Influence of Neoadjuvant Chemotherapy Courses on HPV Eradication Under Non-Resectable Cervical Carcinoma

Abstract

In the article the contents of different oncogenous strains of human papillomavirus (HPV) have been studied: in 50 patients with non-resectable cervical carcinoma, 26 patients before chemotherapy: systematic (cisplatin and gemcitabin) and local with injection of gemcitabin into uterine arteries. It has been established, that among non-resectable cervical carcinomas HPV-16 is the most prevalent type, whereas the other types are scarcely diagnosed. The application of 2 chemotherapy courses, even if one of them is local with the injection of cytostatic into uterine arteries, does not lead to the eradication of HPV oncogenous strains in the patients with non-resectable cervical carcinoma.