypothermia follow roughly parallel pathways in the limbic system and the diencephalon. As the fibre systems for these two phenomena need not necessarily be the same, further experiments were conducted to evaluate the previous results; these studies are reported here. MATER/AI~ AND METHODSMale white rats of an inbred Wistar strain weighing 180-190 g were used. Crystalline substances were implanted into various subcortical structures as follows. A stainless steel plate, equipped with 12 holes, was used. Tubes, with a diameter of 0.8 ram, of the same material, protruding 2.50 mm from the lower side of the plate, were attached to the holes in the plate. This plate was fixed to the rat skull with dental cement (for details see [20]). Through the tubes needles of different length, containing crystalline substances at the tip, could be directed into the brain. The operated animals were allowed to recover from the operation and...

show abstract

Influence of Local Temperature Changes in the Preoptic Area and Rostral Hypothalamus on the Regulation of Food and Water Intake

Cited by 171 publications

References 16 publications

Effects of septal and hypothalamic lesions on shivering☆

Effects of septal and hypothalamic lesions on shivering☆

Effect of hippocampal stimulation on feeding in the rat

Intracerebral implantation of carbachol in the rat: Its effect on water intake and body temperature

Contact Info

Product

Resources

About