Influence of nanoparticle mechanical property on protein corona formation

Tengjisi,; Hui, Y. H.; Fan, Yu; Zou, Da; Talbo, Gert; Yang, Guangze; Zhao, Chunxia

doi:10.1016/j.jcis.2021.08.148

Cited by 30 publications

(23 citation statements)

References 34 publications

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“…To date, nanoparticle physiochemical parameters are known to crucially affect protein corona include size 2 , 37 – 39 , shape 37 , 40 , and surface chemistry 21 , 25 , 28 , 39 (including surface hydrophobicity 21 , charge 39 , density of surface-conjugated PEG 25 ). Nevertheless, no report to our best knowledge has systematically examined the effects of nanoparticle elasticity on protein corona, despite that nanoparticle elasticity is crucial in nanoparticle’s physiological fate (both in vitro 8 , 9 , 11 – 13 and in vivo 8 , 14 – 19 ) and that protein corona formation on nanoparticles of differing elasticity may lead to different changes in nanoparticle size —protein corona formation on hard nanoparticles is manifested as an increase in particle mean diameter 20 , 22 , 33 , 41 whereas that on liposomes (known to be elastic and soft) can lead to either an increase 26 or reduction 24 , 26 in liposome mean diameter—and can result in different surface coverages of some protein family groups 42 .…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation

Jin

Liu

et al. 2022

Nat Commun

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Nanoparticle elasticity is crucial in nanoparticles’ physiological fate, but how this occurs is largely unknown. Using core-shell nanoparticles with a same PEGylated lipid bilayer shell yet cores differing in elasticity (45 kPa – 760 MPa) as models, we isolate the effects of nanoparticle elasticity from those of other physiochemical parameters and, using mouse models, observe a non-monotonic relationship of systemic circulation lifetime versus nanoparticle elasticity. Incubating our nanoparticles in mouse plasma provides protein coronas varying non-monotonically in composition depending on nanoparticle elasticity. Particularly, apolipoprotein A-I (ApoA1) is the only protein whose relative abundance in corona strongly correlates with our nanoparticles’ blood clearance lifetime. Notably, similar results are observed when above nanoparticles’ PEGylated lipid bilayer shell is changed to be non-PEGylated. This work unveils the mechanisms by which nanoparticle elasticity affects nanoparticles’ physiological fate and suggests nanoparticle elasticity as a readily tunable parameter in future rational exploiting of protein corona.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation

Jin

Liu

et al. 2022

Nat Commun

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“…[ 86b,c ] A bimodular catalytic peptide, SurSi (Table 1, Figure a), consists of a Sur module originating from AM1 to stabilize oil–water interfaces, and a Si module (RKKRKKRKKRKKGGGY) contributing to the catalytic synthesis of a silica shell thus forming an oil‐core silica–shell nanocapsule. [ 18,88 ] In addition, to further reduce the production cost of AM1, a four‐helix bundle protein DAMP4 (Table 1, Figure 6b) was designed that can be produced on a large scale in Escherichia coli . [ 19 ] It has a similar surface activity to AM1 as well as the pH‐responsive property.…”

Section: Ph‐responsive Biomoleculesmentioning

confidence: 99%

Design of Stimuli‐Responsive Peptides and Proteins

Yang

Gerstweiler

et al. 2022

Adv Funct Materials

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Stimuli‐responsive peptides and proteins are an exciting class of smart biomaterials for various applications and have received significant attention over the past decades. A wide variety of stimuli such as temperature, pH, ions, enzymes, magnetic field, redox, etc., are explored. This article provides a review of five intensively studied types of stimuli‐responsive peptides and proteins, their design principles and applications, including temperature‐, pH‐, light‐, metal ion‐, and enzyme‐responsive with an emphasis on the key design concepts and switch function. Moreover, typical examples of their applications are discussed to provide a better understanding of the design concept and underlying methodology. This review will facilitate and inspire future innovation toward new peptide‐ and protein‐based materials and their diverse applications.

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“…Inorganic silica nanocapsules with a hollow structure have been used as nanocarriers for drug delivery because of their high capacity for drug loading. Furthermore, the organic groups (e.g., vinyl, thioether, benzene, ethane, and methyl) of silica precursors reduced the numbers of siloxane bonds and further decreased the stiffness of silica nanocapsules. ,, Liposomes composed of lipids have a hydrophilic core and a hydrophobic shell similar to cell membrane structures, which have been widely used as carriers for drug delivery because of their ease of preparation, good biocompatibility, and the capacity for hydrophilic and hydrophobic drug loading. The component of the lipids can influence their phase state, which in turn affects the bending properties of the shell and the stiffness of the liposomes.…”

Section: Strategies For the Modulation Of Cp Stiffnessmentioning

confidence: 99%

“… E Y of different CPs. Reproduced with permission from (a) ref , copyright 2014 Wiley-VCH; (b) ref , copyright 2017 Elsevier; (c) ref , copyright 2018 Springer Nature; (d) ref , copyright 2020 Elsevier; (e) ref , copyright 2018 American Chemical Society; (f) ref , copyright 2022 Elsevier; (g) ref , copyright 2015 American Chemical Society; (h) ref , copyright 2022 Elsevier; (i) ref , copyright 2019 American Chemical Society; (j) ref , copyright 2019 American Chemical Society; (k) ref , copyright 2021 Wiley-VCH; and (l) ref , copyright 2015 Wiley-VCH.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Colloidal Particle Stiffness for the Exploration of Bio–Nano Interactions

Gao

Cui

2022

Langmuir

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Tuning the physicochemical parameters (e.g., size, shape, and surface chemistry) of colloidal particles (CPs) for the engineering of drug carriers has proven to be a promising approach to improve drug delivery efficacy. Recently, the stiffness of CPs has attracted widespread attention for modulating bio−nano interactions. In this perspective, we outline the strategies for the modulation and characterization of CP stiffness and highlight the importance of CP stiffness in the control over biological interactions. Challenges and opportunities of current and future developments in the modulation of CP stiffness for the exploration of bio−nano interactions in therapeutic delivery are also discussed. This perspective is expected to help thoroughly understand the role of CP stiffness in bio−nano interactions and facilitate the design of CPs as carriers for improved drug and vaccine delivery.

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Influence of nanoparticle mechanical property on protein corona formation

Cited by 30 publications

References 34 publications

Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation

Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation

Design of Stimuli‐Responsive Peptides and Proteins

Modulation of Colloidal Particle Stiffness for the Exploration of Bio–Nano Interactions

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