Influence of oestrogen deficiency and excessive mechanical stress on condylar head of mandible

Nogami, Shinnosuke; Yamauchi, Kensuke; Odashima, Kenji; Ito, Katsuhiko; Iikubo, Masahiro; Kumasaka, Akira; Cruz, Gerardo Martinez-de la; Gaggl, Alexander; Kumamoto, Hiroyuki; Takahashi, Tsuneo

doi:10.1111/odi.13452

Cited by 5 publications

(7 citation statements)

References 27 publications

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“…Additionally, the relationship between estrogen and condylar resorption was examined using a rabbit model following an ovariectomy, which indicated that condylar head resorption in the ovariectomy group developed earlier than that in the non-ovariectomy group. Thus, it was concluded that there may be a relationship between estrogen and aggressive condylar resorption (13). Those results identified excessive mechanical stress and estrogen as risk factors for ICR.…”

Section: Discussionmentioning

confidence: 93%

“…The mandible was exposed with a submandibular approach, then an osteotomy was performed at the midline and the left side of the mandible was moved 3.5 mm forward, then ligated with a 0.4-mm wire and fixed (Figure 1a and b). The amount of forward movement used was based on previous reports presented by the authors (6,13). Fifteen rabbits were randomly divided into three groups and euthanized with an overdose of pentobarbital at one, two, and three weeks after surgery (Figure 1c).…”

Section: Methodsmentioning

confidence: 99%

“…The area and depth of resorption on the anterior surface of the condylar head were evaluated using a scoring method presented in our previous studies (6,13). Briefly, micro-CT (Comscantechno, Co., Ltd., Yokohama, Japan) examinations (65 μA and 80 kV) were performed to determine the area and depth of condylar head resorption immediately after euthanasia using samples from the mandible ramus placed parallel to the floor under standard imaging conditions.…”

Section: Resorption Area and Depth Shown By Micro-computed Tomography...mentioning

confidence: 99%

“…Histopathological analysis. Hematoxylin and eosin (HE) staining was performed using the protocol noted in our previous studies (6,13). Briefly, unilateral specimens were sliced in a sagittal direction with a thickness of 5 μm, then stained using HE.…”

Section: Resorption Area and Depth Shown By Micro-computed Tomography...mentioning

confidence: 99%

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Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases

Nogami

KATAOKA

Yamauchi

et al. 2022

In Vivo

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Background/Aim: Idiopathic condylar resorption (ICR) is a morphological change of the condylar head that occurs following orthodontic treatment or orthognathic surgery. This complication is serious, as it can cause relapse after mandible treatment. The aim of this experimental study was to evaluate the mechanism of influence of condylar resorption on compressive mechanical stress in temporomandibular joint following a change in occlusal position by mandible advancement. Materials and Methods: An osteotomy procedure at the midline of mandible was performed in 15 rabbits, with the left side moved forward by 3.5 mm. Advancement of the left side of the mandible resulted in compressive mechanical stress on condylar head on the left side. Samples were subjected to micro-computed tomography, histological staining and immunohistochemistry. Results: The area and depth of anterior condylar resorption at two weeks were significantly different as compared to those at one week (p<0.05). TRAP staining confirmed the significantly largest number of TRAP-positive cells after two weeks (p=0.02), compared to one week.

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Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Resorption Area and Depth Shown By Micro-computed Tomography...mentioning

confidence: 99%

Section: Resorption Area and Depth Shown By Micro-computed Tomography...mentioning

confidence: 99%

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Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases

Nogami

KATAOKA

Yamauchi

et al. 2022

In Vivo

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“…Oestrogen can regulate the secretion of cytokines and affect some key metabolic pathways to regulate bone and cartilage metabolism ( Wang Q. P. et al, 2012 ). Several animal studies have confirmed that oestrogen deficiency leads to cartilage degeneration in the condyle, and results in more severe TMJOA-like lesions in the presence of mechanical stress stimulation ( Nogami et al, 2020 ; Zhang J. et al, 2021 ). More studies are needed to further explore the role of oestrogen in the pathogenesis of TMJOA and related molecular mechanisms.…”

Section: Discussionmentioning

confidence: 97%

Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

Zhao

Zhou

et al. 2022

Front. Physiol.

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Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective tools for early diagnosis and disease-modifying therapies has been hindered. Animal models play a key role in understanding the pathological process of diseases and evaluating new therapeutic interventions. Although some similarities in disease processes between animals and humans are known, no one animal model is sufficient for studying all characteristics of TMJOA, as each model has different translatability to human clinical conditions. For the past 4 decades, TMJOA animal models have been studied by numerous researchers and can be broadly divided into induced, naturally occurring, and genetically modified models. The induced models can be divided into invasive models (intra-articular injection and surgical induction) or non-invasive models (mechanical loading, high-fat diet, and sleep deprivation). Different types of animal models simulate different pathological expressions of TMJOA and have their unique characteristics. Currently, mice, rats, and rabbits are commonly used in the study of TMJOA. This review sought to provide a general description of current experimental models of TMJOA and assist researchers in selecting the most appropriate models for different kinds of research.

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Idiopathic condylar resorption in adolescents: A scoping review

Nobrega,

Almeida,

Friesen

et al. 2024

J of Oral Rehabilitation

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ObjectiveIdiopathic condylar resorption (ICR), also known as progressive condylar resorption, is poorly understood, particularly in adolescent patients. Therefore, this scoping review aims to summarize the available literature on the prevalence, aetiology, pathogenesis, diagnostic process, treatment and/or any outcome regarding ICR in adolescent individuals.MethodsThis scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and its extension for scoping reviews (PRISMA‐ScR), as well as Joanna Briggs Institute studies. The search strategy was defined adopting a core search structure for each source, and the search was performed on MEDLINE, EMBASE, Cochrane Library, Web of Science, Scopus and Google Scholar. After duplicate removal, two independent reviewers screened abstracts, followed by complete articles, to achieve the definition of included studies. Data collection was performed, and the extracted data were organized in tabular form, along with a narrative summary of main findings that aligns with the objective of this review.ResultsSix observational studies were included in this review. Three studies focused on signs and symptoms, one on prevalence and signs and symptoms, one on treatment and one on disease pathogenesis.ConclusionThis scoping review revealed inadequate published research regarding prevalence, aetiology, early diagnosis, pathogenesis and treatment of ICR in adolescents.

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Influence of oestrogen deficiency and excessive mechanical stress on condylar head of mandible

Cited by 5 publications

References 27 publications

Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases

Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases

Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

Idiopathic condylar resorption in adolescents: A scoping review

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