One goal of the experiment presented here was to check, in children, the relationship between eye preference when sighting at different angles and eye dominance in binocular rivalry. In addition, since it is sometimes argued that a crossed pattern of eye-hand preference might put children at risk of difficulties in learning to read, we evaluated the relationship between this pattern and reading achievement in first and sixth graders. Results showed that a majority of children are right-eyed for monosighting, and that intrinsic preference and spatial factor influence the choice of eye. As many children were right- or left-eye dominant, and eye dominance was not related to eye preference. We found no relationship between eye-hand preference and reading proficiency, thus not confirming that a crossed pattern of eye-hand preference might put children at risk of difficulties in learning to read. Consistent handers were more advanced in reading than inconsistent handers.